| Product Name | SLU-PP-332 |
| CAS No. | 303760-60-3 |
| Purity | 99% |
| Appearance | White powder |
| Application | Weight loss, anti-aging |
| Package | Vials |
| Storage | Store in a closed container in a cool and dry place, below 5ºC. |
| Retest Date | 2 years |
Products Description
What is SLU-PP-332?
SLU-PP-332 is an experimental drug developed to mimic the effects of exercise by activating pathways in the body typically triggered by physical activity. It works through a mechanism involving ERR , which play a critical role in energy regulation. When administered in animal models, SLU-PP-332 showed potential benefits like increased energy expenditure, fat reduction.
Product COA
Certificate Of Analysis
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Product Name |
SLU-PP-332 |
CAS No. |
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Molecular Formula |
C63H83N17O14 |
Molecular Weight |
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Batch No. |
XR23110801-6 |
Date of Mfg |
Dec 27,2024 |
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Reference Standard |
Enterprise Standard |
Retest Date |
Dec 26,2027 |
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Storage |
In an airtight container,protected from light,at a temperature of 2℃ to 8℃. |
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TEST |
SPECIFICATION |
RESULT |
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Appearance |
White or almost white fluffy powder |
Conform |
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Solubility |
Soluble in water |
Conform |
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Water Content (Karl Fischer) |
≤ 8.0% |
2.20% |
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Sodium ion |
≤ 5.0% |
1.65% |
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Acetic Acid |
≤ 0. 1% |
0.07% |
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Trifluoroacetic Acid |
≤ 0.5% |
Not Detected |
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Peptide Purity (By HPLC) |
≥ 98.0% |
99.32% |
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Related Substance (By HPLC) |
Total Impurities(%) ≤ 2.0% |
0.68% |
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Largest Single Impurity(%) ≤ 1.0% |
0.31% |
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Bacterial Endotoxins |
≤10EU/mg |
Conform |
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Assay |
≥ 90.0% |
94.42% |
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Residual Solvents |
NMT 0.041% |
0.03% |
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Conclusion |
This batch of product conforms with enterprise standard and qualified. |
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SLU-PP-332 for Uses
SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function[1].
Benefits of SLU-PP-332 Powder
SLU-PP-332 improves a natural metabolic route, which typically happens in response to exercise; it amplifies energy expenditure and results in faster body fat metabolism. SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an ERR target gene [pyruvate dehydrogenase kinase 4 (Pdk4)], and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibres in skeletal muscle and improved exercise endurance in C57BL/6J mice. This drug works on a group of proteins throughout the body organs called ERRs that activate some of the most significant metabolic pathways in the body, including the cardiac cells and the brain tissue. The drug can potentially transform the future of fitness and can facilitate weight loss by stimulating the body's muscles during exercise. The mechanism of action of SLU-PP-332 is to activate ERRs, leading to increased energy expenditure, fatty acid oxidation, and decreased fat mass accumulation.
SLU-PP-332 (50 mg/kg, i.p., a single dose for 28 or 12 days) increases mitochondrial function and cellular respiration in a skeletal muscle cell line and induces an ERRα-specific acute aerobic exercise genetic program in mice[1].
SLU-PP-332 (50 mg/kg, i.p., twice per day for 28 days or 12 days) induces fatty acid metabolism, reduces fat mass and improves glucose metabolism in diet-induced obesity mouse models[3].
| Animal Model: | 8-10 male C57BL/6J mice[1] |
| Dosage: | 50 mg/kg |
| Administration: | i.p., a single dose for 28 or 12 days |
| Result: | Displayed a more oxidative muscle phenotype, increased the complex I (NDUFB8) and complex V (ATP5A) protein expression in the gastrocnemius muscle and cytochrome C, mitochondria content and oxidative type IIa muscle fibers lavels in mice. |
| Animal Model: | High fat diet-induced obesity mouse model[3] |
| Dosage: | 50 mg/kg |
| Administration: | i.p., twice per day for 28 days or 12 days |
| Result: | Did not alter brown adipose tissue mass, daily food intake and glucose metabolism, increased fatty acid oxidation (FAO) in normal in C57Bl/6 mice, but induced a progressive weight loss and decreased adipocytes size in high fat diet-induced obesity mouse models. |
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FAQ
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Answer: We will send by DHL/FEDEX/UPS/USPS express, usually it takes about 7-15 days to reach you.
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