Pure Clascoterone Powder

Clascoterone powder is a high-purity synthetic steroidal small-molecule raw material, a novel topical androgen receptor antagonist with chemical name (7α,11α,17α)-17-hydroxy-11-methyl-7-(2-propenyl)-19-norpregn-4-en-3-one. It is developed specifically for skin topical application, supplied as fine crystalline pharmaceutical powder for cosmetic and dermatological drug manufacturing. Unlike oral anti-androgens, clascoterone acts locally on skin tissue with minimal systemic absorption into blood circulation.

(1) Treat Moderate to Severe Acne Vulgaris (Primary Indication)

Suppress sebaceous gland hyperactivity: Cut excessive sebum secretion to reduce oily skin and shiny complexion.

Inhibit follicular keratinization: Prevent dead skin cells from clogging pores to avoid blackheads, whiteheads and closed comedones.

Reduce inflammatory response: Lower pro-inflammatory cytokines in blocked follicles, relieve red, swollen cystic and pustular acne, and ease acne pain.

Reduce post-acne inflammatory pigmentation by controlling persistent follicular inflammation.

(2) Improve Androgenetic Alopecia (Male & Female Pattern Hair Loss)

By blocking DHT binding to hair follicle androgen receptors:

Slow miniaturization of hair follicles triggered by high local DHT concentration.

Reduce daily abnormal hair shedding, thicken fine, thin vellus hairs into terminal hairs.

Alleviate scalp oiliness, itching and follicular inflammation associated with hormonal baldness.

(3) Relieve Hormonal Seborrheic Dermatitis

Control overactive sebaceous glands on scalp, forehead and cheek areas; ease flaking, redness and persistent itching caused by androgen-driven sebum overproduction.

(4) Reduce Hirsutism (Excess Facial/Body Hair in Females)

Topical application inhibits androgen stimulation of hair follicles on chin, upper lip and jawline, slowing growth of coarse dark unwanted facial hair in women with hormonal hirsutism.

4. Key Advantages Compared with Other Anti-Androgen Raw Materials

Minimal systemic side effects: Hardly absorbed into bloodstream, no risk of disrupting whole-body hormone balance, unlike oral spironolactone or finasteride.

Dual target for both acne and hair loss in topical formulas.

Low irritation risk, compatible with most topical skincare excipients.

Suitable for long-term daily topical use for hormonal skin disorders.

Prescription dermatological pharmaceutical raw material (acne treatment cream/gel, scalp anti-hair loss topical preparations)

High-efficiency functional cosmetic raw material for oil-control, anti-acne and anti-hair-loss serums, lotions and essences

Laboratory research reagent for androgen receptor pharmacology and dermatology studies

Core Conclusion

Clascoterone raw powder is only for compounding topical skin preparations. Routine use is not recommended for pregnant or breastfeeding women, and self-use must be avoided. Medical approval from a dermatologist and obstetrician is required if application is absolutely necessary.

1. Safety Basis for Pregnancy

Limited human clinical pregnancy data There are no large-scale, long-term controlled trials fully confirming the safety of topical clascoterone for pregnant women. Animal reproductive toxicology tests lack sufficient definitive evidence to rule out subtle risks to fetal hormone development.

Low but measurable transdermal absorption Though systemic absorption through intact skin is minimal, heavy application over wide facial/scalp areas, or use on broken, inflamed, peeling skin raises blood levels of clascoterone slightly. As an androgen receptor antagonist, trace systemic exposure may theoretically interfere with normal androgen-related developmental processes of the fetus.

Clinical official advice FDA and dermatology guidelines suggest reserving clascoterone for pregnancy only when the expected benefits clearly outweigh potential unknown fetal risks, with strict low-concentration, limited-area short-term use under doctor monitoring.

2. Safety Risks During Breastfeeding

Risk of transfer to infants via breast milk Small amounts of absorbed clascoterone can enter breast milk after repeated daily topical administration. Infants have immature hormone regulatory systems; exogenous anti-androgen compounds may disrupt their normal endocrine development.

Direct contact hazard If clascoterone cream/gel is applied on the face, neck or chest, residual product on the skin can transfer to the baby's skin or mouth during breastfeeding, triggering skin irritation or unintended local anti-androgen exposure in the infant.

Standard clinical suggestion Avoid regular use during the entire breastfeeding period. If severe hormonal acne or scalp conditions cannot be controlled by milder alternatives, discontinue breastfeeding temporarily while using clascoterone topical products.

