| Product Name | PTD-DBM (Protein Transduction Domain-Dishevelled Binding Motif) |
| CAS Number | 1609454-11-6 |
| Molecular Formula | C₁₂₄H₂₂₅N₆₁O₂₈S₂ |
| Molecular Weight | 3082.64 g/mol |
| Sequence structure | RRRRRRRRGGGGRKTGHQICKFRKC |
| Appearance | White to off-white / pale yellow solid powder |
| Purity | 98–99% (by HPLC) |
| Solubility | DMSO (primary) |
| Storage Conditions | Short-term (days–weeks): 0–4°C; Long-term (months): –20°C |
Products Description
What Is PTD-DBM?
PTD-DBM (Protein Transduction Domain-Dishevelled Binding Motif) is a synthetic peptide designed to promote scarless regenerative wound healing and hair regeneration.
TD-DBM functions as a competitive inhibitor targeting the CXXC5-DVL interaction.
PTD Domain Function: The 9-Arginine sequence (RRRRRRRR) is a Protein Transduction Domain, allowing the peptide to cross cell membranes effectively-a critical feature for intracellular target engagemen.
Applications Of PTD-DBM
These applications are speculative/hypothesized based on the peptide's molecular properties and require further validation. The strongest evidence remains in wound healing and hair research.
| Application Area | Development Stage | Key Evidence Source | Supplier Considerations |
|---|---|---|---|
| Wound Healing | Preclinical (mouse models) | Lee SH et al., J Exp Med 2015 -7 | Requires ≥98% purity, in vivo grade |
| Androgenetic Alopecia | Preclinical | Ryu YC et al., Cells 2023 -2 | Custom synthesis; 2-4 week lead time |
| Cosmetic Formulations | Commercial (topical products) | InfiniWell, Fullscript listings -3-9 | Cosmetic grade available |
| Emerging Applications | Hypothetical/Investigational | Review articles -6-8 | Research use only |
Benefits of PTD-DBM
1.Mechanism-Based Benefit for Hair.
PTD-DBM addresses hair loss at the molecular level by counteracting DHT-induced suppression of the Wnt pathway. Research demonstrates that DHT increases PGD2, which suppresses Wnt signaling via CXXC5-PTD-DBM overcomes this suppression by blocking CXXC5-Dvl interaction.
| Benefit | Description |
| Follicle Revitalization | Stimulates stem cells in hair follicles to regenerate and produce new follicles |
| Increased Hair Density | Helps hair appear visibly thicker and fuller in the area of application |
| Reduced Shedding | Inhibits hair follicle miniaturization associated with male pattern baldness |
| Anagen Phase Induction | Promotes transition into the growth phase of the hair cycle |
| Enhanced Blood Microcirculation | Improves delivery of nutrients and oxygen to follicles |
2.Cosmetic & Topical Formulation Benefits
2.1Cell-Penetrating Capability
The 9-arginine PTD domain (RRRRRRRR) enables the peptide to:
Efficiently cross cell membranes
Interact with cell membrane phospholipids for intracellular translocation
Facilitate delivery of other active ingredients into cells
2.2Suitable Formulation Types
PTD-DBM is suitable for incorporation into:
Facial serums for daily skincare
Lightweight emulsions and lotions
Eye contour creams and gels
Sheet masks and leave-on treatments
Ampoules and concentrated boosters
Night creams and restorative moisturizers
Comparative Benefit with other product
| Aspect | PTD-DBM Advantage | Comparison Point |
|---|---|---|
| vs. Minoxidil | Targets root Wnt pathway mechanism, not just vasodilation | Mechanism superiority |
| vs. Finasteride | No hormonal side effects; works through different pathway | Safety profile |
| vs. Standard Wound Care | Achieves scarless (regenerative) vs. scar-forming healing | Clinical outcome |
| vs. Corticosteroids | Promotes regeneration vs. suppressing inflammation | Therapeutic approach |
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CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q: What is the purity standard for research-grade PTD-DBM?
A: Research-grade PTD-DBM is typically available at ≥95% or ≥98% purity verified by HPLC. For in-vivo or preclinical studies, >98% is the industry standard to ensure bioactivity.
Q: What is the amino acid sequence of PTD-DBM?
A: The full sequence is: H-RRRRRRRRGGGGRKTGHQICKFRKC-OH -3-4-5.
It consists of a PTD domain (9 Arginines) facilitating cell penetration, a linker (GGGG), and the DBM motif.
Q: Is your PTD-DBM free of Trifluoroacetic Acid (TFA)? (Technical Intent)
A: Standard custom peptides often contain residual TFA from the purification process. For commercial cosmetic and research formulations, we offer a TFA-removed (or acetate counterion exchange) version of PTD-DBM to eliminate potential cytotoxicity and ensure formulation safety and stability.
Q: Can PTD-DBM be combined with other hair growth actives in topical formulations? (Commercial/Application Intent)
A: Yes. Research and market data show that PTD-DBM works synergistically with Wnt beta-catenin activators. It is highly effective when co-formulated with Valproic Acid (VPA) or Methyl Vanillate. It also pairs well with copper peptides (GHK-Cu) for comprehensive scalp rejuvenation.
Q: How should PTD-DBM be stored and transported?
A:Storage: Lyophilized powder must be stored at -20°C, desiccated and protected from light.
Transport: Suppliers generally ship with Blue Ice (cold packs) or at room temperature if delivery is within a few days, but long-term stability requires freezing.
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