5-Amino-1-Methylquinolinium Iodide（NNMTi）Powder

5-Amino-1MQ (5-Amino-1-methylquinolinium) is an investigational compound that is being explored primarily for health issues related to metabolism, weight management, and muscle mass. Its mechanism of action primarily involves inhibition of creatine kinase and methyltransferase, which affects fat breakdown and energy metabolism. 5-Amino-1MQ works by inhibiting methyltransferase, reducing methylation in muscle cells, and partially blocking the function of creatine kinase, ultimately promoting lipolysis, the breakdown of body fat and the release of energy. This mechanism is thought to help reduce fat storage and promote the efficient use of energy. Some studies suggest that 5-Amino-1MQ may have potential in obesity management because it helps reduce fat accumulation by enhancing lipolysis.

5-Amino-1MQ Powder, chemical name 5-Amino-1-methylquinolinium iodide, is a well-documented small-molecule selective nicotinamide N-methyltransferase (NNMT) inhibitor, widely used in preclinical metabolic research, cell energy metabolism studies and biochemical mechanism exploration. Also known as NNMTi, this quinolonium iodide compound features excellent cell membrane permeability and high target selectivity, making it one of the most popular research reagents for investigating adipogenesis, NAD+ balance and cellular bioenergetics.

We are a professional manufacturer and exporter of high-grade 5-Amino-1MQ Powder. All products strictly follow international laboratory chemical standards, supported by full set of testing documents. We provide sample trial orders and bulk wholesale for universities, pharmaceutical R&D laboratories, biotech companies and chemical research institutes worldwide. Important Notice: This product is intended for scientific laboratory research only. Not for human consumption, clinical application or food additive use.

5-Amino-1MQ is a cationic small molecule inhibitor built on a 1-methylquinolinium aromatic skeleton. Its unique molecular structure enables specific binding to the active site of NNMT enzyme, with minimal off-target activity against other SAM-dependent methyltransferases.

In biochemical research models, elevated NNMT activity consumes intracellular nicotinamide, disturbs NAD+ circulation and promotes lipogenesis. By inhibiting NNMT activity, 5-Amino-1MQ helps researchers study the regulation of cellular NAD+ levels, energy expenditure and fat cell formation.

Our high-purity 5-Amino-1MQ powder adopts advanced purification and recrystallization technology:

Strictly control residual solvents, heavy metals and unknown impurities to avoid interference with experimental data

Uniform crystal particle size, stable dissolution performance, good repeatability for in vitro & in vivo tests

Stable chemical properties; low decomposition rate under standard storage conditions

Consistent batch-to-batch quality, eliminating experimental deviation caused by raw material fluctuation

Cellular Energy Metabolism Research Explore the regulation mechanism of the NAD+ salvage pathway, study how NNMT inhibition affects mitochondrial energy metabolism and redox balance.

Adipogenesis & Obesity Preclinical Research Investigate lipogenesis in adipocyte models, study the relationship between NNMT and fat accumulation, weight management related preclinical mechanism research.

Sarcopenia & Muscle Tissue Research Used in studies on myogenic differentiation, explore the influence of metabolic pathway changes on muscle cell maintenance and aging-related muscle loss.

Epigenetic & Methylation Pathway Research Analyze the SAM/SAH methylation balance inside cells, support research on epigenetic modification regulated by NNMT.

Pharmaceutical Lead Compound Screening Serve as a reference tool molecule for developing new metabolic regulatory small-molecule drug candidates.

Biochemical Enzyme Assay Development Standard inhibitor reagent for establishing NNMT enzyme activity screening models in high-throughput laboratory platforms.

✅ High Purity & Strict Quality Control

Every batch is tested by HPLC, LC-MS for identity confirmation. Purity ≥99.0%. We strictly control trace impurities to guarantee reliable, reproducible experimental results for academic and corporate labs.

✅ Complete Document Support

We can provide full documentation including: COA (Certificate of Analysis), HPLC chromatogram, NMR spectrum, MSDS/SDS, packing list, commercial invoice and other export documents, convenient for your customs clearance and laboratory filing.

✅ Flexible Order & Stable Inventory

Support small sample order (1g, 5g, 10g) for preliminary testing; accept bulk orders from 100g to kilograms. Sufficient spot inventory enables fast arrangement of shipment. We support customized packaging according to customer requirements.

✅ Global Professional Logistics

Small sample parcels shipped via DHL, FedEx, UPS, TNT (3–7 working days delivery). Bulk goods can choose air freight or sea freight. We are familiar with international chemical reagent export requirements, offer FOB, CIF, DDP trade terms and solve customs clearance consultation.

✅ Professional Technical Support

Our chemical team can answer your questions about product solubility, storage, experimental formulation and handling precautions. We offer long-term stable supply support for continuous research projects.

5. Packaging Options

Sample Package: 1g / 5g / 10g vacuum aluminum foil bag

Small Batch Package: 50g / 100g sealed plastic bottle

Bulk Package: 1kg / 5kg aluminum drum / chemical fiber drum with double-layer moisture-proof sealing

Customized packaging specifications are available upon request

6. Storage & Safety Notes

Keep container tightly sealed, avoid moisture, direct sunlight and high temperature environment

Long-term preservation: Store at -20°C, avoid repeated freeze-thaw cycles

Operate in well-ventilated laboratory fume hood; wear gloves, goggles and protective clothing

Avoid direct contact with skin, eyes and inhalation of dust

For Research Use Only. Not for human or veterinary therapeutic use.

