Aviptadil Acetate Peptides

Product Name:Aviptadil Acetate
Type:GMP peptides
Sequence:His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Le
CAS.NO:40077-57-4
Single Impurity(HPLC):1.0%
Peptide Content(N%):80%(by %N)
Acid content(HPLC):15.0%
Mass balance:95.0~105.0%
MW :3325.87
Formula :C147H238N44O42S
Purity(HPLC):98.0%
Appearance:White powder
Amino Acid Composition:10% of theetical
Water content(Karl Fischer):6.0%
Vasoactive intestinal peptide (VIP) is widely distributed inthe body and is believed to occur throughout the gastrointestinaltract. It is a 28-residue polypeptide with structuralsimilarities to secretin and glucagon. It causes vasodilatationand increases cardiac contractibility. VIP stimulates bicarbonatesecretion, relaxes gastrointestinal and othersmooth muscles, stimulates glycogenesis, inhibits gastricacid secretion, and stimulates in sulin secretion. Its hormonaland neurotransmitter role has been investigated.

Aviptadil Acetate is a synthetic peptide analog of vasoactive intestinal peptide (VIP), a naturally occurring neuropeptide in the glucagon-growth hormone-releasing factor superfamily. The acetate salt formulation enhances its stability and bioavailability, making it suitable for clinical and research use. It exerts biological effects by binding to VIP receptors, which are widely distributed in the respiratory, cardiovascular, and immune systems.

Vasodilation: Acts as a potent systemic and pulmonary vasodilator by relaxing vascular smooth muscle cells, reducing vascular resistance, and improving blood flow.

Anti-proliferative Effects: Inhibits the proliferation of pulmonary arterial smooth muscle cells (PASMCs) and reduces intracellular calcium mobilization, which is critical for treating conditions characterized by excessive vascular remodeling.

Anti-inflammatory & Cytoprotective Properties: Suppresses matrix metalloproteinase (MMP) activity and caspase-3 activation, protecting lung epithelial cells from damage caused by cigarette smoke extract (CSE) or lipopolysaccharide (LPS). It also reduces platelet aggregation and attenuates inflammatory responses in alveolar macrophages.

Respiratory Diseases

Pulmonary Hypertension (PAH): Improves hemodynamic parameters by dilating pulmonary blood vessels and reversing vascular remodeling.

Pulmonary Fibrosis: Reduces lung tissue scarring by inhibiting fibroblast activation and extracellular matrix deposition.

COVID-19-related Respiratory Failure: Restores oxygenation in critically ill patients by improving lung perfusion and reducing cytokine-mediated lung injury.

Gastrointestinal Disorders: Inhibits gastric acid secretion, promotes intestinal fluid secretion, and relaxes gastrointestinal smooth muscle, potentially benefiting patients with inflammatory bowel disease or functional gastrointestinal disorders.

Cardiovascular Conditions: May help manage heart failure by reducing afterload and improving cardiac output through systemic vasodilation.

Aviptadil acetate is for parenteral administration only; oral administration is not effective due to rapid enzymatic degradation in the digestive tract. All dosages are for reference, and must be prescribed and adjusted by clinicians.

For respiratory distress and acute lung injuryStandard intravenous infusion: The typical daily dose ranges from 200–400 mcg, given via continuous intravenous infusion over 24 hours. The treatment course is determined according to the patient's clinical symptoms.

Adjunct use for related inflammatory conditionsSingle intravenous bolus dose: 100–200 mcg, administered slowly. The dosing frequency depends on disease severity and individual response.

Aviptadil acetate is a prescription drug. Improper use may cause hypotension, gastrointestinal discomfort and other adverse reactions. It is contraindicated for patients with known hypersensitivity to the drug. All medication shall comply with professional medical instructions.

Aviptadil acetate is a synthetic peptide corresponding to vasoactive intestinal peptide (VIP). It acts by binding to specific VIP receptors distributed throughout the lungs, blood vessels, nervous system and immune system.

It relaxes smooth muscles of the bronchi and pulmonary blood vessels, which dilates airways and improves pulmonary blood circulation, thus enhancing respiratory function. Meanwhile, it suppresses excessive inflammatory responses, relieves pulmonary tissue edema and oxidative damage, and protects pulmonary epithelial and endothelial cells. It also modulates immune cell activity to alleviate lung injury caused by inflammation.

Common Side Effects

Cardiovascular reactions: Transient hypotension, flushing, tachycardia. These usually occur shortly after administration and are mild and reversible.

Gastrointestinal symptoms: Nausea, vomiting, abdominal distension and mild diarrhea.

Local reactions: Redness, swelling or soreness at the injection site for parenteral use.

Less Common Side Effects

Respiratory discomfort: Mild cough, transient shortness of breath.

Systemic symptoms: Dizziness, fatigue, headache.

Metabolic changes: Slight decrease in blood glucose in individual patients.

Rare but Severe Adverse Reactions

Severe hypotension: May lead to syncope, especially in patients with unstable cardiovascular conditions.

Hypersensitivity reactions: Rash, urticaria, pruritus; very rarely anaphylaxis.

Severe gastrointestinal disturbances: Severe vomiting or persistent abdominal pain.

Special Notes

Side effects are generally dose-related. Adverse reactions are more likely to appear if the infusion rate is too fast or the dose is excessive.

Patients with pre-existing heart disease, hypotension or gastrointestinal disorders need close monitoring during medication.

Any persistent or severe discomfort must be reported to medical staff immediately.

Other Nootropics Raw Material Also Available

Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

Hot Tags: aviptadil acetate peptides, China aviptadil acetate peptides manufacturers, suppliers, factory, 4 Aminobenzoic Acid for UV Protection, Clotrimazole Antifungal Powder Bulk, Fenbendazole for Animal Health Care, Larazotide for Leaky Gut Treatment, Melatonin for Restorative Sleep, Methylene Blue for Research