| Product Name | N-Methyl-D-aspartic acid(NMDA) |
| Molecular Weight | 147.13 g/mol |
| UNII Code | MJ4PTD2VVW |
| Appearance | White crystalline powder |
| Purity | ≥98% (HPLC) |
| CAS Number | 6384-92-5 |
| Molecular formula | C₅H₉NO₄ |
| Solubility | Water solubility: approximately 25.9 mg/mL (21°C) |
Products Description
What Is N-Methyl-D-aspartic acid(NMDA)?
N-Methyl-D-aspartic acid (NMDA) is a synthetic amino acid derivative with the molecular formula C₅H₉NO₄. It is an analog of the natural neurotransmitter L-aspartate, distinguished by a methyl group attached to the nitrogen atom and a D- stereochemistry (mirror image of natural L-amino acids).
CAS Number: 6384-92-5
Molecular Weight: 147.13 g/mol
Physical state: White crystalline powder
NMDA is not an endogenous neurotransmitter per se, but is one of the most important tool drugs in neuroscience research. It selectively activates NMDA receptors in the central nervous system.
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Applications Of N-Methyl-D-aspartic acid(NMDA)
1.Electrophysiology: Bath application of NMDA (typically 10–200 μM together with 10 μM glycine) evokes inward currents in patch-clamp recordings.
2.Excitotoxicity models: Treating cultured neurons with 50–300 μM NMDA to study cell death mechanisms.
3.Pharmacology: Screening NMDA receptor antagonists (e.g., AP5, MK-801, memantine) by competing with NMDA binding.
Safety Note: NMDA is not a dietary supplement and has no approved human therapeutic use. It is strictly a research chemical that requires personal protective equipment (gloves, goggles) and should not be ingested or injected.
Benefits of N-Methyl-D-aspartic acid(NMDA)
1.The NMDA receptor, when bound by NMDA (or glutamate), exhibits three distinctive features:
| Feature | Description |
| Co-agonist requirement | Requires both NMDA/glutamate and glycine or D-serine to open. |
| Voltage-dependent Mg²⁺ block | At resting membrane potentials (~ -70 mV), a Mg²⁺ ion blocks the channel pore. Depolarization (e.g., via AMPA receptor activation) drives Mg²⁺ out. |
| High Ca²⁺ permeability | Once open, the channel allows significant Ca²⁺ influx, triggering intracellular signaling cascades. |
| Slow kinetics | Activation and deactivation occur over tens to hundreds of milliseconds – much slower than AMPA receptors. |
2.Learning & Memory: NMDA receptor-dependent Ca²⁺ entry is the essential trigger for Long-Term Potentiation (LTP) , the cellular basis of memory formation in the hippocampus.
3.Excitotoxicity: Excessive or prolonged NMDA receptor activation (e.g., during stroke or traumatic brain injury) causes Ca²⁺ overload, leading to mitochondrial damage and neuronal death. This is why NMDA itself is neurotoxic at high concentrations.
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Email:alice@xaheshun.com
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2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q1: What is the purity standard of your N-Methyl-D-aspartic acid (NMDA), and how is it verified?
A: Our NMDA is manufactured under strict quality control systems, guaranteeing a purity of 99% by HPLC. Every batch is accompanied by a comprehensive Certificate of Analysis (CoA), data to confirm its molecular identity and ensure no cross-contamination of L-isomers or heavy metals.
Q2 :What are the recommended storage conditions, and what is the shelf life of the product?
A: NMDA powder is relatively stable. We recommend storing it in a tightly sealed container and Under these recommended conditions, the shelf life is at least 24 months from the date of manufacture.
Q3:Are there any specific regulatory restrictions or export permits required for purchasing NMDA?
A: 6-Paradol is sensitive to light and heat. Our standardized powder is stable for 24 months when stored in a cool, dry place in its original sealed packaging. We use opaque, vacuum-sealed aluminum foil bags to prevent degradation during international shipping.
Q4: What is your minimum order quantity (MOQ) and lead time?
Our MOQ is 10g. Small quantities (up to 1kg) are in stock and ship within 2-3 days. Bulk orders (10kg+) typically require 2-4 weeks.
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