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Product Name: |
Diosmin Powder |
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Plant Source: |
Citrus aurantium Extract |
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Molecular Formula |
C28H32O15 |
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Appearance: |
Yellow powder |
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Specification: |
99% |
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CAS Number: |
520-27-4 |
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Grade |
Pharmaceutical grade/Food Grade |
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Test Method |
UV/HPLC |
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Solubility |
Insoluble in water and ethanol. |
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Storage |
Keep from moisture and heat strictly but in a cool and dry place |
Products Description
What is Diosmin Powder?
Diosmin is a flavonoid compound, mainly produced by the one-step iodine dehydrogenation of hesperidin. Plant-based flavonoids are a class of important natural products with a wide range of biological activities, such as antioxidation, anti-inflammation, anti-mutagenesis and anti-cancer, and Diosmin is one of the outstanding ones among them.
Diosmin, as a typical flavonoid compound, is mostly produced by the one-step iodine dehydrogenation of hesperidin, which is a flavonoid that is abundant in citrus fruits. The diosmin we commonly use nowadays is derived from citrus fruits.
The origin of Diosmin
Diosmin is derived from the natural components of citrus plants. It is transformed into Diosmin through chemical treatments such as dehydrogenation of hesperidin. This method is both cost-effective and highly efficient. It combines the characteristics of both natural sources and industrial synthesis, and is highly recognized by the market.

COA of Diosmin Powder
Certificate Of Analysis
| Product: | Diosmin | ||
| Manufacturing Date | 2024/12/19 | Batch No. | DS241219 |
| Expiry Date | 2026/12/18 | Batch Size | 1,000 kg |
| Specification: Ph. Eur. 11.0 | ||
| Nature of Test | Specifications | Test Results |
| CHARACTERS | ||
| - Appearance | Greyish-yellow or light yellow hygroscopic powder. | Light yellow hygroscopic powder. |
| - Solubility | Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides. | Conforms |
| IDENTIFICATION | ||
| A. Infrared absorption spectrophotometry | Comparison: diosmin CRS | Conforms |
| B. Examine the chromatograms obtained in the Assay | The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a). | Conforms |
| TESTS | ||
| - Iodine | ≤ 0.1% | < 0.1 % |
| - Related substances (HPLC) | ||
| -- impurity A: acetoisovanillone | ≤ 0.5 % | 0.05 % |
| -- impurity B: hesperidin | ≤ 4.0 % | 0.17% |
| -- impurity C: isorhoifolin | ≤ 3.0 % | 0.64% |
| -- impurity D: 6-iododiosmin | ≤ 0.6 % | 0.06 % |
| -- impurity E: linarin | ≤ 3.0 % | 0.69% |
| -- impurity F: diosmetin | ≤ 2.0 % | 0.63 % |
| -- unspecified impurities, for each impurity | ≤ 0.4 % | 0.16 % |
| -- total | ≤ 8.5 % | 2.2% |
| - Heavy metals | ≤10ppm | Conforms |
| - Water | ≤ 6.0 % | 4.3 % |
| - Sulphated ash | ≤ 0.2 % | 0.10 % |
| ASSAY by HPLC | 90.0%-102.0% | 93.6 % |
| PARTICLE SIZE DISTRIBUTION | 100% pass 80 mesh sieve | 100% pass 80 mesh sieve |
| RESIDUAL SOLVENTS | ||
| - Methanol | ≤ 3000 ppm | 0 ppm |
| - Ethanol | ≤ 5000 ppm | 0 ppm |
| - Pyridine | ≤ 200 ppm | 23 ppm |
| MICROBIOLOGICAL TESTS | ||
| - Total aerobic microbial count | ≤ 103 CFU/g | < 10 CFU/g |
| - Total yeasts and moulds count | ≤ 102 CFU/g | < 10 CFU/g |
| - Escherichia coli | Absent in 1 g | Absent in 1 g |
| CONCLUSION: THE TEST RESULTS CONFORM TO Ph. Eur. 11.0. | ||
| STORAGE: In an airtight container. In dry, cool place protected from light. | ||
Application of Diosmin Powder
1.It is widely used in the clinical field to treat various symptoms related to venous lymphatic dysfunction: heavy legs, pain, and discomfort of soreness and distension in the morning. Acute hemorrhoids attack, lymphedema related to various symptoms.
2.In health care product ,Diosmin is often used in compound formulas with hesperidin, vitamin C and grape seed extract/horse chestnut extract. The common product forms are tablets or capsules, and the recommended intake is 450-900mg per day.It is suitable for people who sit or stand for long periods of time, those with increased venous pressure during pregnancy, as well as those with leg soreness or edema.
Special note: The intake of health supplements should be lower than that of medicines.


3.Its application in food additives is not very widespread. It mainly focuses on enhancing the flavor and color of functional beverages and foods. Especially when used in citrus beverages, it enhances the flavor and harmonizes the color.
Diosmin of Advantage
1. Source: Naturally occurring, mainly extracted from citrus plants (oranges, lemons), often coexisting with hesperidin. It is prepared through the chemical dehydrogenation reaction of hesperidin. This semi-synthetic method is more suitable for the market, with low cost and high efficiency.
2. Pharmacological effects:
1) It protects veins, inhibits inflammation, reduces capillary permeability, and decreases the formation of edema.
2) Antioxidant effect: It can eliminate free radicals, inhibit lipid peroxidation and protect vascular cells.
3)Synergistic effect: It can be used in combination with antioxidant products (such as vitamin C, grape seed extract, curcumin, etc.), and when compounded in capsules or tablets, it can better enhance the effect and bioavailability.
3.Low toxicity: It can be used for a long time, has relatively high safety, is suitable for the management of chronic diseases, but not for acute symptoms
4.Double protection: It has both vascular strengthening and anti-inflammatory and antioxidant functions.
Why Choose Us
1.We have our own factory and professional R&D personnel.
2. We have 10 years of experience in foreign trade export.
3. It has a professionally managed CRM system and dedicated logistics staff (warehouse managers, freight department).
4. We offer specific OEM/ODM services, providing a one-stop assembly line service from formula research and development, private brand design, production to packaging
5.We offer product testing certificates such as HALAL,FDA,HACCP,GMP,ISO series, and third-party certifications as per your requirements.



OEM/ODM Service

Customer Feedback


FAQ
Q: Can we offer Related products of Diosmin Powder?
A: Yes,We supply vitamin C, hesperidin and products extracted from citrus fruits.
Q: How do you treat quality complaint ?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q:Can I get free sample of Diosmin Powder?
A:Yes, free sample is 20grams,but the receiver need to pay for the shipping cost.
Q: Is there any discount Diosmin Powder?
A: Yes, for larger quantity, we always support with better price. There will be promotional activities every quarter, including best-selling products and products in large inventory.
Q:How to start an order with us?
A:Our can give us the P/O after confirming each other, We will send you Proforma Invoice
Q:Can customized services be provided of Diosmin Powder Powder?
A:Of course, we have our own custom production workshop, capsules and tablets which can provide a full range of services from raw material powder/extract liquid, custom formula, packaging design to shipment. Welcome to consult Alice email:alice@xaheshun.com
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