| Product Name | Hypromellose Acetate Succinate |
| Common Name | Hypromellose Acetate Succinate (HPMCAS) |
| CAS No. | 71138‑97‑1 |
| Appearance | White to slightly yellow powder / fine granules, slight acetic‑acid odour |
| Hydroxypropoxy Purity | 4.0‑23.0 % |
| Pharmacopoeia Standard | USP‑NF, JP, EP, ChP |
| Solubility | Insoluble in pure water & gastric fluid |
| Certification | FDA,GMP,ISO,MSDS |
| Packga | 25 kg fibre drum with inner PE liner; small lab sample: 100 g‑5 kg aluminium foil bag |
| Storage | Keep sealed, dry, cool, avoid moisture, direct sunlight and high temperature; hygroscopic material |
| Shelf-Life | 24Months |
Products Description
What Is Hypromellose Acetate Succinate?
Hypromellose Acetate Succinate (HPMCAS, CAS 71138‑97‑1) is compendial‑grade cellulose‑based enteric polymer excipient compliant with USP‑NF. Available in LG, MG, HG grades with pH‑responsive solubility. Mainly used for enteric coating and solid dispersion carrier to boost bioavailability of poorly soluble drugs for pharmaceutical formulation.
Similar Pharmaceutical Excipients to HPMCAS,see below :
| Product Name | CAS No. |
| Hypromellose Phthalate (HPMCP) | 9050‑31‑1 |
| Cellulose Acetate Phthalate (CAP / Cellacefate) | 9004‑38‑0 |
| Polyvinyl Acetate Phthalate (PVAP) | 34481‑48‑6 |
| Methacrylic Acid Copolymer Type A (Eudragit L series) | 25086‑15‑1 |
| Methacrylic Acid Copolymer Type B (Eudragit S series) | 25086‑15‑1 |
| Kollicoat MAE 100P (Methacrylic acid‑ethyl acrylate copolymer) | 52947‑94‑1 |
| Soluplus (Polyvinylcaprolactam‑polyvinyl acetate‑polyethylene glycol graft copolymer) | 88504‑27‑2 |
Applications Of Hypromellose Acetate Succinate
1. Pharmaceutical Industry (Primary Main Application, Pharmaceutical‑Grade Only)
As a pharmacopoeia‑grade polymer excipient meeting USP‑NF, EP and JP requirements, Hypromellose Acetate Succinate is used for enteric coating on tablets, pellets and granules, amorphous solid‑dispersion carrier for poorly‑soluble drugs (spray‑drying, hot‑melt extrusion), modified‑release preparations, microcapsules and pre‑formulation studies for generic & novel drugs.
It is a pharmaceutical excipient only, not an active ingredient. Actual application shall follow local regulatory requirements.
2.Nutraceutical & Functional Food Industry (Food‑Grade HPMCAS Required)
Authorized under FDA GRAS for dietary supplements only; prohibited for general food and infant formula. Applied for enteric coating of probiotic tablets/granules, micro‑encapsulation of vitamins & plant extracts, and film‑forming for supplement tablets. Local food regulation verification is required prior to commercial launch.
Food‑grade grade material is mandatory for above‑mentioned nutraceutical applications. Pharmaceutical‑grade material cannot be directly used for food production.
3.Cosmetics & Personal Care Industry (Cosmetic‑Grade)
Taking advantage of its film‑forming property, Hypromellose Acetate Succinate can be used for cosmetic capsules and controlled‑release matrix for active ingredients in serum systems. However, it is not a mainstream cosmetic raw material and occupies a low market share in personal‑care formulations.
Corresponding cosmetic‑grade specification is required. Users must comply with regional cosmetic regulatory standards before commercial application.
Core Formulation Benefits
1.Adjustable pH‑triggered intestinal release
Three commercial grades LG, MG, HG with different dissolution pH values, enable flexible site‑targeted release design for tablets, pellets and granules; protects acid‑sensitive actives against stomach fluid damage and reduces gastric irritation risk.
2.Excellent film‑forming performance
Forms tough, uniform enteric coating layer; works well for both water‑based and organic solvent coating processes, less brittleness risk versus traditional enteric polymers.
3.Powerful stabilization for amorphous solid dispersion
High glass‑transition temperature inhibits API recrystallization, sustains drug supersaturation; significantly boosts dissolution and bioavailability for poorly‑water‑soluble APIs. Compatible with hot‑melt‑extrusion (HME) and spray‑drying production technologiesPMC
Packing
| Order Type | Net Weight | Inner Packaging | Outer Packaging |
| Sample / Lab R&D | 100 g, 500 g | Vacuum‑sealed multi‑layer aluminium‑foil barrier bag | Aluminium‑foil bag placed into carton box with shock‑absorbing filler |
| Small‑batch commercial | 1 kg, 5 kg | Double‑layer vacuum‑sealed aluminium‑foil bag with desiccant | Pharmaceutical HDPE drum / fibre drum |
| Large‑bulk commercial | 25 kg | Double‑layer aluminium‑foil liner + desiccant inside | UN‑qualified pharmaceutical fibre drum |
Customer Feedback
CONTACT PAGE
We provide USP‑NF / EP / JP compliant HPMCAS including LG, MG, HG grades for R&D and mass production. Both samples and bulk quantities are available.
Please Contact us see below method to get your quote.
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q: What pharmacopoeia standards does your HPMCAS comply with?
A: Our pharmaceutical‑grade HPMCAS meets USP‑NF, EP and JP monograph requirements. Supporting test documents are available upon request.
Q: What is the solubility characteristic of HPMCAS?
A: Insoluble in gastric acidic fluid and pure water. Dissolves in intestinal buffer above grade‑specific pH. Soluble in acetone or ethanol‑dichloromethane mixed organic solvents.
Q:What supporting documents can you provide for HPMCAS?
A: COA, MSDS, TSE‑BSE statement, heavy‑metal & residual‑solvent test reports. DMF‑related supporting materials can be provided on request.
Q: Can HPMCAS be used for dietary supplement products?
A: Only food‑grade HPMCAS can be used for dietary supplements under FDA GRAS permission. It is prohibited for general food and infant formula. Local regulatory verification is required before commercial use.
Q: What are the correct storage conditions for HPMCAS?
A: HPMCAS is hygroscopic. Store sealed in cool, dry place, avoid moisture and direct sunlight. Reseal container quickly after opening to prevent caking.
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