| Produsts Name | SS-31 |
| CAS No | 736992-21-5 |
| Purity | >99% |
| Appearance | White powder |
| storage | keep in a cool,dark location in a tightly sealed container or cylinder. |
| Shelf Life | 24 Months |
Products Description
What is Elamipretide?
Elamipretide (CAS 736992-21-5), also known as SS-31, is a synthetic tetrapeptide specifically designed to target mitochondrial inner membranes. It exhibits strong antioxidant activity and protects mitochondrial structure and function by reducing reactive oxygen species (ROS) production and maintaining ATP synthesis. Widely used in biomedical research, it is being studied for potential therapeutic applications in diseases associated with mitochondrial dysfunction, such as neurodegenerative disorders, cardiovascular diseases, and aging-related conditions.
Product COA
Certificate Of Analysis
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Product Name |
SS-31 |
CAS No. |
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Molecular Formula |
C32H49N9O5 |
Molecular Weight |
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Batch No. |
XR23110801-6 |
Date of Mfg |
Dec 27,2024 |
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Reference Standard |
Enterprise Standard |
Retest Date |
Dec 26,2027 |
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Storage |
In an airtight container,protected from light,at a temperature of 2℃ to 8℃. |
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TEST |
SPECIFICATION |
RESULT |
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Appearance |
White or almost white fluffy powder |
Conform |
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Solubility |
Soluble in water |
Conform |
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Water Content (Karl Fischer) |
≤ 8.0% |
2.20% |
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Sodium ion |
≤ 5.0% |
1.65% |
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Acetic Acid |
≤ 0. 1% |
0.07% |
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Trifluoroacetic Acid |
≤ 0.5% |
Not Detected |
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Peptide Purity (By HPLC) |
≥ 98.0% |
99.32% |
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Related Substance (By HPLC) |
Total Impurities(%) ≤ 2.0% |
0.68% |
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Largest Single Impurity(%) ≤ 1.0% |
0.31% |
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Bacterial Endotoxins |
≤10EU/mg |
Conform |
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Assay |
≥ 90.0% |
94.42% |
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Residual Solvents |
NMT 0.041% |
0.03% |
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Conclusion |
This batch of product conforms with enterprise standard and qualified. |
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Mechanism of Action
Targeting: Cationic residues interact with anionic cardiolipin, anchoring Elamipretide to the inner mitochondrial membrane.
ROS Scavenging: Directly neutralizes free radicals and inhibits lipid peroxidation, preventing mitochondrial DNA (mtDNA) damage.
Signaling Modulation: Downregulates pro-inflammatory cytokines (IL-1β, TNF-α) and upregulates anti-apoptotic proteins (Bcl-2), reducing cellular stress responses.
Development Status
Clinical Trials: Phase II studies for mitochondrial myopathy and heart failure have demonstrated favorable safety profiles, with ongoing research into neurodegenerative and ophthalmic applications.
Formulations: Currently administered via intravenous or subcutaneous injection; oral formulations are under preclinical development to enhance bioavailability.
Benefits of SS-31 Powder
Mitochondrial Protection
Directly targets the inner mitochondrial membrane, reduces reactive oxygen species (ROS) production, maintains membrane potential stability, and improves energy metabolism (e.g., enhances ATP synthesis).
Repairs mitochondrial cristae structure and enhances oxidative phosphorylation efficiency, especially in ischemic, aging, or diseased cells.
Neuroprotection
In Alzheimer's disease models, it improves cognitive function, reduces neuronal damage and inflammatory responses, and regulates the expression of synaptic-related proteins such as PSD-95.
Inhibits neuronal apoptosis and alleviates mitochondrial dysfunction caused by oxidative stress (e.g., damage to trabecular meshwork cells in glaucoma).
Anti-aging and Tissue Repair
Restores the osteogenic ability of aged bone marrow mesenchymal stem cells, reduces ROS levels by inhibiting NOS2 protein, and enhances cell viability.
Improves heart and muscle function in diseases such as heart failure and mitochondrial myopathy, with Phase II clinical trials underway.
Synergistic Effect in Drug Delivery
Often combined with carriers such as PLGA-PEG and DSPE-PEG as mitochondrial targeting ligands to enhance drug enrichment in diseased tissues (e.g., brain, myocardium) and reduce side effects.
Product Application
Biomedical Research: Used in studies on mitochondrial biology, oxidative stress, and disease mechanisms (e.g., Alzheimer's, Parkinson's, heart failure).
Preclinical Trials: Investigated for potential treatment of mitochondrial myopathies, age-related macular degeneration, and ischemic heart disease.
Laboratory Reagent: Applied in cell culture models to evaluate mitochondrial function and antioxidant efficacy.
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FAQ
Q1. What is the ordering process for the product?
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Q2. Do you have a minimum order quality?
Answer: Yes, our minimum order quality is one boxes, and of course you can contact us if you need less.
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Q6. How will you deliver the goods?
Answer: We have professional express forwarder, strong cooperate with DHL, UPS, USPS, FedEx, EMS, China Air Post.
Q7. When will we receive the goods?
Answer: We will send by DHL/FEDEX/UPS/USPS express, usually it takes about 7-15 days to reach you.
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