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Product Name |
ARA-290(Cibinetide) |
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Other Name |
ARA-290 (Cibinetide);ARA290,Cibinetide |
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Appearance |
White to off-white powder |
|
Sequence |
Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
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Assay |
99% by HPLC |
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Molecular Formula |
C₅₁H₈₄N₁₆O₂₁ |
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CAS Number |
1208243-50-8 |
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Solubility |
H2O/DMSO |
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Storage |
Cool dry place( Store at -20°C, away from the light) |
Products Description
What is ARA-290(Cibinetide)?
ARA-290 (Cibinetide) is an innovative synthetic, non-erythropoietic, linear 11-amino acid peptide currently in clinical development. Its sequence is inspired by erythropoietin (EPO) but has been specifically engineered to retain only EPO's tissue-protective and tissue-repairing properties while eliminating its hematopoietic (red blood cell-stimulating) effects. This means it does not increase hematocrit levels like EPO, thereby avoiding associated thrombotic risks. It has garnered attention for its unique mechanism of action and potential therapeutic applications across multiple diseases.
Xi 'an Tongze can provide other peptide products, the catalog is as follows, welcome to consult!
|
Product Name |
CAS No. |
|
Goralatide |
127103-11-1/120081-14-3 |
|
ARA-290(Cibinetide) |
1208243-50-8 |
|
N-acetyl Semax Amidate |
2920938-90-3 |
|
N-AC-selank-amidate |
N/A |
|
Aviptadil Acetate |
40077-57-4 |
|
GLP-1(1-37) |
87805-34-3 |
|
GIP (huMan) |
100040-31-1 |
|
N-Acetyl-Semax |
N/A |
|
N-Acetyl Selank |
N/A |
|
S-Phenylacetyl Larazotide |
N/A |
|
Dermorphin |
77614-16-5 |
|
PEG-MGF |
N/A |
|
Met-enkephalin |
58569-55-4 |
|
Pramlintide Acetate |
196078-30-5 |
|
Dalargin |
81733-79-1 |
|
Abaloparatide |
247062-33-5 |
|
N-Acetyl Larazotide |
N/A |
|
Humanin |
330936-69-1 |
|
Adamax |
N/A |
COA of ARA-290(Cibinetide)
Application of ARA-290(Cibinetide)
Currently in the clinical development phase, Due to its mechanism of action focused on repair and anti-inflammation, ARA-290 is being studied for the treatment of multiple diseases associated with tissue damage, neuropathy, and chronic inflammation:
1) Diabetic Neuropathy: This is one of its most extensively researched areas. Clinical trials demonstrate that ARA-290 significantly reduces pain, improves sensory function, and enhances quality of life in patients with small fiber neuropathy. Small fiber neuropathy is a common diabetic complication causing pain, numbness, and autonomic dysfunction.
2) Sarcoidosis: A systemic disease characterized by granulomatous inflammation. Clinical trials indicate ARA-290 holds potential for alleviating sarcoidosis-related neuropathic pain and improving patient symptoms.
3) Other Neuropathic Conditions:
Complex Regional Pain Syndrome (CRPS)
Chemotherapy-Induced Peripheral Neuropathy
HIV-Associated Neuropathy
4) Autoimmune and Inflammatory Diseases:
Rheumatoid Arthritis (preclinical studies indicate anti-inflammatory and joint-protective effects)
5) Metabolic Disorders:
Non-Alcoholic Steatohepatitis (NASH)
Improvement of Insulin Resistance
Benefits of ARA-290(Cibinetide)
1)Precision Targeting
The function of ARA-290 does not rely on the traditional EPO receptor but specifically binds to and activates the aforementioned IRR receptor. The activation of IRR triggers a series of intracellular signaling pathways (such as JAK2/STAT3, PI3K/Akt, MAPK), which govern anti-inflammatory, anti-apoptotic and pro-survival responses. This avoids the side effects of EPO (such as hypertension and thrombosis).
2)Multifunctionality
A single drug targeting a core mechanism may treat multiple distinct diseases that share chronic inflammation and tissue injury pathways.
3)Neuro-regenerative Potential
Beyond analgesia, it may promote repair of damaged nerves-a capability lacking in many existing therapies. Crucially, it directly acts on neurons and glial cells to stimulate axonal growth, reduce neuropathic pain, and modulate microglial activity.
4)Strong Safety Profile
ARA-290 has demonstrated favorable safety and tolerability across multiple clinical trials to date.
Summary and Evaluation of ARA-290(Cibinetide)
ARA-290 is a pioneering multi-functional repair peptide, and its core value lies in:
1.Mechanism innovation: The first therapeutic agent specifically targeting IRR
2.Therapeutic versatility: A single drug may address multiple pathological links.
3.Safety advantage: Avoids the main risks of EPO
4.Clinical need matching: Addressing neuropathies lacking effective therapies
Although still requiring Phase III clinical trials to confirm its efficacy and obtain regulatory approval, ARA-290 has demonstrated the potential as a novel class of therapeutic agent, which may offer unprecedented disease-modifying treatments for chronic inflammatory, neurodegenerative and metabolic disorders, rather than merely symptom relie
Important Notice: This document is compiled based on publicly available scientific research data. ARA-290 remains in the clinical trial phase and has not received formal marketing approval in any region worldwide. All therapeutic applications must adhere to the clinical trial protocol or future approved indications.
Packing & Shipping
Customer Feedback
FAQ
FAQ
Q: Can we offer Related products of ARA-290(Cibinetide)?
A: Yes, We can provide all products related to ARA-290(Cibinetide), welcome to consult!
Q: MOQ is ARA-290(Cibinetide)?
A: Moq is 1gram.
Q:Can customized packaging be carried out of ARA-290(Cibinetide)?
A:Of course, it can be repackaged. For instance, it is commonly used in vials or freeze-dried powder bottles for beauty purposes. We can provide them all.
Q:Is there a discount?
A:Of course, welcome to contact us. Price would be different based on different quantity. For bulk quantity, we will have discount for you.At the same time, we have a detailed list of discounted products and products with large inventory every quarter.
Q:Whether customized services can be provided
A:We offer ODM/OEM services and can manufacture according to specified formulations. We have our own designers who can design and customize private brands, packaging. Our customized service from the production of raw materials, design of brands/packaging, to the production of customized packaging, and then to packaging, mailing packages, one-stop production line, welcome to visit.
CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
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