Loratadine Powder

Loratadine is a second-generation antihistamine widely used to relieve allergy symptoms such as allergic rhinitis (seasonal or perennial), urticaria, etc. By selectively blocking histamine H1 receptors, it reduces symptoms such as sneezing, nasal itching, runny nose, eye itching and skin itching caused by allergic reactions, and because it is not easy to penetrate the blood-brain barrier, drowsiness side effects are significantly reduced compared with first-generation antihistamines (such as pramine).

Regularly packed in aluminum foil bags, and you can customize the packaging bags according to your requirements 

Loratadin is USP grade and can be used for health care products and can be used in different shapes of tablets according to your requirements.

 

Loratadin is fine powder, no caking, latest batch

 

The solubility of the product in different solvents select suitable solvents to prepare the reserve solution; Once the solution is prepared, please store it separately to avoid product failure caused by repeated freezing and thawing. Storage method and duration of the reserve liquid: -80°C, 2 years; -20°C, 1 year.

For storage at -80°C, use within 2 years, for storage at -20°C, use within 1 year

The main application of loratadine is concentrated in the pharmaceutical field,as an anti-allergy drug.

1.Loratadine is a second-generation antihistamine that inhibits symptoms caused by allergic reactions by selectively blocking histamine H1 receptors, and is mainly used in the following diseases
1).Relieve seasonal rhinitis such as nasal congestion, runny nose, sneezing, nasal itching and eye itching, and control persistent nasal inflammation such as dust mites and pet dander allergies
2).Urticaria: Relieve acute or chronic urticaria skin itching, redness, wind.

2.Drug dosage forms and usage
Loratadine is mainly used clinically in the following dosage forms: oral tablets/capsules, oral solutions/syrups, dispersible tablets. The dosage requirements for each form are different, and the intake is accurate according to body weight.

Xi'an Tongze Biotechnology can provide raw materials, product stability, the latest production batches, and can support customized tablets/capsules.

1.Antihistamine action

Selectively antagonize the peripheral H1 receptor, reduce histamine binding to the receptor, inhibit histamine-induced vasodilation, increased permeability and nerve end stimulation, thereby relieving allergic symptoms.

2.Adjuvant anti-inflammatory effect

Inhibit the chemotaxis and activation of inflammatory cells (such as eosinophils) and reduce the inflammatory response of chronic allergies.

3.Security advantage

It is not easy to penetrate the blood-brain barrier, has little impact on the central nervous system, and has a low risk of sleepiness, which is suitable for people who need to focus (such as drivers and students)

The effect of a single administration can last for 24 hours, reflecting its long-term performance and high compliance

4.The combination of drugs is more effective

In the case of severe allergy, combined with nasal glucocorticoids (such as mometasone furoate), enhance the anti-inflammatory effect.

In the case of chronic urticaria, it may be combined with leukotriene receptor antagonists (such as Montelukast) or omalizumab (biologics)

Although loratadine is primarily used for allergies, subtle considerations apply in different scenarios, allowing selection based on specific symptoms and needs. Details are as follows:
1) For common allergic rhinitis and chronic urticaria: Any standard 10mg dosage form (tablets, capsules, dispersible tablets) is suitable.
2) For acute symptoms requiring rapid relief: Dispersible tablets may act slightly faster due to their quicker dissolution rate.
3) For individuals requiring high alertness during daytime (e.g., drivers, workers at heights): Loratadine is a non-sedating antihistamine, though very few may experience mild drowsiness. If you are particularly concerned, consider taking it before bedtime or consult your doctor about alternative options.
4) For patients with severe nasal congestion: Compound formulations like "Loratadine Pseudoephedrine Tablets" are available, combining allergy relief with congestion-reducing ingredients. However, pseudoephedrine carries potential side effects (e.g., elevated blood pressure, insomnia) and should be used under pharmacist or physician guidance. Individuals with hypertension or heart conditions should exercise caution.

For loratadine, the product is Active Pharmaceutical Ingredient, our production workshop meets the requirements of GMP certification, and we have a GMP certificate

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