KPV Peptide Powder

KPV peptide is a small peptide composed of three amino acids, with the sequence lysine-proline-valine. It represents the shortest bioactive C-terminal fragment of α-melanocyte-stimulating hormone (α-MSH), an important natural anti-inflammatory protein in the human body. KPV's most remarkable property is its potent anti-inflammatory and tissue-repairing effects, demonstrating particularly significant efficacy against intestinal inflammation. Consequently, it is considered a potential therapeutic agent for conditions such as inflammatory bowel disease.

Optimal Solvent: Sterile distilled water or buffered saline. This is the most physiologically compatible solvent suitable for most cellular experiments and animal studies. Advantages: Non-toxic, non-irritating, and highly compatible with biological systems.

Alternative Solvents: For higher concentrations or specific experiments, small amounts of dilute acetic acid or DMSO may be used.

Solvents to Avoid: Pure organic solvents such as acetonitrile, methanol, or chloroform.

The amino acid sequence of KPV is Lys-Pro-Val.

Lysine carries a positively charged amino group and is hydrophilic. Proline and valine are hydrophobic.

Despite containing hydrophobic amino acids, KPV exhibits high water solubility overall due to its extremely low molecular weight and the presence of charged hydrophilic groups. Its short-chain structure facilitates easier encapsulation and dissolution by water molecules.

Therefore, for long-term storage, it is recommended to aliquot into small portions and freeze at -20°C or lower at -80°C. Repeated freeze-thaw cycles significantly reduce the peptide's activity and stability.

bottle packing 

aluminium foil bag packing 

fine powder

KPV peptide is a tripeptide derived from α-MSH that exhibits potent anti-inflammatory and reparative activity. It is a highly promising molecular compound in scientific research, particularly for treating inflammatory bowel disease. Currently, it is primarily used in pharmaceutical research and partially incorporated into commercial supplements.

 

1.Used in the of Research drugs

 

Within the scientific and medical communities, KPV is strictly regarded as a candidate drug. It is undergoing rigorous preclinical studies and potential future clinical trials to demonstrate its safety, efficacy, and appropriate dosage for human use.

2.Used in the of Commercial Supplements

Currently, KPV peptides are also sold as dietary supplements in the market (particularly on certain online marketplaces), typically marketed for "gut health," "reducing systemic inflammation," or "skin health." As supplements, their purity, dosage, and quality are not subject to the stringent oversightof pharmaceutical regulatory bodies. Potential long-term side effects remain unclear.

1.Inhibition of the NF-κB pathway

NF-κB is a core transcription factor regulating inflammatory responses within cells. When activated, it initiates the production of multiple pro-inflammatory cytokines. KPV suppresses NF-κB activation, thereby reducing the release of inflammatory mediators at their source.

2.Activation of Melanocortin-1 Receptor

Although KPV exhibits lower affinity for melanocortin receptors compared to intact α-MSH, it can still trigger anti-inflammatory signaling by interacting with MC1R on immune cells.

3.Promoting Cell Migration

KPV has been shown to enhance migration of intestinal epithelial cells, which is crucial for repairing the intestinal mucosal barrier damaged by inflammation. It helps "heal the wound."

4.Regulating Cytokine Balance

KPV can reduce levels of pro-inflammatory cytokines while potentially increasing levels of anti-inflammatory cytokines, thereby shifting the inflammatory environment toward a reparative state.

A significant advantage of KPV is its oral bioavailability. Most peptide drugs are degraded by proteases in the gastrointestinal tract after oral administration. However, due to its unique structure, KPV resists degradation and is absorbed through the intestinal wall into the circulatory system or exerts its effects locally within the intestine. This makes oral administration a highly convenient and viable treatment option.

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2.Contact Information：
Name：Alice

Telephone :+8618509260106
Email:alice@xaheshun.com

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