product-1357-680

CRL-40,940, commonly known as Flmodafinil or Bisfluoromodafinil, is a synthetic nootropic and eugeroic compound. It is a structural analog of modafinil, modified by adding two fluorine atoms to its chemical structure. This modification enhances its potency and affinity for dopamine transporters, leading to stronger and longer-lasting effects compared to modafinil. It appears as a white crystalline powder with a purity of typically 98-99%. Its chemical formula is C₁₅H₁₃F₂NO₂S, and its CAS number is 90280-13-0.

CRL-40940 Flmodafinil

Product Name	CRL-40,940/Flmodafinil Powder
Chemical Formula	C15H13F2NO2S	Molecular Weight	309.33
CAS	90280-13-0	Batch Quantity	400kg
Batch No.	MLP-PPH-20231114	Manufacture Date	2025.11.14
Report Date	2025.11.17	Retest Date	2027.11.13

Testing Items		Specifications	Test Results
BP2010 /EP6	Appearance	crystalline powder	Conforms
	Melting point	About 205°C	206.4°C~206.7°C
	Identification	Meet the requirements	Conforms
	Appearance of solution	Clear, not more intense than Y7	Conforms
	PH	2.4~3.0	2.60
	Loss on drying	≤0.5%	0.04%
	Sulphated ash	≤0.1%	0.01%
	Heavy metals	≤20 ppm	<20 ppm
	Related substances	≤0.25%	Conforms
	Assay	99.0%~101.0%	99.8%
USP32	Identification	Meet the requirements	Conforms
	Loss on drying	≤0.5%	0.04%
	Residue on ignition	≤0.1%	0.01%
	Heavy metals	≤0.003%	<0.003%
	Residue solvent - Ethanol	≤0.5%	<0.04%
	Chloride	16.9%~17.6%	17.1%
	Assay	98.0%~102.0%	100.0%
Conclusion: The product complies with BP2010/USP32/EP6 standard

Flmodafinil exerts its effects by targeting neurotransmitter systems like dopamine and histamine, resulting in the following benefits:

Enhanced Wakefulness & Alertness

Acts as a powerful eugeroic to promote sustained wakefulness, reducing fatigue and drowsiness.

Requires a lower dosage threshold compared to modafinil for similar effects.

Cognitive Enhancement

Improves memory retention, learning capacity, and information processing speed.

Enhances focus, attention span, and mental clarity, making it popular for tasks requiring prolonged concentration.

Mood Regulation

Boosts mood and motivation by modulating dopamine levels.

Exhibits mild anti-aggressive and anxiolytic properties in preclinical studies.

Neurological Support

Shows potential in protecting neural function and may aid in managing neurodegenerative conditions like Alzheimer's disease (research in early stages).

Research & Clinical Trials

Investigated for treating sleep disorders such as narcolepsy, sleep apnea, and shift work sleep disorder.

Studied as an adjunct therapy for ADHD, Alzheimer's disease, and other cognitive impairments.

Nootropic Use

Used off-label by students, professionals, and athletes to enhance cognitive performance, especially during periods of sleep deprivation.

Pharmaceutical Development

Serves as a lead compound for developing novel wakefulness-promoting and neuroprotective drugs due to its improved pharmacokinetic profile.

Dosage & Safety: Flmodafinil is intended for short-term use. Typical doses range from 50-200mg daily. Side effects may include insomnia, headaches, or increased heart rate at higher doses.

Legal Status: It is not approved for medical use in most countries and is primarily available for research purposes.

Storage: Should be stored in a cool, dry, dark place with a shelf life of up to 24 months when properly preserved.

pharmacological differences between flmodafinil and modafinil

⚗️ Chemical Structural Differences

Flmodafinil is a difluoro derivative of Modafinil, with two fluorine atoms added to the para-position of the diphenylmethyl group in its molecular structure. This modification fundamentally alters the pharmacological properties of the drug:

Modafinil: Molecular formula C₁₅H₁₅NO₂S, molecular weight 273.35

Flmodafinil: Molecular formula C₁₅H₁₃F₂NO₂S, molecular weight 309.33

The high electronegativity of fluorine atoms enhances the binding affinity between the molecule and its target, while improving blood-brain barrier penetration efficiency

🎯 Mechanism of Action Differences

Both compounds increase synaptic dopamine levels by inhibiting the dopamine transporter (DAT), but differ in potency and selectivity:

Binding Affinity:

