Pure CMS121 Powder

Complete Product Specifications & Chemical Parameters

CMS121 Powder (CAS 1353224-53-9) is a high-efficiency, orally active small-molecule quinoline derivative, widely known as a selective Acetyl-CoA Carboxylase 1 (ACC1) inhibitor. With unique molecular structure and multi-target biological activity, CMS121 exhibits powerful neuroprotective, anti-inflammatory, antioxidant, and renal protective effects in preclinical and biochemical research. It has become a core tool compound for global laboratories to study neurodegenerative diseases, chronic inflammation, oxidative stress injury and renal metabolic regulation.

We are a professional factory supplier and exporter of high-purity CMS121 Powder. Adopting advanced chemical synthesis and high-precision purification technology, our CMS121 raw powder features ≥98% HPLC purity, ultra-low impurities, stable biological activity and excellent batch consistency. All products pass strict laboratory-level quality testing, with complete export qualification documents and flexible MOQ support. We provide sample trial orders and bulk wholesale services for university research labs, biotech R&D institutions, pharmaceutical companies and medical research teams worldwide. This product is for scientific research use only, not for human consumption, clinical diagnosis or treatment.

CMS121 is a highly selective, orally bioavailable ACC1 inhibitor with excellent cell permeability. Its unique quinoline-based molecular structure enables specific binding to ACC1 enzyme, effectively inhibiting ACC1 activity, elevating intracellular acetyl-CoA levels and activating AMPK signaling pathways. This core regulatory mechanism enables CMS121 to comprehensively regulate cellular energy metabolism, lipid synthesis, oxidative stress balance and inflammatory responses.

Different from ordinary broad-spectrum inhibitors, CMS121 features low off-target effects and high biological safety. It can effectively maintain intracellular glutathione (GSH) levels, reduce neuronal oxytosis and ischemia damage, inhibit microglial overactivation, and down-regulate the expression of pro-inflammatory factors such as TNF-α, iNOS and caspase-1. With dual regulation of metabolism and immunity, CMS121 has become a leading tool compound for neurodegeneration, renal injury and anti-aging mechanism research.

Benefiting from its superior neuroprotective, anti-inflammatory, antioxidant and renal protective activities, high-purity CMS121 Powder is widely applied in cutting-edge biomedical and pharmacological research fields, covering multiple high-value research scenarios:

3.1 Neurodegenerative Disease Research

CMS121 is a classic research compound for Alzheimer's disease and age-related neurodegeneration studies. It can effectively prevent glutamate-induced neuronal cell death, relieve neuronal oxidative damage and brain tissue oxytosis, improve the survival rate of hippocampal neurons, and delay cognitive function decline. It is widely used in the mechanism exploration of Alzheimer's disease, dementia intervention research and neuroprotective drug screening.

3.2 Anti-Inflammation & Microglial Activation Research

CMS121 can significantly inhibit LPS-induced microglial overactivation, with an inhibition rate up to 82% in N9 microglial models. It blocks the release of multiple pro-inflammatory cytokines, suppresses neuroinflammation and systemic chronic inflammatory responses, and reduces inflammatory tissue damage. It is an essential reagent for neuroinflammation mechanism verification, chronic inflammatory disease modeling and natural anti-inflammatory pathway research.

3.3 Oxidative Stress & Anti-Oxidation Research

As a powerful antioxidant compound, CMS121 maintains stable intracellular glutathione levels, scavenges excess reactive oxygen species (ROS), alleviates DNA and cell oxidative damage, and resists ischemia-induced oxidative injury. It is widely used in cellular antioxidant mechanism research, oxidative stress injury modeling and anti-senescence compound evaluation.

3.4 Renal Protection & Aging-Related Kidney Disease Research

CMS121 exhibits prominent renal protective effects in aging animal models. It effectively reduces kidney weight loss, down-regulates the expression of renal injury-related proteins such as TNF-α and caspase-1, improves renal metabolic function, and relieves chronic kidney damage caused by aging. It is a key research material for exploring senile nephropathy mechanisms and renal metabolic regulation pathways.

3.5 Cellular Energy Metabolism & Lipid Metabolism Research

By inhibiting ACC1 activity and activating AMPK signaling, CMS121 regulates intracellular lipid synthesis and energy metabolism balance. It is widely used in cell energy metabolism research, lipid metabolic disorder modeling, and pharmacological mechanism research of metabolic regulatory drugs.

