|
Product Name |
Coluracetam |
|
Chemical Name |
N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxo-1-pyrrolidinyl)acetamide |
|
Synonyms |
MKC-231,BCI-540 |
|
Appearance |
White or off-white powder |
|
Purity |
99% by HPLC |
|
CAS Number |
135463-81-9 |
|
Molecular formula |
C19H23N3O3 |
|
Solubility |
Insoluble in Water; Soluble in DMSO (e.g., ≥60 mg/mL) ; |
Products Description
What is Coluracetam?
Coluracetam (development code: MKC-231, Coluracetam (development code: MKC-231, BCI-540) is a nootropic agent belonging to the racetam family. It was originally developed by Mitsubishi Tanabe Pharma in Japan primarily as a novel high-affinity choline uptake (HACU) enhancer, with the aim of investigating its potential to improve cognitive function, particularly its value in the treatment of cognitive disorders such as Alzheimer's disease.
Coluracetam is an experimental racetam compound with no pharmacological activity. It belongs to the second generation of nootropics and primarily acts on the high-affinity choline uptake (HACU) system in the brain. It is designed to enhance cholinergic neurotransmission, which may improve cognitive functions such as memory and learning ability.
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COA of Coluracetam
Application of Coluracetam
Coluracetam was originally developed by Mitsubishi Tanabe Pharma in Japan, primarily as a drug candidate for the treatment of Alzheimer's disease. In subsequent studies, its potential applications were further explored, covering a wide range of areas including neuropsychiatric disorders and ophthalmic diseases. The following provides a detailed description of its specific applications.
|
Application area |
Research stage |
Key research institutions |
|
Alzheimer disease |
Phase II clinical trial (terminated) |
Mitsubishi Tanabe Pharmaceutical |
|
Depression/Anxiety disorder |
Phase IIa clinical trial (Completed) |
BrainCells Inc. |
|
Schizophrenia |
Preclinical (animal experiments) |
Academic research |
|
Retinopathy/optic nerve injury |
early exploration |
Academic research |
Benefits of Coluracetam
| Specific benefits | Experimental model | Research Data |
| Improve spatial learning and memory | Inducing memory deficits in rats using the neurotoxin AF64A | Oral administration of 1–10 mg/kg of coluracetam significantly improved learning deficits in rats in the Morris water maze test, with superior efficacy compared to the conventional drug tacrine. |
| Improve working memory | Mice treated with AF64A (T-maze test) | After 11 days of chronic administration (0.3, 1.0, 3.0 mg/kg), the correct response rate in mice increased significantly from 61.1% (deficient group) to 86.1%, 85.0%, and 83.3%. |
| Reversing the decline in acetylcholine (ACh) levels | Mouse hippocampal tissue in which AF64A induces a decrease in ACh levels | After 12 days of chronic administration, the 0.3 mg/kg dose group restored ACh levels from 60.8% of normal to 84.4%; the 1.0 mg/kg dose group restored levels to 75.5%, demonstrating a significant effect. |
Packing & Shipping
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1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
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2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q1: What is the purity standard of your Coluracetam API, and how do you ensure batch consistency?
A: Our Coluracetam API maintains a purity of ≥99.0% (validated by HPLC). Each batch undergoes rigorous quality control, including NMR for structural verification and GC for residual solvent analysis. We provide a comprehensive Batch-Specific Certificate of Analysis (COA) to ensure that every shipment meets the exact chemical profile required for stable formulation.
Q2 :What are the solubility characteristics and formulation guidelines for Coluracetam?
A: Coluracetam is a fat-soluble Racetam derivative with low water solubility. It is highly soluble in organic solvents such as DMSO (≥60 mg/mL), Ethanol, and PEG400. For aqueous-based formulations, the use of surfactants like Tween 80 or co-solvents is recommended to ensure a homogeneous solution.
Q3:What is the recommended storage condition to maintain Coluracetam's shelf life?
A:Coluracetam API is sensitive to light and moisture. It should be stored in a cool, dry place (2-8°C or below 25°C), away from direct sunlight and heat. When stored in its original, factory-sealed vacuum-packed aluminum foil bags, the product has a stable shelf life of 24 to 36 months.
Q4:Can you provide samples for third-party lab verification (SGS/Eurofins)?
A: Absolutely. We support transparency and encourage third-party testing. We can provide 10g–50g pilot samples for your internal validation or for shipment to independent labs like SGS, Eurofins, or Colmar. This ensures the API matches your specific potency and safety requirements before bulk procurement.
Q5:What are your shipping protocols for 2026 global logistics and customs?
A: We utilize specialized chemical couriers (DHL/FedEx/TNT) and offer DDP (Delivered Duty Paid) services for specific regions to minimize customs delays. All API shipments are packed in double-layer PE bags inside a UN-rated fiber drum or tamper-evident aluminum bags, accompanied by all necessary export declarations to ensure 100% successful delivery.
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