S-Adenosyl-L-methionine Disulfate Tosylate

S-adenosine-l-methionine p-toluenesulfonic acid sulfate, also known as p-toluenesulfonic acid disulfonic acid adenosine methionine, abbreviated as SAMe, is a kind of chemical.

In animals, plants and microorganisms, SAMe is an important intermediate metabolite and physiologically active substance, composed of the combination of methionine and adenosine triphosphate. Meanwhile, in the human body, SAMe participates in various biochemical reactions and is the active precursor of sulfur-containing compounds such as glutathione, cysteine, taurine, and coenzyme A.

1.Used for Medicine

S-Adenosyl-L-methionine disulfate tosylate,As a pharmaceutical intermediate, it has unique biochemical functions as a methyl donor and precursor molecule.

It can enhance the stability of neuronal cell membranes by promoting the synthesis of neurotransmitters. It is used for the treatment and adjuvant therapy of various clinical diseases, and is involved in depression, arthritis, alcoholic liver injury, drug-induced liver injury, as well as symptoms that can relieve central pain perception and improve sleep quality.

2.Used for Dietary supplement

1)When S-Adenosyl-L-methionine disulfate tosylate is used in combination with glutathione, which has antioxidant effects, it can relieve mild depression, anxiety or mood disorders. The recommended dose is 200-400 mg/day and it should be taken in divided doses after meals.

2)Support liver detoxification

It can help eliminate free radicals and toxins produced by alcohol and drug metabolism. For people who drink alcohol and take medication for a long time, it is recommended to use capsules in combination with S-Adenosyl-L-methionine disulfate tosylate and silymarin. The recommended dose is 200-400mg/day.

Xi'an Tongze can provide formulas for production. The following capsules and gummy candies are formulated based on the data from our laboratory.

1.SAMe is the only molecule in the human body that can directly provide the active methyl group (-CH₃), without the need for multi-step enzymatic conversion like folic acid and betaine, and thus has higher efficiency.

2.S-Adenosyl-L-methionine disulfate tosylate, with its metabolic products being adenosine and methionine, both of which are inherent components of the human body. Therefore, if used for a long time, the side effects on the liver and kidneys are less than those of other synthetic drugs.

3.Most of the capsules available on the market nowadays are made of gelatin, which dissolves quickly in gastric juice and is not friendly to vegetarians. People with allergies should not use them. The S-Adenosyl-L-methionine disulfate tosylate capsule is used for oral administration and has a higher bioavailability than the common one. Meanwhile, the enteric-coated plant fiber capsules we have selected can better avoid the damage to gastric acid.

4.S-Adenosyl-L-methionine disulfate tosylate can be used in combination with N-acetylcysteine to enhance antioxidant capacity.

By reducing the levels of oxidative products such as malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) in cell membranes and lipoproteins, the lipid peroxidation is achieved, while increasing the content of reduced glutathione (GSH), and maintaining the intracellular redox equilibrium.
It has a relieving effect on osteoarthritis relief, which can reduce oxidative damage to joint cartilage, inhibit inflammatory mediators, and delay cartilage degeneration.

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