3.6 Neural Cell Differentiation & Neurological Repair Research

CMS121 can induce the differentiation of PC12 neural cells, promote nerve cell repair and regeneration, and improve neuronal functional activity. It is applied in neural development research, nerve injury repair mechanism exploration and neural cell physiological regulation experiments.

3.7 Preclinical Drug Development & Target Verification

Pharmaceutical R&D institutions use high-purity CMS121 as a standard positive inhibitor for ACC1 target verification, new drug efficacy evaluation, and preclinical pharmacological research. It provides reliable compound support for the development of neuroprotective drugs, anti-inflammatory preparations and anti-aging drug candidates.

Compared with ordinary CMS121 Powder on the market, our products have obvious competitive advantages in purity, activity stability, batch consistency and technical service, which are highly recognized by global scientific research institutions and biotech enterprises:

High Purity & Ultra-Low Impurities: Adopt multi-step synthesis and recrystallization purification technology, HPLC verified purity ≥98%. Strictly control heavy metals, residual solvents and unknown impurities, completely avoid experimental data interference, and meet high-standard preclinical and biochemical research requirements.

Stable Biological Activity: Standardized low-temperature synthesis and sealed production process retain the maximum biological activity of CMS121. The neuroprotective, anti-inflammatory and antioxidant effects of each batch are stable, with negligible batch-to-batch difference.

High Target Specificity: Precise selective inhibition of ACC1, low off-target activity, accurate experimental effect, suitable for high-precision target mechanism research and drug screening experiments.

Complete Qualification Documents: Provide full set of supporting materials including COA quality certificate, HPLC test report, NMR spectrum, MSDS safety data sheet and export customs clearance documents, convenient for customer laboratory filing and project research.

Flexible Global Supply: Adequate spot inventory all year round, supporting 1g-10kg flexible customized supply. Support small sample trial orders for experimental verification and large-batch bulk orders for long-term research projects.

Professional Technical Support: Provide professional guidance on product dissolution ratio, storage methods, experimental dosage and operation precautions, solving various technical problems in customer research application.

Standard Packaging Options

Sample Packaging: 1g / 5g / 10g vacuum-sealed aluminum foil bag, moisture-proof, light-proof and oxidation-resistant, suitable for laboratory trial experiments

Small Batch Packaging: 50g / 100g / 500g sealed high-purity plastic bottle, safe for short-term storage and daily experimental use

Bulk Packaging: 1kg / 5kg professional chemical drum with double-layer sealing and moisture-proof film, suitable for long-distance transportation and long-term project research

Custom Service: Support personalized packaging and specification customization according to customer exclusive research needs

Global Shipping & Delivery

We cooperate with top international logistics companies to provide safe, fast and stable cross-border transportation services. Small sample orders are delivered by DHL, FedEx, UPS and TNT international express, with delivery time of 3-7 working days. Large-batch goods adopt air freight or sea freight, with complete customs clearance documents and professional cargo protection measures. We support FOB, CIF, DDP and other international trade modes, covering most countries and regions worldwide, realizing one-stop door-to-door delivery and eliminating customers' logistics and customs clearance troubles.

We always adhere to strict quality control standards for biochemical research reagents. All CMS121 Powder CAS 1353224-53-9 products are produced in strict accordance with international laboratory reagent production specifications. We have established a complete quality traceability system, with strict inspection in every link of raw material synthesis, purification processing, finished product testing and packaging storage, to ensure stable and reliable product quality.

We provide 24-hour online professional customer service and technical support. Our professional pharmacological and biochemical technical team can answer customers' questions about product properties, experimental application schemes, storage management and activity verification at any time. For product quality problems caused by our production process, we support unconditional replacement and full refund to fully protect the legitimate rights and interests of every global customer.

With years of experience in the R&D, production and export of high-end biochemical reagents and small-molecule inhibitor compounds, we have established long-term stable cooperative relations with hundreds of global university laboratories, medical research institutions and biotech companies. We focus on providing high-purity, high-activity and cost-effective research compounds and one-stop raw material procurement solutions for global scientific researchers.

Different from ordinary suppliers, we not only provide high-quality CMS121 Powder with zero batch difference and stable activity, but also provide professional pre-sales experimental guidance, customized specification services and long-term stable supply guarantee. Adhering to the business philosophy of integrity management and quality-oriented, we strictly control every product detail to provide reliable raw material support for customers' scientific research and drug development projects.

