|
Product Name |
VIP Peptide |
|
Synonyms |
Vasoactive Intestinal Peptide Human, Pig, Rat;VIP |
|
Appearance |
White to off-white powder |
|
Sequence |
Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
|
Assay |
99% by HPLC |
|
Molecular Formula |
C147H238N44O42S |
|
CAS Number |
69856-17-3 |
|
Solubility |
H2O/DMSO |
|
Storage |
Cool dry place( Store at -20°C, away from the light) |
Products Description
What is VIP Peptide?
VIP Peptide is an extremely important multifunctional neuropeptide that plays a pivotal role as a signaling molecule in the human body. Unlike classical hormones primarily stored in the bloodstream, VIP functions more as a local messenger. Its effects extend far beyond the intestinal and vascular roles suggested by its name, as it is widely distributed throughout the nervous system and the entire body. Through the cAMP signaling pathway, VIP coordinates the functions of multiple systems including digestion, circulation, respiration, neurology, reproduction, and immunity, with its core actions promoting vasodilation, secretion, and anti-inflammation. In-depth research into its functions not only deepens our understanding of physiological integration in the human body but also provides novel approaches and targets for the diagnosis and treatment of various diseases.
Xi 'an Tongze can provide other peptide products, the catalog is as follows, welcome to consult!
|
Product Name |
CAS No. |
|
Goralatide |
127103-11-1/120081-14-3 |
|
ARA-290(Cibinetide) |
1208243-50-8 |
|
N-acetyl Semax Amidate |
2920938-90-3 |
|
N-AC-selank-amidate |
N/A |
|
Aviptadil Acetate |
40077-57-4 |
|
GLP-1(1-37) |
87805-34-3 |
|
GIP (huMan) |
100040-31-1 |
|
N-Acetyl-Semax |
N/A |
|
N-Acetyl Selank |
N/A |
|
S-Phenylacetyl Larazotide |
N/A |
|
Dermorphin |
77614-16-5 |
|
PEG-MGF |
N/A |
|
Met-enkephalin |
58569-55-4 |
|
Pramlintide Acetate |
196078-30-5 |
|
Dalargin |
81733-79-1 |
|
Abaloparatide |
247062-33-5 |
|
N-Acetyl Larazotide |
N/A |
|
Humanin |
330936-69-1 |
|
Adamax |
N/A |
COA of VIP Peptide
|
Product Name |
Vasoactive Intestinal Peptide(VIP) |
CAS Number |
96886-24-7 |
|
Manufacture Date |
2025/07/28 |
Expiration Date |
2027/07/27 |
|
Batch Number |
TZ20250728 |
Batch Quantity |
1KG |
|
Sequence |
Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
||
|
Item |
Specification |
Results |
|
Appearance |
White or off-white powder |
White powder |
|
Purity (By HPLC) |
≥98.0% |
99.10% |
|
Acetic acid Content (HPL.C) |
≤15.0% |
1.30% |
|
Water Content |
≤8.0% |
5.49% |
|
Related Solvents(GC)
|
Acetonitrile≤410ppm |
7ppm |
|
Methanol ≤3000ppm |
11ppm |
|
|
Methylene chloride≤600ppm |
Not detected |
|
|
lsopropyl ether ≤5000ppm |
Not detected |
|
|
N,N.Dimethylformamide≤880ppm |
Not detected |
|
|
Peptide Content |
Reported value |
92.12% |
|
Bacterial Endotoxins |
DCM≤10EU/mg |
<10EU/mg |
|
Conclusion |
the product conforms with enterprise standard and qualified |
|
|
Storage |
Keep in dark and cool dry place -20 to 8°C |
|
|
Shelf life |
2 Years When Stored properly |
|
Application of VIP Peptide
1.Established Clinical Application - Diagnosis and Localization of VIPomas
This represents the most classic and direct clinical application of VIP.
When patients present with severe watery diarrhea, hypokalemia, dehydration, and other symptoms, detecting significantly elevated plasma VIP levels serves as a key biochemical indicator for diagnosing VIPomas (a type of pancreatic neuroendocrine tumor). Normal plasma VIP concentrations are very low, whereas they can increase several-fold to dozens of times higher in VIPoma patients. Monitoring VIP levels post-surgery or during drug therapy can be used to assess treatment efficacy and detect recurrence.
2. New Drug Development and Potential Applications Based on the VIP Pathway (Primary Focus Areas)
Clinical research stages for rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, neurodegenerative diseases, and oncology.
Core physiological Benefits fully substantiated of VIP Peptide (robust data foundation)
These effects have been repeatedly validated in human physiology and basic medical research, constituting textbook-level knowledge.
1. Potent Vasodilatory Effects
Evidence: Consistently demonstrated in isolated vascular loop experiments, in vivo animal studies, and early human research. It induces muscle relaxation by activating the cAMP-PKA pathway in vascular smooth muscle cells. This is the direct reason for its designation as a "vasoactive" intestinal peptide.
2. Stimulation of Intestinal and Pancreatic Secretion
Evidence: VIP infusion significantly increases intestinal water, electrolyte, and pancreatic bicarbonate secretion. This constitutes the direct pathophysiological basis for severe watery diarrhea in VIPoma patients, inversely demonstrating the potency of this effect.
3. Non-adrenergic, Non-cholinergic Neurotransmitter Action
Evidence: Immunohistochemical and electrophysiological studies unequivocally demonstrate that VIP serves as the primary inhibitory neurotransmitter released by motor neurons in the digestive, respiratory, and reproductive tracts, mediating smooth muscle relaxation reflexes.
4. Immunomodulatory Effects
Evidence: Extensive in vitro cellular experiments (T cells, macrophages, dendritic cells) and animal inflammatory models (e.g., colitis, arthritis) confirm that VIP:
5. Inhibit production of pro-inflammatory factors (TNF-α, IL-6, IL-12).
1) Promote production of anti-inflammatory factors (IL-10).
2) Induce differentiation of regulatory T cells.
Supporting Data: Relevant research findings published in high-impact journals such as Nature Immunology and Immunity demonstrate clear mechanisms.
Note: Currently, endogenous VIP testing has a clearly defined and narrowly targeted patient population (individuals suspected of having VIPomas). As a therapeutic agent, the only patient group nearing clinical application with a clearly established indication is extremely preterm infants at risk of BPD. For other conditions, the applicability of VIP therapy remains in the future potential and research exploration phase. Any clinical application must be conducted by specialists under strict medical supervision after a thorough assessment of benefits versus risks.
Packing & Shipping
Customer Feedback
FAQ
Q: Can we offer Related products of VIP Peptide?
A: Yes, We can provide other peptides,welcome to consult.
Q: How do you treat quality complaint ?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q:Can customized packaging be carried out of VIP Peptide?
A:Of course, it can be repackaged. For instance, it is commonly used in vials or freeze-dried powder bottles for beauty purposes. We can provide them all.
Q:Is there a discount?
A:Of course, welcome to contact us. Price would be different based on different quantity. For bulk quantity, we will have discount for you.At the same time, we have a detailed list of discounted products and products with large inventory every quarter.
Q:Whether customized services can be provided
A:We offer ODM/OEM services and can manufacture according to specified formulations. We have our own designers who can design and customize private brands, packaging. Our customized service from the production of raw materials, design of brands/packaging, to the production of customized packaging, and then to packaging, mailing packages, one-stop production line, welcome to visit.
CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
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