3. Acceptable Alternatives for Pregnant & Lactating Women

For acne and oily skin issues, doctors usually prioritize safer mild topical ingredients with negligible systemic absorption:

Azelaic acid

Gentle niacinamide

Low-concentration hyaluronic acid and soothing panthenol

Mild topical antibiotics approved for pregnancy (prescription only)

4. Special Restrictions If Medical Use Is Unavoidable

If dual specialists approve limited use:

Use the lowest effective concentration (0.5% instead of 1%);

Apply only on small localized affected areas, avoid full-face or full-scalp coverage;

Reduce application frequency to once daily, preferably before bedtime;

Wash hands thoroughly after application; avoid skin-to-infant contact on treated regions;

Stop use immediately once any skin irritation occurs.

Clascoterone raw powder cannot be used directly on skin; it must be formulated into gel, cream or scalp lotion first. The onset timeline differs by treatment target: acne, oily skin, scalp seborrhea and androgenetic alopecia.

1. Improvements for Acne & Excess Facial Oil (Fastest onset)

2–4 weeks (early mild changes)

Sebum secretion drops noticeably; skin looks less shiny within hours after each application

Fewer new small pimples and whiteheads form; less pore clogging

Reduced facial greasiness throughout the day

6–8 weeks (obvious visible improvement)

Sharp decline in inflammatory red pustules and cystic acne

Less acne tenderness and facial inflammation

Fading of fresh acne red marks caused by follicular swelling

12 weeks (full therapeutic effect, clinical standard cycle)

Most clinical trials adopt a 12-week observation period. After consistent daily use:

Severe cystic acne is well-controlled

Closed comedones are significantly cleared

Long-term recurrence rate of hormonal acne is lowered

2. Oily Scalp & Seborrheic Dermatitis

1–3 weeks

Scalp itchiness, flaking and excess oil production are relieved; less greasy hair by the afternoon.

6–8 weeks

Scalp redness and recurring tiny inflamed follicle bumps basically disappear.

3. Androgenetic Alopecia (Hair Loss, Slowest effect)

Hair follicle miniaturization is a chronic progressive process, so results take far longer:

1–2 months

Scalp oiliness and daily hair shedding start to decrease; fewer hairs fall out during shampooing.

3–6 months

Key visible turning point:

Fine, thin vellus hairs become thicker and stronger

Expanding bald/thin areas slow down or stop worsening

6–12 months

Noticeable density improvement on thinning regions (hairline, crown); sustained daily scalp application is mandatory. Intermittent use will delay effects greatly.

Key Factors That Speed Up or Delay Results

Formulation concentration 1% clascoterone delivers faster results than 0.5% low-strength formulas, yet carries higher irritation risk.

Frequency of application Twice-daily use accelerates effects; once-every-other-day use extends the waiting period.

Skin barrier condition Dry, sensitive or damaged skin needs longer adaptation time, and irritation may interrupt consistent use.

Concurrent irritating actives Simultaneous use of retinol, benzoyl peroxide or high-concentration exfoliants causes peeling/stinging, which often forces reduced usage and slows acne recovery.

Individual hormone level Users with high DHT levels (severe hormonal acne, serious scalp baldness) require the full maximum cycle to see obvious changes.

Clascoterone is almost exclusively formulated into topical gels, creams and lotions for skin use; systemic absorption is extremely low, so systemic hormonal adverse reactions are rare. Most side effects are mild local skin irritation at the application site.

1. Common Local Skin Reactions (Mild & Transient)

These usually emerge within the first 2–4 weeks of continuous use and gradually fade as skin adapts:

Dryness, tightness and peeling of the treated skin

Mild erythema, redness and flushing

Slight burning, stinging or itchy sensation right after application

Scalp dryness and dandruff when used on the scalp for hair loss

Risk factors for aggravated local irritation: Over-daily application, mixing with high-concentration exfoliants (salicylic acid, retinol), use on broken, wounded or eczematous skin.

2. Uncommon Mild Cutaneous Side Effects

Less frequent adverse skin responses reported in clinical trials:

Folliculitis (small red inflamed bumps around hair pores)

Skin atrophy (rare, only with ultra-long-term overuse of high-concentration clascoterone formulations)

Temporary lightening or darkening of local skin tone

3. Rare Systemic Side Effects (Extremely Low Incidence)

Due to minimal transdermal penetration into blood circulation, whole-body hormonal disturbances seldom occur, unlike oral anti-androgens:

Rare mild headache

No significant changes to serum testosterone, DHT, estrogen or progesterone levels in most users

No sexual dysfunction, breast tenderness or menstrual irregularities for women (these typical side effects of oral anti-androgens are almost absent)

Only patients applying large coverage areas of concentrated clascoterone daily for months may experience subtle systemic hormone shifts.