Important Product Statement

CMS121 Powder (CAS 1353224-53-9) is only for scientific laboratory research and experimental study. It is not suitable for human consumption, clinical medical application, food, drug or cosmetic addition and daily use.

Get Free Sample & Latest Wholesale Quotation

If you are looking for a reliable and stable supplier of high-purity CMS121 Powder CAS 1353224-53-9 ACC1 inhibitor compound, welcome to contact us for free product samples, detailed COA test reports, customized specifications and the latest factory wholesale price. We will provide you with the most competitive price and professional one-stop service, and look forward to establishing long-term win-win cooperative relations with global partners!

CMS121 Powder has been widely adopted in peer-reviewed preclinical studies and laboratory validation projects. The following are typical, authoritative application cases based on published biomedical research, which fully demonstrate the practical research value and stable pharmacological activity of our high-purity CMS121 compound:

Case 1: Aging-Related Metabolic Dysfunction & Obesity Intervention Research

In published aging metabolism studies, researchers utilized high-purity CMS121 Powder to intervene in aging-induced fat accumulation and metabolic decline models. Experimental results verified that selective ACC1 inhibition by CMS121 effectively reprograms cellular energy metabolism toward ketogenic metabolism, significantly reducing body fat deposition and improving age-related obesity symptoms. Meanwhile, CMS121 optimized lipid metabolite levels in vivo, reduced abnormal acylcarnitine accumulation, and improved overall metabolic homeostasis. This case proves CMS121's core research value in anti-aging metabolism, weight regulation and geriatric metabolic disease mechanism exploration.

Case 2: Diabetes & Hepatorenal Protection Preclinical Model Research

In classic db/db diabetic mouse models, CMS121 Powder was applied to study diabetic multi-organ complications. After continuous CMS121 intervention, experimental animals showed significantly improved glucose tolerance, reduced HbA1c and fasting insulin levels, and relieved insulin resistance. In terms of organ protection, CMS121 effectively reduced liver inflammatory infiltration, lowered hepatic lipid deposition, and alleviated aging and diabetes-induced renal pathological damage, down-regulating the expression of renal injury markers TNF-α and caspase-1. This typical application case confirms that CMS121 is a key tool compound for diabetes complication, fatty liver and diabetic nephropathy preclinical research.

Case 3: Neuroinflammation & Neurodegeneration Protection Experiments

In neurobiology laboratory research, CMS121 Powder was used in LPS-induced microglial activation models and glutamate-induced neuronal damage models. The data showed that CMS121 achieved up to 82% inhibition of microglial overactivation, significantly reduced the release of neuroinflammatory factors, and protected hippocampal neurons from oxidative death. Related experiments further verified that CMS121 improves neuronal survival rate and delays cognitive decline, providing strong experimental evidence for Alzheimer's disease and chronic neuroinflammation mechanism research and neuroprotective drug screening.

Case 4: Oxidative Stress Injury & Anti-Senescence Verification Research

Multiple cell senescence experiments adopted CMS121 Powder as the core intervention compound. By regulating the ACC1-AMPK signaling axis, CMS121 stably maintained intracellular GSH antioxidant levels, efficiently cleared excess ROS, and alleviated DNA and mitochondrial oxidative damage. Researchers confirmed that CMS121 can significantly delay cellular senescence and resist ischemia-reperfusion oxidative injury, which is widely used in cell anti-senescence mechanism research and antioxidant active compound efficacy verification.

Case 5: Lipid Metabolism Disorder & Metabolic Pathway Validation

In lipid metabolism research projects, CMS121 Powder was used for targeted ACC1 inhibition experiments to verify the regulatory relationship between ACC1 enzyme activity and endogenous lipid synthesis. Experimental data proved that CMS121 can effectively block abnormal lipid synthesis pathways, reduce intracellular lipid accumulation, and activate AMPK-mediated energy catabolism. This application case is widely referenced in metabolic disorder pathogenesis research, lipid-lowering pharmacological mechanism exploration and new metabolic drug target validation.

