PE-22-28 PNC-27 Peptide Powder

PE 22-28 is a 7-amino acid short peptide (sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg) with CAS number 1801959-12-5. It is a derivative of the natural peptide Spadin, engineered to have enhanced stability and biological activity compared to its parent compound.

Potent TREK-1 Channel Inhibition

Exhibits high specificity for the TREK-1 two-pore potassium channel, with an IC₅₀ value of just 0.12nM, enabling precise blockade of channel activity

The TREK-1 channel is highly expressed in brain regions responsible for mood regulation (prefrontal cortex, amygdala, hippocampus), and its dysfunction is closely linked to depression

Rapid Antidepressant Effects

Animal studies show it can induce hippocampal neurogenesis in just 4 days, significantly faster than traditional SSRI antidepressants

Markedly reduces immobility time in mouse forced swimming tests and decreases latency to obtain food pellets in behavioral assays

Demonstrates far fewer side effects compared to conventional antidepressant medications

Neuroprotective Properties

Reduces β-cell apoptosis in ischemia models, improving motor and cognitive function deficits after stroke

Scavenges reactive oxygen species (ROS) and inhibits oxidative stress pathways, mitigating cellular damage

Stabilizes mitochondrial membrane potential, reduces mitochondrial swelling and cytochrome C release, and suppresses cell apoptosis

Anti-inflammatory and Repair Effects

Decreases inflammatory cytokine release, reducing inflammation-mediated secondary damage

Promotes cell survival and repair, offering protective effects on heart, brain, kidney, and endothelial cells

Depression Research

Serves as a lead compound for the development of novel antidepressant drugs

Used to investigate the pathogenesis of depression and underlying neuroregulatory pathways

Neurodegenerative Disease Research

Explored as a potential therapeutic target for diseases like Alzheimer's and Parkinson's

Facilitates research into learning disabilities and cognitive decline mechanisms

Stroke and Nerve Injury Research

Investigated for neuroprotective strategies in ischemic stroke

Used to study repair mechanisms in traumatic brain injury

Drug Development Platform

Serves as a core sequence for preparing analogs through chemical modification and amino acid substitution

Acts as a structural screening model for peptide-based organ protection candidate drugs

Cell Biology Research

Used to study mechanisms of cell protection, antioxidation, and anti-apoptosis

Aids in constructing oxidative stress injury models (ischemia, hypoxia, inflammation)

Facilitates research into redox regulation and mitochondrial function in signaling pathways

Storage Conditions: Short-term storage at 2~8℃ in sealed, light-protected containers; long-term storage recommended at -15~-20℃

Stability: Stable when stored frozen at -20℃ in the dark; avoid repeated freeze-thaw cycles

Packaging Specifications: 1g/bottle, 10g/bottle, 100g/bottle (in peptide-specific plastic containers)

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