4. Severe Hypersensitivity Reactions (Very Rare)

A tiny subset of people show allergic contact dermatitis to clascoterone or formula excipients:

Severe persistent itching, swollen skin, blisters or oozing lesions

Generalized facial rash after facial application Once severe allergy occurs, discontinue all use and clean the affected skin thoroughly; seek dermatological treatment if symptoms worsen.

5. Special Population Safety Risks

Pregnant and breastfeeding women Long-term clinical safety data for gestation and lactation is insufficient. Avoid widespread facial/scalp application to prevent tiny amounts from entering systemic circulation and affecting fetal/infant hormone development.

Children under 12 years old Skin barrier is immature, more prone to severe dryness and irritation; use only under strict doctor supervision.

Patients with chronic inflammatory skin diseases (atopic dermatitis, rosacea) Damaged skin barrier increases transdermal absorption and irritation risk; start with low-concentration formulations.

6. Drug Combination Irritation Risks

Concomitant use with the following topical ingredients amplifies dryness, stinging and peeling:

Retinoids (tretinoin, retinol)

High-dose salicylic acid, glycolic acid and other chemical exfoliants

Benzoyl peroxide If combined treatment is required, stagger application times or reduce the frequency of clascoterone use.

Clascoterone powder is a pharmaceutical raw material intended only for external topical formulations, never for oral ingestion. It needs to be dissolved and compounded into creams, gels, serums, scalp lotions or ointments before skin application.

1. Basic Formulation Concentration Guidelines

For acne facial preparations

Standard finished product concentration: 1% clascoterone (w/w) This is the FDA-approved therapeutic strength for moderate acne vulgaris.

For scalp anti-hair loss & seborrheic dermatitis formulas

Common concentration range: 0.5% – 1% 0.5% for sensitive scalps; 1% for severe oily scalp and androgenic alopecia.

Avoid high concentration over 1.2%

Higher strength drastically increases risks of skin dryness, stinging and peeling without extra efficacy gains.

2. Dissolution & Compounding Steps

Solvent selection Clascoterone dissolves well in ethanol, propylene glycol, glycerin and medium-chain triglycerides (MCT oil). It is barely soluble in pure water.

Dissolving process Weigh precise clascoterone powder and add it to the oil/alcohol co-solvent; stir gently under low temperature until fully transparent without undissolved precipitate.

Emulsification Mix the drug-containing oil phase with aqueous phase, add emulsifiers, moisturizers and soothing ingredients (panthenol, allantoin) to reduce skin irritation.

Homogenize and fill into gel/cream tubes.

3. Standard Topical Application Method (Finished Compound Products)

Application for facial acne

Clean and pat skin fully dry.

Apply a thin uniform layer of clascoterone gel/cream onto acne-prone areas (forehead, chin, cheeks) once or twice daily.

Avoid contact with eye mucosa, lip mucous membranes and broken wounds.

Do not apply heavy makeup right after use to prevent pore blockage.

Application for scalp hair loss & oily scalp

Shampoo hair and towel dry until slightly damp.

Dispense the scalp lotion and massage evenly into the hair roots and scalp skin.

Leave it on without rinsing off; use once daily at night.

4. Recommended Usage Cycle

Acne improvement: Visible reduction of pustules and oiliness after 4–6 weeks of consistent daily use; full stable effect at 12 weeks.

Hair loss control: At least 3–6 months of continuous scalp application to slow follicle miniaturization and lower shedding.

5. Critical Usage Precautions

External use only Strictly forbid oral intake; accidental swallowing may cause mild hormone disturbance and stomach upset.

Irritation reduction tips Do not combine with high-strength retinol, benzoyl peroxide or high-concentration fruit acid at the same time; stagger application or alternate days if combined therapy is necessary.

Special crowds limitation

Pregnant & lactating women: Minimize use or discontinue, lack complete long-term safety data.

Children under 12: Use only under dermatologist supervision with lower concentration formulas.

Storage of raw clascoterone powder Seal tightly, store in cool, dry and dark environment, avoid high temperature to prevent active ingredient degradation.

Handle raw powder safely during compounding Wear gloves and masks to prevent direct inhalation or prolonged skin contact with undiluted pure powder, which may cause local dryness and itch.

6. What to do if irritation occurs

If severe persistent redness, burning, peeling appears:

Reduce application frequency to once every other day.

Add more moisturizing soothing agents into the formulation.

Temporarily suspend use until skin barrier recovers.

Product list

Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

Hot Tags: pure clascoterone powder, China pure clascoterone powder manufacturers, suppliers, factory, Dihydroberberine for Insulin Sensitivity, Fenbendazole for Veterinary Worming, Loratadine for Sinus Pressure Relief, Pantethine for Energy Boost, Povidone Iodine for Surgical Wound Care, Zinc Bacitracin for Infection Control