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Product Name |
Hydroxychloroquine Powder CAS 118-42-3 Hydroxychloroquine |
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Appearance |
White powder |
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CAS |
118-42-3 |
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Molecular formula |
C18H26ClN3O |
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Molecular Weight |
335.88 |
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Keywords |
Purity Hydroxychloroquine;Hydroxychloroquine Powder;Raw Powder Hydroxychloroquine |
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Shelf Life |
24 months when properly stored |
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Storage |
Keep in a cool, dry, dark location |
Products Description
What is hydroxychloroquine ?
Hydroxychloroquine sulfate is an antimalarial drug, which also has anti-inflammatory, immunomodulatory and anticoagulant effects. At present, hydroxychloroquine is mainly used in the clinical treatment of rheumatoid arthritis, juvenile chronic arthritis, discoid lupus erythematosus and systemic erythema Lupus, but the clinical onset is slow, and it usually takes 2 to 4 months.
COA
Certificate Of Analysis
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Product Name |
Hydroxychloroquine Sulfate |
Batch No. |
HZP20241102 |
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Quantity |
401.5KG |
Man. Date |
2024-11-03 |
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Packaging |
25KG/Drum |
Test Date |
2024-11-04 |
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Expiry Date |
2027-11-04 |
Report Date |
2024-11-04 |
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Test Items |
Standard |
Test Results |
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Characteristics |
White or practically white crystalline powder, Is odorless and has a bitter taste |
Complies |
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Identification |
Complies |
Complies |
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Solubility |
Freely soluble in water,practically insoluble in alcohol,in chloroform,and in ether |
Complies |
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Melting point |
238~242℃ |
241.5℃ |
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PH |
3.5~5.5 |
4.2 |
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Loss on drying |
≤2.0% |
0.3% |
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Related substances |
Total impuritites≤2.0% |
Complies |
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Residual solvent |
Ethanol ≤5000ppm Ethyl acetate≤5000ppm Dichloromethane≤600ppm Isopropanol ≤5000ppm |
2733ppm 32ppm ND ND |
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Assay |
98.0%~102.0% |
101.0% |
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Conclusion |
Complies with USP41 standards. |
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Function of hydroxychloroquine
Antimalarial Effect
Inhibit the metabolism of Plasmodium
Concentrated in the lysosomes of the malaria parasite, it raises the pH value, blocks the activity of heme polymerase → accumulation of toxic heme → death of the parasite.
Effective only for sensitive strains:
It is effective against chloroquine-sensitive Plasmodium (such as vivax malaria and terarium malaria), but ineffective against drug-resistant malaria.
Immune Regulation (Core Value)
Inhibit Toll-like receptor (TLR) signaling
Block TLR7/9 activation and reduce the release of inflammatory factors such as IFN-α and TNF-α (Nature Immunol, 2005).
Stable lysosomal membrane
Reduce the efficiency of antigen presentation and inhibit the activation of self-reactive T cells.
Interfere with calcium signals
Inhibit the expression of CD154 on T cells and block the activation of B cells.
Application of hydroxychloroquine
Hydroxychloroquine Sulfate (HCQ) is an antimalarial drug used to treat systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases, inflammation and skin diseases. It is also an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
Autoimmune Disease
Systemic lupus erythematosus (SLE) : Control skin and joint lesions and reduce disease activity (SLEDAI score).
Rheumatoid arthritis (RA) : Relieves joint swelling and pain, and delays bone destruction (combined with methotrexate).
Sjogren's syndrome: Improves symptoms of dry mouth and dry eyes.
Malaria Prevention and Treatment
Prevention: Start taking it 1-2 weeks before entering malaria-endemic areas (400mg per week for adults).
Treatment: It is necessary to combine with other antimalarial drugs (such as chloroquine phosphate), and drug resistance is prone to occur when using a single drug.
Dosage and Administration (for adults)
Take during meals: Reduces gastrointestinal irritation.
Renal/liver insufficiency: Dosage adjustment is required (contraindicated when eGFR < 30ml/min).
Pediatric medication: For malaria prevention only (6.5mg/kg per week, not exceeding 400mg).
Why choose our Hydroxychloroquine Powder?
1.AFTER SALES
Effective reshi aftersales service
2.CUSTOMIZED
Customized Labelsand packageOEM /ODM service
3.STORAGE ROOM
USA warehouse
4.PRICE
Reasonablecompetitive price
Packaging & Shipping
Packaging: 25kg/bag or according to client request
Delivery Detail: 1~2 weeks after confirm order.Some of the products can be supplied within 7 days on the strength of EDC warehouse.
FAQ
Q1: What service can you provide?
A:We can provide very competitive prices and very good service to our clients all over the world.
Q2: Can you do customized?
A:We can make the products as per customers' requested products and quantity
Q3:Can we have samples for development?
A:Yes we can provide free samples (small quantity) to you, but the freight cost on buyer's account.
Q4:What is the normal lead time?
A:1. For stock products, we will send goods to you within 2-3 days after we receive your payment.
2. For customized products, generally the delivery time is around 30 days after we receive your payment.
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