High Purity ≥99% - HPLC tested, low impurities, no experimental interference

High Specificity - Selective NNMT inhibition, minimal off-target effects

Stable Batch Consistency - Strict GMP-level production control

Complete Documents - COA, HPLC, NMR, MSDS, Export documents available

Flexible Supply - Sample & bulk quantity available, fast global shipping

Professional Support - Lab usage guidance and technical support

Mechanism of Action – How 5-Amino-1MQ Works

5-Amino-1MQ functions as a potent, selective NNMT inhibitor with low off-target effects. NNMT is a key metabolic enzyme that regulates nicotinamide methylation, consumes cellular SAM resources, reduces NAD+ availability, and promotes lipid accumulation and metabolic dysfunction. By selectively suppressing NNMT enzymatic activity, 5-Amino-1MQ effectively rescues intracellular NAD+ levels, improves energy metabolism, reduces adipogenesis, and regulates inflammatory and epigenetic methylation pathways.

Wide Research Applications of 5-Amino-1MQ Powder (Detailed Scenarios)

5-Amino-1MQ is a core tool compound in modern life science research. Its high specificity and cell permeability make it widely used in metabolism research, aging biology, obesity models, muscle physiology, cancer metabolism, inflammation mechanism and new drug development. The detailed application scenarios are as follows:

1. Metabolic Disorder & Obesity Research

NNMT is highly overexpressed in obese adipose tissue and metabolic syndrome models. 5-Amino-1MQ powder is widely used to study fat cell differentiation, lipogenesis inhibition, fat browning, and energy expenditure regulation. Researchers use 5-Amino-1MQ to verify the relationship between NNMT overexpression and body fat accumulation, insulin resistance, and lipid metabolism disorders. It is one of the most critical reagents for obesity mechanism exploration and anti-obesity drug screening.

2. NAD+ Metabolism & Anti-Aging Research

As a key regulator of the NAD+ salvage pathway, NNMT directly affects cellular NAD+ concentration and sirtuin activity. 5-Amino-1MQ intervention can effectively restore NAD+ levels, delay cellular senescence, improve mitochondrial function and reduce oxidative stress. It is widely applied in aging mechanism research, cell senescence models, anti-aging compound evaluation, and longevity-related pathway exploration.

3. Muscle Atrophy & Sarcopenia Research

Multiple studies have confirmed that NNMT upregulation contributes to muscle loss and weakened muscle regeneration. 5-Amino-1MQ powder is commonly used in skeletal muscle cell experiments and animal models to study muscle fiber maintenance, myogenic differentiation, exercise metabolism, and age-related sarcopenia. It is an essential reagent for exploring new intervention targets for muscle atrophy and muscle metabolic improvement.

4. Cancer Metabolism & Tumor Microenvironment Research

NNMT is abnormally highly expressed in a variety of tumor cells, participating in tumor energy reprogramming, epigenetic modification, tumor proliferation and invasion. 5-Amino-1MQ is used for tumor metabolism mechanism research, tumor cell proliferation inhibition experiments, cancer stem cell regulation studies, and screening adjuvant anti-tumor small molecule pathways.

5. Epigenetic Methylation Research

NNMT competes for intracellular SAM methylation donors and affects global DNA and histone methylation status. 5-Amino-1MQ powder is widely used in epigenetics laboratories to study methylation balance, gene expression regulation, and epigenetic phenotypic changes caused by metabolic enzyme disorders.

6. Inflammation & Immune Metabolism Research

NNMT activity is closely related to macrophage activation, inflammatory factor release and immune cell metabolic reprogramming. 5-Amino-1MQ intervention can regulate immune cell metabolism and relieve chronic inflammatory responses. It is widely used in immunometabolism research, chronic inflammation models, and inflammatory mechanism verification.

7. New Drug Target Verification & Preclinical Compound Development

Pharmaceutical R&D companies use high-purity 5-Amino-1MQ as a standard positive inhibitor to verify NNMT-target drug efficacy, screen new metabolic regulatory drugs, and develop new treatment candidates for metabolic diseases, aging-related diseases and tumors.

8. Biochemical Enzyme Activity Assay & High-Throughput Screening

5-Amino-1MQ powder is used as a standard control inhibitor in laboratory NNMT enzyme activity detection kits, high-throughput compound screening platforms, and biochemical reaction system establishment, ensuring accurate and stable experimental data output.

As a high-precision organic synthesis intermediate, SANA CAS 42571-07-3 Powder is widely used in biochemical research, pharmaceutical intermediate development, fine chemical synthesis and other high-end fields, with diverse and high-value application scenarios:

Pharmaceutical Intermediate Synthesis: It is a key raw material for the synthesis of anti-inflammatory drugs, antioxidant preparations and targeted therapeutic small-molecule drugs. Its unique phenolic and nitrovinyl structure can be modified and derivatized to prepare multiple high-activity pharmaceutical intermediates, widely used in new drug R&D and generic drug synthesis.

Biochemical & Laboratory Research: Commonly used as a standard reagent and reaction substrate in biochemical experiments, cell activity research, and molecular biology experiments. It is also applied in the research of antioxidant mechanism and inflammatory response regulation, providing accurate experimental materials for university laboratories and scientific research institutions.

Fine Chemical Synthesis: Used for the preparation of high-end dyes, fluorescent probes, cosmetic active additives and polymer material modifiers. It can effectively improve the optical performance and chemical stability of downstream fine chemical products.

Organic Chemistry Derivatization Research: Applied in the research of nitrovinyl compound derivatization, salicylic acid functional modification, and multi-functional organic molecule synthesis, supporting innovative research in the field of organic chemistry.

Analytical Reagent Preparation: Used as a core raw material for customizing high-precision analytical reagents, detection reagents and experimental standard samples, meeting the high-precision detection needs of chemical analysis and environmental monitoring laboratories.

Other Nootropics Raw Material Also Available

Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

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