|
Product Name |
Goserelin acetate |
|
Appearance |
White to off-white crystalline powder |
|
Assay |
99% by HPLC |
|
Molecular Formula |
C₆₁H₈₈N₁₈O₁₆ |
|
CAS Number |
145781-92-6 |
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Solubility |
Easy soluble in organic solvents (e.g., DMSO, ethanol). Low solubility in aqueous solutions; typically requires preparation of stock solutions in DMSO. |
|
Storage |
Cool dry place( Store at -20°C, away from the light) Wear appropriate personal protective equipment during operation to avoid inhalation or direct skin contact. |
Products Description
What is Goserelin acetate?
Goserelin Acetate is a synthetic decapeptide analogue of naturally occurring gonadotropin-releasing hormone (GnRH), also known as a LHRH agonist.
In clinical applications, it is a potent endocrine therapy agent. By inducing a transient increase in serum levels of LH and FSH, followed by a profound down-regulation of GnRH receptors, it effectively suppresses sex hormone production. This "medical castration" makes it a gold standard for treating:
Prostate Cancer (Advanced/Metastatic)
Breast Cancer (Endocrine-responsive)
Endometriosis and Uterine Fibroids
Xi 'an Tongze can provide other peptide products, the catalog is as follows, welcome to consult!
|
Product Name |
CAS No. |
|
Goralatide |
127103-11-1/120081-14-3 |
|
ARA-290(Cibinetide) |
1208243-50-8 |
|
N-acetyl Semax Amidate |
2920938-90-3 |
|
N-AC-selank-amidate |
N/A |
|
Aviptadil Acetate |
40077-57-4 |
|
GLP-1(1-37) |
87805-34-3 |
|
GIP (huMan) |
100040-31-1 |
|
N-Acetyl-Semax |
N/A |
|
N-Acetyl Selank |
N/A |
|
S-Phenylacetyl Larazotide |
N/A |
|
Dermorphin |
77614-16-5 |
|
PEG-MGF |
N/A |
|
Met-enkephalin |
58569-55-4 |
|
Pramlintide Acetate |
196078-30-5 |
|
Dalargin |
81733-79-1 |
|
Abaloparatide |
247062-33-5 |
|
N-Acetyl Larazotide |
N/A |
|
Humanin |
330936-69-1 |
|
Adamax |
N/A |
COA of Goserelin acetate
|
Product Name |
Goserelin acetate |
CAS Number |
145781-92-6 |
|
Manufacture Date |
2026/03/03 |
Expiration Date |
2028/03/02 |
|
Batch Number |
TZ20260303 |
Batch Quantity |
10G |
|
Item |
Specification |
Results |
|
Organoleptic Data |
||
|
Appearance |
White Powder |
White powder |
|
Odor &Taste |
Characteristic |
Conform |
|
Identification |
H-NMR |
Conform |
|
Solubility |
Soluble in water ≥100mg/m (H2O) |
Conform |
|
PH |
4.0-6.0 |
5.85 |
|
Physical Characteristics |
||
|
Purity (By HPLC) |
≥99.0% |
99.78% |
|
Water Content (Karl Fischer) |
≤0.5% |
0.1% |
|
Residual solvent |
Mlethanol≤0.2% |
No Detected |
|
Acetonitrile≤0.2% |
No Detected |
|
|
Triethylamine≤0.2% |
No Detected |
|
|
Bacterial endotoxin |
<10EU/mg |
<0.1EU/mg |
|
Total mold and yeast count |
<10cfu/g |
Conform |
|
Escherichia coli |
<10cfu/g |
No Detected |
|
Total aerobic bacteria |
<10cfu/g |
Conform |
|
Conclusion |
The product conforms with enterprise standard and qualified |
|
|
Packing |
Keep in dark and cool dry place ,2 to 8°C |
|
|
Storage |
Keep in dark and cool dry place |
|
|
Shelf life |
2 Years When Stored properly |
|
Storage & Handling OF Goserelin acetate
Storage: Keep in a tightly closed container, stored in a cool, dry, and well-ventilated place. Recommended storage temperature: -20°C for long-term stability.
Shelf Life: 24 months when stored under optimized conditions.
