99% Pure Pregabalin Powder

Pregabalin powder is a white crystalline pharmaceutical raw material, classified as a structural derivative of gamma-aminobutyric acid (GABA). It is an orally active synthetic anticonvulsant and analgesic agent that binds selectively to the α2-δ subunit of voltage-gated calcium channels in the central nervous system, without directly activating GABA receptors.

Mechanism of Action

Pregabalin selectively attaches to α2-δ calcium channel subunits in brain and peripheral nerve tissues. It inhibits the excessive release of excitatory neurotransmitters such as glutamate, norepinephrine and substance P. This suppresses abnormal overexcitation of nerve signals, thereby relieving neuropathic pain, stabilizing overactive nerve circuits and reducing seizure susceptibility.

1. Treatment of Neuropathic Pain

Peripheral diabetic neuropathy: Relieves burning, stabbing, tingling pain in hands and feet caused by long-term diabetes.

Postherpetic neuralgia: Alleviates persistent nerve pain left after shingles rash heals.

Fibromyalgia: Reduces widespread chronic muscle and joint pain, stiffness and tenderness all over the body.

Spinal cord injury-related neuropathic pain and trigeminal neuralgia adjuvant relief.

2. Adjunct Therapy for Partial-Onset Seizures

Used as add-on treatment for adults and children aged 4 years and older with partial epilepsy. It lowers the frequency of focal seizures that start in one localized brain region when single anti-seizure medicines fail to fully control symptoms.

3. Management of Generalized Anxiety Disorder (GAD)

It calms persistent excessive worry, nervousness, restlessness, sleep disturbance and tension symptoms in patients with long-term generalized anxiety, delivering sustained anxiolytic effects.

4. Improvement of Sleep Disturbances Secondary to Nerve Pain or Anxiety

By easing nerve irritation and anxiety tension, pregabalin significantly reduces difficulty falling asleep, frequent nighttime awakenings and unrefreshing sleep caused by chronic pain or anxious mood.

Additional Clinical Features

Fast gastrointestinal absorption with high bioavailability, and food intake barely affects its absorption efficiency.

It undergoes minimal liver metabolism and is mostly excreted unchanged through urine, bringing low liver metabolic burden.

Uniform efficacy across different age groups with adjustable dosages based on renal function and symptom severity.

1. Pregnancy

Risk Profile

Pregabalin crosses the human placenta and reaches fetal circulation. There is limited sufficient large-scale clinical data to fully confirm its absolute safety for pregnant women. Animal studies show fetal developmental risks at high doses, including delayed growth and skeletal abnormalities.

Clinical Recommendations

Pregabalin should only be used in pregnancy if the clinical benefit clearly outweighs all potential fetal risks, and must be prescribed by a specialist physician.

Women of childbearing age must use reliable contraception while taking pregabalin unless they plan to become pregnant.

If pregnancy is confirmed during treatment, patients shall inform doctors immediately for risk reassessment. Do not discontinue pregabalin abruptly without medical guidance; sudden dose stop may trigger severe seizures or rebound neuropathic pain, which also endangers the fetus.

Pregnant patients receiving pregabalin require close prenatal monitoring for fetal development.

2. Breastfeeding

Drug Transfer

Pregabalin is excreted into human breast milk in measurable concentrations. Nursing infants will ingest the drug via milk. The half-life of pregabalin is long in young babies, which easily causes drug accumulation in infants' bodies.

Potential Risks to Infants

Infants exposed to pregabalin through breast milk may experience drowsiness, poor feeding, lethargy, breathing suppression, delayed motor development and weight gain retardation. Newborns and premature babies have immature renal function and are more vulnerable to adverse effects.

Clinical Advice

Breastfeeding is generally not recommended during pregabalin treatment.

If pregabalin therapy is medically necessary for the mother, doctors will advise discontinuing breastfeeding to avoid infant exposure.

