Product Name	Clotrimazole Powder
Purity	99%
Other Names	(2-Chlorophenyl)diphenyl-1-imidazolylmethane
CAS No.	23593-75-1
M.F.	C22H17ClN2
MW	344.84
Appearance	White Powder
Density	1.43
Storage Temperature	−20°C
Solubility	H2O: 5 mg/mL,soluble
Usage	Pharmaceuticals
Storage	Keep in cool & dry place, stay away from strong light and heat
Shelf Life	24 months

Products Description

What is Clotrimazole Powder 99%?

Clotrimazole is a synthetic antifungal agent belonging to the imidazole class. that has inhibitory effects on various pathogenic fungi. At high concentrations, it can also have bactericidal effects. Clotrimazole inhibits the biosynthesis of sterols such as ergosterol in fungi by interfering with the activity of cytochrome P450. lt damages the fungal cell membrane and alters its permeability, resulting in the loss of important substances within the cells; It can also inhibit the biosynthesis of triglycerides and phospholipids in fungi; This product can also inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxides within cells, leading to degeneration and necrosis of the subcellular structure of fungi. Clotrimazole has broad-spectrum antifungal activity and has good antibacterial effects on Dermatophytes epidermidis, Trichophyton mentagrophytes, Aspergillus, chromogenic fungi, Cryptococcus and Candida. It also has certain antibacterial activity against Sporococcus Schenckii, Bacillus dermatitis, Trichophyton and Histoplasma.

Clotrimazole Powder 99% is a broad-spectrum antifungal agent, which has a good antibacterial effect on a variety of fungi, especially candida albicans. Its mechanism of action is to inhibit the synthesis of fungal cell membrane and influence its metabolic process.It has antibacterial effect on both superficial fungi and some deep fungi.Clinical mainly for external use, treatment of dermatomycosis, such as tinea pedis, tinea body, ear canal, vaginal mycosis, etc.This product is relatively toxic when taken orally, oral can have gastrointestinal reaction, liver function abnormality and leukopenia, etc.It is now used sparingly.External use no adverse reactions, Occasional local inflammation may occur.1% ~ 3% cream and suppository for external use.

Product COA

Certificate Of Analysis

Sample	Clotrimazole	Batch No.	20240408
Quantity	500KG	Manufacturing Date	2024.04.14
Cas Number	23593-75-1	Expiry Date	2027.04.13
Items	Standard		Results
Characteristic	White to pale yellow,crystalline powder		Conforms
Solubility	Practically insoluble in water,freely soluble in methanol,in acetone,in chloroform. and in alcohol		Conforms
Identifieation	Infrared Absorption thin-layer chromatography identification		Conforms
Related Compound A	≤0.5%		Conforms
Melting Point	141-145℃		143.4-144.5℃
Iminazole	≤0.5%		Conforms
Loss on Drying	≤0.5%		0.32%
Residue on ignition	≤0.1%		0.01%
Heavy Metals	≤0.001%		Conforms
Total Plate Count	＜1000cfu/g		Conforms
Total Yeast and Mould	＜100cfu/g		Conforms
E.Coli	Negative		Conforms
Assay	98%-102%		99.2%
Conclusion	Conform to USP39,EP6.0

Mechanism of Action Clotrimazole 99%

Antifungal skin drugs used to treat deep and superficial fungal diseases caused by sensitive bacteria. Such as cryptococcal meningitis, candida pneumonia, enteritis, histoplasmosis, ringworm of the body, ringworm of the hand and foot, etc. Among them, the treatment of candidiasis has the best effect, while the treatment of tinea capitis has no effect either for external or internal administration.

1. Antibacterial Spectrum: Effective against Candida albicans, Candida glabrata, dermatophyton (such as trichophyton), but poor effect on aspergillus, cryptococcus.Candida albicans can inhibit the process of its transformation from spores to invasive mycelium.

2.Drug Resistance: Long-term use may lead to drug resistance, and abuse should be avoided.By reducing the activity of cytochrome P450, it inhibits the biosynthesis of sterols such as ergosterol in the fungal cell membrane, damages the fungal cell membrane and alters its permeability, causing the loss of important intracellular substances.

3. Clotrimazole can also inhibit the biosynthesis of triacylglycerol and phospholipids in fungi.
4. It can also inhibit the activity of oxidase and peroxidase, leading to excessive accumulation of hydrogen peroxide within cells, causing degeneration of the subcellular structure of fungi and cell necrosis.

Main Application Field of Clotrimazole 99% Powder

1.Cutaneous fungal infection
Ringworm of the body, jock itch, tinea of the hands and feet: topical cream or solution 2-3 times a day for 2-4 weeks.
Tinea versicolor (sweat spots) : Apply locally, with anti-fungal lotion for better effect.
Skin candidiasis: such as interrub rash, diaper rash, etc., need to keep the affected area dry after medication.

2. Vaginal Candida Albicans Infection
Vaginal suppositories/ointments: The usual dosage is once per night (100mg or 500mg) for 1-7 days (depending on the dosage form).
Recurrent Infections can be treated in combination with oral fluconazole.

3. Oral and digestive candidiasis
Oral lozenges: Slowly dissolve 3 to 4 times a day for 7 to 14 days.
For oral or esophageal candida infections in immunosuppressed patients (e.g., HIV/AIDS, post-chemotherapy).

4. Other fungal infections
Fungal infection of ear canal: Apply ear drops topically, 2-3 times daily.
Onychomycosis (gray nails) : long-term topical use (with urea ointment to remove nails), but the effect is weaker than oral drugs.

Why Chosse us?

FAQ

Q: 1. I want to know more details about the product, how can I contact you?

A: You can send us an email inquiry at any time. For more accurate quotes, I need the following information: product name, order quantity, receipt country, quality requirements, etc.

Q: 2. How do I know if your products are real or fake?

A: We will inspect every shipment. I can provide test reports including HPLC, MS and HNMR if you want. Please find a professional chemist to help you confirm the authenticity of the test report.
Of course, you can also purchase samples to take you around your trust.

Q: 3. How do you ensure the safety of the package I receive?

A: I want to receive the package safely, I first need to know your delivery address, do you have a preferred courier method, did you buy it from China?
Why do you want to know?
Because each country has different requirements for imported packages, especially chemical products, you need to know the basic information to provide you with the safest choice.
At present, we have professional customs clearance agents in EU countries, the United States, the United States, Canada, and Southeast Asia. We have professional customs clearance agents to ensure the safety of packages.

Q: 4. How to pay?

A: Our payment channels include bittoin, bank card, Western Union, Allegitudes, etc.
It is usually recommended that customers pay with Bitcoin, because the fee is low, the entry speed is fast, and the security is guaranteed.

Q: 5. How long does it take to receive the package?

A: This will vary according to the delivery method you choose. I will briefly introduce our commonly used special lines.
Usually European countries 10-15 days after sending you the tracking number.
In the United States and Canada, it usually takes 7-10 days.
Southeast Asian countries are 3-7 days.

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