Therapeutic Applications & Industry Scenarios of Goserelin acetate
1. Oncology: Hormonal Manipulation in Cancer CareGoserelin Acetate is primarily utilized as a cornerstone in Androgen Deprivation Therapy (ADT) and Estrogen suppression.Advanced Prostate Cancer: It is the "Gold Standard" for achieving medical castration, reducing serum testosterone to levels $\leq 50$ ng/dL to inhibit tumor progression.Breast Cancer Management: Used in pre- and perimenopausal women with hormone receptor-positive (HR+) breast cancer to suppress ovarian estrogen production.
2. Gynecology: Estrogen-Dependent ConditionsPharmaceutical manufacturers source this API to develop treatments for chronic gynecological disorders:Endometriosis: By inducing a temporary "pseudo-menopause," it reduces endometrial lesions and alleviates associated pelvic pain.Uterine Fibroids (Leiomyomas): Applied as a preoperative treatment to reduce fibroid volume and vascularity, minimizing surgical risk and blood loss.Endometrial Thinning: Used as a thinning agent prior to endometrial ablation or resection surgeries.
3. Assisted Reproductive Technology (ART)In the field of fertility, Goserelin Acetate is employed for Pituitary Down-regulation. It prevents premature Luteinizing Hormone (LH) surges, allowing for controlled ovarian hyperstimulation during IVF cycles.
benefit of Goserelin acetate
1. Mechanism Of Action: The "LHRH Agonist"
Goserelin Acetate is a potent synthetic analogue of Gonadotropin-Releasing Hormone (GnRH). Its primary effect is the modulation of the HPG (Hypothalamic-Pituitary-Gonadal) axis.
Initial Phase (Flare Effect): Upon first administration, Goserelin induces a transient increase in serum levels of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).
Chronic Phase (Down-regulation): Continuous exposure leads to the desensitization of pituitary GnRH receptors. This results in a profound drop in LH and FSH secretion, leading to a significant reduction in sex steroid levels.
2. Pharmacological Characteristics
High Receptor Affinity: Goserelin has a higher affinity for the GnRH receptor than natural LH-RH, ensuring consistent hormonal suppression.
Long-acting Potential: The molecular stability of Goserelin Acetate allows for its incorporation into depot formulations (controlled-release implants) that provide therapeutic effects for 28 days or 3 months.
Why Source Our Goserelin Acetate?
1. Superior Impurity Profile
Our synthesis process utilizes advanced Solid-Phase Peptide Synthesis (SPPS) technology, ensuring rigorous control over diastereoisomers and truncated peptides. We provide comprehensive impurity characterization reports to facilitate your ANDA/DMF filings.
2. Global Compliance & Documentation
We operate under a strict cGMP quality management system. Full technical dossiers are available upon request, including:
DMF (Drug Master File)
Stability Studies (Long-term & Accelerated)
3. Scalability & Stability
With a dedicated peptide manufacturing facility, we offer batch sizes ranging from grams for R&D to multi-kilograms for commercial production. Our validated lyophilization process ensures the API remains stable and highly soluble for downstream formulation.
4. Specialized Cold-Chain Logistics
As Goserelin Acetate is temperature-sensitive, all shipments are packed in specialized thermal insulation with real-time temperature monitoring to ensure integrity from our warehouse to your lab.
Packing & Shipping
Why Choose Us
Customer Feedback
CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q: Can we offer Related products of Goserelin Acetate?
A: Yes, We can provide other peptides,welcome to consult.
Q: How do you treat quality complaint ?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q: Is your Goserelin Acetate API suitable for sustained-release implant formulations?
A:Absolutely. Our Goserelin Acetate API features optimized particle size distribution and high solubility, making it ideal for the development of sustained-release subcutaneous implants (such as 3.6mg or 10.8mg dosages) used in prostate and breast cancer therapies.
Q:Is there a discount?
A:Of course, welcome to contact us. Price would be different based on different quantity. For bulk quantity, we will have discount for you.At the same time, we have a detailed list of discounted products and products with large inventory every quarter.
Q:How do you ensure the stability of Goserelin Acetate during international shipping?
A:We utilize validated cold-chain logistics for all Goserelin Acetate shipments. The product is packed in specialized thermal insulation with gel packs or dry ice, accompanied by real-time temperature data loggers to ensure the API remains within the required temperature range throughout transit.
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