If breastfeeding cannot be stopped temporarily, close observation of the baby's alertness, feeding behavior and breathing is mandatory. Any signs of excessive sedation require immediate medical consultation.

1. General Oral Administration Route

Pregabalin powder is for oral use only, it cannot be injected or applied topically.

Mix the required dose of pure pregabalin powder with clean water, fruit juice or plain food such as porridge and yogurt for ingestion.

Take the prepared mixture completely at one time to avoid incomplete dosage intake.

2. Standard Dosing Schedule (Based on Different Conditions)

(1) Neuropathic Pain (Diabetic Neuralgia, Postherpetic Neuralgia)

Initial dose: 150 mg per day, divided into two or three separate doses.

If pain relief is insufficient after 3–7 days, the daily dose can be gradually increased to a maximum of 600 mg daily as advised by a doctor.

(2) Partial Onset Seizures (Adjunct Treatment)

Starting dose: 150 mg daily split into 2–3 doses.

Titrate dose slowly based on seizure control; the maximum daily limit is 600 mg.

(3) Generalized Anxiety Disorder

Initial dosage: 150 mg per day in divided doses.

Adjust upward every week if anxiety symptoms do not improve, with a ceiling dose of 600 mg daily.

(4) Fibromyalgia

Begin with 150 mg daily, increase stepwise if widespread pain persists, maximum 450–600 mg per day.

3. Timing of Intake

Can be taken with or without meals; food does not interfere with pregabalin absorption and efficacy.

Maintain fixed intervals between doses to keep stable drug concentration in blood.

For patients with sleep troubles caused by pain or anxiety, a larger portion of the daily dose can be taken in the evening before bedtime under medical guidance.

4. Special Population Dosage Adjustment

Patients with Renal Impairment

Pregabalin is mainly eliminated through kidneys. People with poor kidney function must reduce total daily dose and extend dosing intervals to prevent drug accumulation and side effects. Regular renal function tests are required.

Elderly Patients

Older adults often have mild renal decline; start with the lowest initial dose and adjust slowly under close monitoring.

Children

Dosage is calculated strictly according to body weight for pediatric epilepsy patients, only used under pediatric physician supervision.

5. Critical Administration Precautions

Do not abruptly stop taking pregabalin powder after long-term use Sudden withdrawal may cause rebound pain, insomnia, panic attacks, sweating, nausea or increased seizure frequency. If treatment needs to end, gradually reduce the daily dose over at least one week.

Strictly follow prescribed dosage Never increase or double the dose on your own for faster symptom relief; high doses raise risks of dizziness, drowsiness and blurred vision.

Missed dose handling Take the forgotten dose as soon as you remember unless it is nearly time for the next scheduled dose. Do not take two doses at once to make up for the missed one.

Avoid hazardous activities after intake Pregabalin commonly causes dizziness and somnolence. Do not drive vehicles, operate heavy machinery or perform high-risk work after taking it.

Storage reminder Seal the pregabalin powder away from moisture and direct sunlight to avoid deterioration before mixing and taking.

1. Central Nervous System Reactions (Most Frequent)

Drowsiness, sleepiness, fatigue and lassitude

Dizziness, lightheadedness, unsteady gait and coordination disturbance

Headache, blurred vision, double vision and difficulty focusing eyes

Poor concentration, slow reaction speed, memory impairment and brain fog

Tremor, slight involuntary shaking of hands or limbs

Euphoria or mood swings in individual patients

2. Digestive System Discomfort

Dry mouth (one of the most typical mild side effects)

Nausea, vomiting, stomach bloating and flatulence

Constipation or mild diarrhea, decreased appetite

3. Weight and Edema Issues

Peripheral edema: swelling of hands, ankles and feet due to fluid retention

Unintentional weight gain with long-term administration

4. Psychiatric & Emotional Symptoms

Nervousness, restlessness

Difficulty falling asleep or abnormal sleepiness during daytime

Reduced libido, sexual dysfunction

5. Other Mild Common Reactions

Nasal congestion, dry nose

Muscle soreness, joint discomfort

Sweating abnormally

Key Supplementary Notes

Most mild side effects usually appear within the first 1–2 weeks after starting medication, and will gradually ease as the body adapts to the drug.

