| Product Name | Galantamine Hydrobromide |
| Molecular Weight | 368.27 g/mol |
| UNII Code | MJ4PTD2VVW |
| Appearance | White to almost white powder |
| Purity | 99% by HPLC |
| CAS Number | 1953-04-4 |
| Molecular formula | C₁₇H₂₁NO₃ • HBr |
| Solubility | Sparingly soluble in water |
| Storage | Powder: -20°C (stable for up to 3 years) |
Products Description
What is Galantamine Hydrobromide?
Galantamine hydrobromide is a reversible, competitive acetylcholinesterase inhibitor. Clinically, it is primarily used to treat dementia symptoms caused by mild to moderate Alzheimer's disease (AD). However, it does not cure the disease, and treatment must begin with a low dose while monitoring for side effects such as nausea and bradycardia.
Simply put, it is a medication that attempts to slow cognitive decline by regulating neurotransmitters in the brain.
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COA of Galantamine Hydrobromide
Application of Galantamine Hydrobromide
The applications of galantamine hydrobromide fall into two main categories: its primary and most common use is in the treatment of Alzheimer's disease; in addition, in certain countries and regions, it has other clinical applications based on its pharmacological effects.
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Applications |
Detailed Description |
Applications |
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Neurological diseases and injuries |
Improving memory disorders: It is used for benign memory disorders, as well as those caused by dementia and organic brain lesions |
Neurological diseases and injuries |
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Neuromuscular diseases: Used to treat myasthenia gravis, an autoimmune disorder that can cause muscle weakness |
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Sequelae of nerve injury: Used for sequelae of poliomyelitis, as well as sensory and motor disorders caused by neurological diseases or trauma -4. |
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Anesthesia and Surgery |
Antagonistic muscle relaxants: They are used at the end of surgery to antagonize the muscle relaxation effects of rotoxine chloride and its analogues (non-depolarizing muscle relaxants), helping patients restore spontaneous breathing and muscle function -4-7 |
Anesthesia and Surgery |
Benefits of Galantamine Hydrobromide
The primary benefit of galantamine hydrobromide is its use in treating mild to moderate Alzheimer's disease (AD)-related dementia, where it can improve patients' cognitive function, activities of daily living, and overall performance to some extent.
Improving Symptoms of Alzheimer's Disease
Clinical studies have confirmed that, compared to a placebo, galantamine provides statistically significant benefits for patients across multiple key dimensions. These benefits do not constitute a "cure," but rather serve to slow the progression of symptoms, maintain, or improve current functional status during treatment.
Dose-Response Relationship: Galantamine exhibits a clear dose-response relationship, meaning that higher doses yield more significant therapeutic effects. However, higher doses are also associated with a greater risk of side effects (such as nausea). Therefore, the standard clinical approach involves starting with a dose of 8 mg/day and gradually increasing the dose every 4 weeks to achieve the optimal balance between efficacy and tolerability.
Important Restrictions and Warnings (Non-Indications)
1. Not for use in mild cognitive impairment: Clinical trials have shown that the mortality rate in the galantamine group was significantly higher than in the placebo group (13 cases vs. 1 case) when treating patients with mild cognitive impairment; therefore, this drug should not be used to treat mild cognitive impairment.
2. Does Not Alter Disease Progression: Current evidence indicates that while galantamine may improve symptoms, it does not alter the underlying neurodegenerative process of Alzheimer's disease.
3. Ineffective for Specific Types of Dementia: There is no evidence that it is effective in treating other types of dementia or symptoms of memory impairment.
4. For research use only: As a biochemical reagent, galantamine is used in scientific research in fields such as neuroscience and apoptosis, but its use for human diagnosis or treatment is strictly prohibited.
Packing & Shipping
Products Description
CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q1: Which pharmacopeia standards does your Galantamine Hydrobromide API adhere to?
A: Our Galantamine Hydrobromide API is fully compliant with the latest editions of USP, EP, and BP. We provide a comprehensive Certificate of Analysis (COA) for every batch, ensuring the assay (HPLC) is consistently ≥99.0% and meets all specified limits for related substances and optical rotation.
Q2 :What is the origin of your API, and how do you control elemental impurities?
A: We offer both [Natural Extraction/Synthetic] Galantamine HBr. To ensure safety, we strictly follow ICH Q3D guidelines for elemental impurities. Using ICP-MS technology, we guarantee that heavy metals (Pb, As, Hg, Cd) are maintained well below 10ppm, meeting the highest safety thresholds for pharmaceutical applications.
Q3:Is the Particle Size Distribution (PSD) customizable for specific dosage forms?
A: Understanding that solubility affects bioavailability, we offer Micronized Galantamine Hydrobromide with customizable PSD. Our standard micronization achieves d90 < 10μm or 20μm, which is ideal for formulating high-uniformity tablets or extended-release capsules.
Q4:What are the storage requirements and long-term stability data?
A: Galantamine HBr is stable when stored in a cool, dry place (below 25°C or 2-8°C for long-term) and protected from light. Based on our ICH stability studies, the API has a retest period of 36 months when kept in its original, factory-sealed aluminum foil and fiber drum packaging.
Q5:Do you support third-party lab testing and audit requests?
A: We welcome transparency. We provide 10g–50g samples for verification by independent laboratories such as SGS, Eurofins, or Intertek. Furthermore, for high-volume contracts, we facilitate remote or on-site GMP audits to verify our quality management systems and production facilities.
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