Estradiol Powder

                                                         99% Pure Low Price Estradiol Powder CAS 50-28-2 Estradiol

Estradiol is a white or milky white ordorless crystalline powder. It is slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.

Estradiol, estra-1,3,5(10)-triene-3,17β-diol, is the most activeof the natural steroid estrogens. Although its 17β-OHgroup is vulnerable to bacterial and enzymatic oxidation toestrone, it can be temporarily protected as anester at C3 or C17, or permanently protected by adding a17α-alkyl group (e.g., 17α-ethinyl estradiol, the most commonlyused estrogen in oral contraceptives). The increasedoil solubility of the 17β-esters (relative to estradiol) permitsthe esters to remain in oil at the IM injection site for extendedperiods. These derivatives illustrate the principles of steroidmodification. Transdermal estradiolproducts avoid first-pass metabolism, allowing estradiol tobe as effective as oral estrogens for treating menopausalsymptoms. A new transdermal spray, Evamist, was approvedin 2007. Estradiol itself is typically not very effective orallybecause of rapid metabolism, but an oral formulation of micronizedestradiol that allows more rapid absorption of thedrug is available (Estrace). In addition to the oral and transdermalproducts, estradiol is also available in gel, cream, andvaginal ring formulations.

1.Estradiol (E2 or 17β -estradiol) (also oestradiol) is a sex hormone.
2.Estradiol is the predominant sex hormone present in females. It is also present in males,And at a higher level because it is being constantly produced.In females it is only produced 3 out of 30 days of the cycle. It represents the major estrogen in humans.
3.Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including the bones.Estrogens direct the development of the female genotype in embryogenesis and at puberty.
4.Estradiol is the major estrogen secreted by the premenopausal ovary.Estradiol benzoate is an estradiol analog
which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to
induce estrus in domestic livestock. This compound binds to the human and murine estrogen receptor
α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction
in binding affinity compared to estradiol.

1. Applied in pharmaceutical field, Estradiol is used as Endocrine System Agents;

2. Applied in Chemicial field, Estradiol can be used as Auxiliaries and Other Medicine Chemicals

Reproductive system: Breast tenderness, nipple discharge, menstrual irregularities (spotting, amenorrhea)

Gastrointestinal: Nausea, bloating, abdominal cramps

Dermatological: Skin rash, itching, increased pigmentation (especially on face with sun exposure)

Neurological: Headaches, dizziness, mood swings, insomnia

🚨 Serious Adverse Reactions (Seek Immediate Medical Help)

Cardiovascular risks: Chest pain, shortness of breath, sudden severe headache (possible blood clot or stroke)

Malignancy concerns: Unusual vaginal bleeding, breast lumps, persistent pelvic pain (risk of endometrial/breast cancer)

Allergic reactions: Swelling of face/lips/tongue, difficulty breathing, hives

Contraindications: History of hormone-sensitive cancers (breast/uterine), active thromboembolism, liver disease

Monitoring requirements: Regular mammograms, Pap smears, liver function tests

Drug interactions: Avoid with blood thinners, anticonvulsants, and herbal supplements like St. John's Wort

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Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

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