These adverse reactions tend to become more obvious if the dose is increased rapidly. Slow dose titration can effectively lower their occurrence rate.

Avoid driving, machine operation and other high-risk tasks when obvious dizziness or drowsiness occurs.

If edema, persistent blurred vision or severe mental discomfort lasts for a long time, consult a doctor to adjust the dosage timely.

1. Dizziness, Drowsiness and Tiredness (Most Common Side Effects)

Slow dose titration: Increase your daily dose step by step instead of jumping to a high dose at once, which gives your nervous system time to adapt.

Adjust dosing schedule: Take the majority of your daily dose before bedtime. Smaller doses taken during the day will lessen daytime sleepiness.

Avoid high-risk activities: Do not drive, operate heavy equipment or work at heights when you feel dizzy or sleepy.

Avoid alcohol, sleeping pills and antihistamines; these substances will intensify sedation and balance problems.

Sit or lie down immediately if you feel lightheaded to prevent falls.

2. Dry Mouth

Sip warm water regularly throughout the day.

Chew sugar-free gum or suck sugar-free hard candies to boost saliva production.

Cut down on coffee, strong tea, salty and spicy foods that dehydrate the mouth.

3. Peripheral Edema (Swollen hands, ankles and feet) & Weight Gain

Control salt intake: Stay away from pickles, processed meat, salty condiments and fast food to reduce fluid retention.

Elevate swollen limbs while resting; take mild walks to improve blood circulation.

Avoid tight shoes, socks or wristbands that restrict blood flow.

Notify your doctor if swelling does not fade; your doctor may lower your pregabalin dosage.

4. Gastrointestinal issues (nausea, bloating, constipation)

Mix and take pregabalin powder with food to reduce stomach irritation.

For constipation: Eat high-fiber fruits, vegetables and whole grains, and drink enough water every day.

Split your total daily dose into 2–3 smaller servings to lower stomach discomfort from a single large dose.

5. Blurred vision, poor focus and memory fog

Rest your eyes frequently and limit prolonged screen time when your vision feels fuzzy.

Avoid complicated mental tasks shortly after taking the powder.

Visit your doctor right away if blurred vision lasts or becomes worse.

6. Sleep disorders, anxiety and mood swings

Never stop pregabalin suddenly. Abrupt withdrawal triggers insomnia, panic and rebound nerve pain. Taper off the dose gradually over at least one week under medical advice.

Cut caffeine, energy drinks and strong tea after noon to stabilize night sleep.

Stick to a fixed sleep routine to ease restless feelings.

7. Hand tremors and muscle aches

Reduce caffeine intake, which can aggravate shakiness of hands.

Do gentle stretching exercises and avoid overexertion to relieve muscle soreness.

8. Severe adverse reactions (Emergency handling)

Stop using pregabalin powder and seek urgent medical care if you develop any of the following:

Severe skin rash, hives, facial/lip/throat swelling or breathing difficulty (severe allergy)

Severe confusion, hallucinations or suicidal thoughts

Extreme swelling all over the body, sharp chest pain or trouble urinating

General Preventive Guidelines

Always follow the doctor's prescribed dose; do not raise the dosage on your own for faster pain relief.

Patients with kidney disease must use a reduced dose, as pregabalin is mostly excreted by the kidneys and may build up in the body.

Keep regular check-ups to monitor weight, limb swelling, vision and mental state, and report persistent discomfort to your physician timely.

Always follow the doctor's prescribed dose; do not raise the dosage on your own for faster pain relief.

Patients with kidney disease must use a reduced dose, as pregabalin is mostly excreted by the kidneys and may build up in the body.

Keep regular check-ups to monitor weight, limb swelling, vision and mental state, and report persistent discomfort to your physician timely.

Product list

Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

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