Flmodafinil has 3-4 times higher affinity for DAT than Modafinil (Ki values of 1.4μM vs 4.5μM respectively)

It shows weaker inhibition of norepinephrine transporter (NET) and serotonin transporter (SERT), reducing cardiovascular side effects

Pathway Specificity:

Modafinil also activates the orexin system and glutamatergic neurons

Flmodafinil acts almost exclusively through the dopamine pathway, with a more precise mechanism of action

📊 Pharmacokinetic Differences

Parameter	Modafinil	Flmodafinil
Bioavailability	~60% (with first-pass metabolism)	~90% (minimal first-pass metabolism)
Time to Peak Plasma Concentration	2-4 hours	1-2 hours
Half-Life	10-15 hours	15-20 hours
Metabolic Pathway	Primarily metabolized by CYP3A4	Primarily metabolized by CYP2C19
Active Metabolite	Modafinil acid (inactive)	Fluoromodafinil acid (weakly active)

💊 Pharmacodynamic Differences

Potency and Dosage:

Flmodafinil is 2-3 times more potent than Modafinil, with an effective dose range of 50-150mg/day

The conventional therapeutic dose of Modafinil is 200-400mg/day

Duration of Action:

Flmodafinil maintains wakefulness for 12-16 hours

Modafinil's effects last approximately 8-12 hours

Cognitive Enhancement:

Flmodafinil shows superior performance in tests of attention, working memory, and reaction speed

Modafinil provides more balanced mood improvement and anti-fatigue effects

⚠️ Safety and Tolerability Differences

Common Side Effects:

Modafinil: Headache, nausea, insomnia (incidence ~10-15%)

Flmodafinil: Headache, anxiety, insomnia (slightly higher incidence ~15-20%)

Drug Interactions:

Modafinil may induce CYP3A4, affecting metabolism of other drugs

Flmodafinil has minimal impact on CYP enzymes, resulting in lower risk of drug interactions

Abuse Potential:

Flmodafinil's stronger dopamine-releasing effect theoretically gives it slightly higher abuse potential than Modafinil

Neither compound is currently classified as a controlled substance, but rational use is advised

📈 Clinical Application Differences

Sleep Disorder Treatment:

Modafinil is FDA-approved for the treatment of narcolepsy, sleep apnea, and shift work sleep disorder

Flmodafinil is currently in clinical research stages and has not received approval for medical use

Cognitive Enhancement:

Flmodafinil demonstrates more significant cognitive improvement in healthy individuals, often used for academic and workplace performance enhancement

Modafinil is more commonly used for medical wakefulness maintenance

Neuropsychiatric Disorders:

Modafinil has been studied as an adjunct therapy for depression, ADHD, and Parkinson's disease

Research on Flmodafinil focuses primarily on cognitive impairment and neuroprotection

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Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

Package	1kg/bag ,25kg/bag;25kg/drum; customize as customer's equirements.
Transit	Fedex, TNT,DHL,EMS,and so on.
Shipping port	Shanghai/Tianjin/Dalian/Beijing/Xi'an
Lead Time	1-2 working days upon received the payment
For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea.

Q: 1. I want to know more details about the product, how can I contact you?

A: You can send us an email inquiry at any time. For more accurate quotes, I need the following information: product name, order quantity, receipt country, quality requirements, etc.

Q: 2. How do I know if your products are real or fake?

A: We will inspect every shipment. I can provide test reports including HPLC, MS and HNMR if you want. Please find a professional chemist to help you confirm the authenticity of the test report.
Of course, you can also purchase samples to take you around your trust.

Q: 3. How do you ensure the safety of the package I receive?

A: I want to receive the package safely, I first need to know your delivery address, do you have a preferred courier method, did you buy it from China?
Why do you want to know?
Because each country has different requirements for imported packages, especially chemical products, you need to know the basic information to provide you with the safest choice.
At present, we have professional customs clearance agents in EU countries, the United States, the United States, Canada, and Southeast Asia. We have professional customs clearance agents to ensure the safety of packages.

Q: 4. How to pay?

A: Our payment channels include bittoin, bank card, Western Union, Allegitudes, etc.
It is usually recommended that customers pay with Bitcoin, because the fee is low, the entry speed is fast, and the security is guaranteed.

Q: 5. How long does it take to receive the package?

A: This will vary according to the delivery method you choose. I will briefly introduce our commonly used special lines.
Usually European countries 10-15 days after sending you the tracking number.
In the United States and Canada, it usually takes 7-10 days.
Southeast Asian countries are 3-7 days.

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