5.1 Core Pharmacological Activity Data (Verified)

Our high-purity CMS121 Powder possesses stable and accurate pharmacological activity with verified experimental data, which is critical for high-standard preclinical research and drug screening. As a selective ACC1 inhibitor, CMS121 delivers precise inhibitory efficacy with low cytotoxicity. The core activity parameters are listed below:

Primary Target IC50: ACC1 inhibitory IC50 ≈ 1.8 μM, showing potent targeted suppression on acetyl-CoA carboxylase 1

Microglial Inhibition Activity: Up to 82% inhibition rate against LPS-induced N9 microglial overactivation at optimal working concentration

Effective Working Concentration Range: 0.5 μM – 10 μM for in-vitro cell experiments; 10–30 mg/kg for in-vivo animal models

Cell Cytotoxicity: Negligible cytotoxicity within effective experimental concentration range, ensuring reliable and repeatable experimental results

Oral Bioavailability: Excellent oral absorption performance, suitable for oral administration animal intervention experiments, superior to pure cell-only inhibitors

5.2 ACC1 Target Protein Background

Acetyl-CoA Carboxylase 1 (ACC1) is a rate-limiting enzyme in fatty acid synthesis, widely distributed in mammalian liver, brain, kidney and adipose tissues. It plays a decisive role in regulating intracellular lipid metabolism, energy homeostasis, inflammatory response and neuronal metabolic balance. Abnormal overexpression of ACC1 is closely correlated with neurodegeneration, chronic inflammation, renal aging, obesity, insulin resistance and hepatic steatosis.

Selective inhibition of ACC1 can effectively block abnormal lipid synthesis, activate AMPK energy-sensing pathway, elevate intracellular acetyl-CoA and GSH levels, reduce ROS accumulation and inflammatory factor release. As a highly specific ACC1 tool compound, CMS121 is irreplaceable for exploring ACC1-mediated metabolic and immune regulatory mechanisms.

Compared with traditional classic ACC inhibitors (TOFA, Etomoxir, Soraphen A), CMS121 shows comprehensive performance advantages for preclinical multi-organ protection and long-term intervention research, making it the preferred compound for current high-end biomedical projects:

Higher Target Specificity: CMS121 selectively inhibits ACC1 with almost no off-target inhibition on ACC2 or other metabolic enzymes, avoiding non-specific experimental interference. Traditional inhibitors easily cause widespread metabolic suppression and data deviation.

Excellent Oral Bioavailability: Most early ACC inhibitors are only suitable for in-vitro cell experiments. CMS121 supports oral administration, perfectly adapting to long-term animal model intervention and in-vivo pharmacodynamic verification.

Multi-Organ Protective Activity: Beyond simple lipid regulation, CMS121 integrates neuroprotection, anti-inflammation, renal protection and anti-aging effects, meeting multi-dimensional research needs of complex disease models.

Lower Cytotoxicity & Higher Safety: Stable effective concentration window, no obvious toxic side effects in long-term intervention, suitable for aging animal models and chronic disease research.

Stable Batch Activity Consistency: Synthetic purification process is mature and controllable, solving the problem of unstable activity of natural or semi-synthetic inhibitor products.

7. Standard Laboratory Use Protocol (Professional Guidance)

To help global researchers obtain stable and repeatable experimental data, we provide standardized dissolution, dilution and storage operation guidelines for CMS121 Powder:

7.1 Stock Solution Preparation

CMS121 is easily soluble in DMSO, ethanol and methanol. For standard laboratory use, prepare 10 mM DMSO stock solution: weigh accurate CMS121 powder and dissolve in high-purity DMSO, shake gently until fully dissolved, no precipitation or turbidity.

7.2 Working Concentration Reference

Cell experiment: 0.5 μM – 10 μM (adjust according to different cell lines and intervention cycles) Animal experiment: 10–30 mg/kg/day oral administration, suitable for long-term metabolic and neuroprotection intervention

7.3 Usage & Operation Tips

Avoid repeated freeze-thaw cycles of stock solution; subpackage stock solution into small tubes for single use; keep away from light and moisture during operation; conduct compound intervention after cell synchronization to ensure uniform experimental conditions.

High-purity CMS121 Powder possesses excellent biosafety for laboratory preclinical research. Within the effective experimental concentration range, it shows extremely low cell cytotoxicity, no acute toxic reaction, no obvious organ damage and no abnormal animal death in long-term feeding experiments.

Different from toxic broad-spectrum metabolic inhibitors, CMS121 regulates physiological metabolism in a targeted and mild manner, with high biological tolerance. It is safe for cell culture intervention, short-term and long-term animal model experiments, and fully complies with international biomedical laboratory safety standards.

Other Nootropics Raw Material Also Available

Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

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