| Product Name | 1-(1-Adamantylcarbonyl) proline |
| Purity | 98% |
| MF | C16H23NO3 |
| CAS | 35084-48-1 |
| Apperance | White powder |
| Shelf life | 2 years |
| Storage | Cool and dry place |
Products Description
1- (adamantane-1-carbonyl) -pyrr1- (1-Adamantylcarbonyl) Prolineolidine-2-carboxylic acid, also known as ACA, CAS number 35084-48-1, white or off-white powder, is a nitrogen-containing organic substance, used in supplement body.
Product COA
Certificate Of Analysis
|
Product Name |
1-(1-Adamantylcarbonyl) proline |
Cas. No. |
35084-48-1 |
|
Batch No. |
20230323 |
Packing |
25kg/drum |
|
Quantity |
3500KG |
Mfg. date |
Mar.28,2024 |
|
Expiry date |
Mar.27,2026 |
Analysis date |
Mar.28,2024 |
|
Test Method |
USP 43 |
Testing basis |
Pharmacopoeia Standards |
|
Testing items |
Specifications |
Test Results |
Conclusion |
|
Identification |
It should meet the requirements fo neomycin TLC identification test |
It meets the requirements fo neomyein TLC identification test |
Complies |
|
To the xylene layer add the P- bromoaniline TS,and a vivid pink- red color should develop upon standing |
It gives the positive reaction |
||
|
A solution should respond to ths tests for Sulfate |
It gives the positive reaction |
||
|
PH |
5.0-7.5 |
6.6 |
Complies |
|
Loss on Drying |
Not more than 8.0% |
5.5 |
Complies |
|
Assay |
It has a poteney equivalent to not less than 600ug of neomyci pei mg. (calculated on the dried basis) |
656μg/mg (calculated on the dried basis 618μg/mg(as is) |
complies |
|
Conclusion |
Tested according to USP43 fit cofnplies with the requirement. |
||
Pharmacological Efficacy of 1-(1-Adamantylcarbonyl) proline
1. Catalytic Applications in Organic Synthesis
Asymmetric Catalysis: Acts as a chiral organocatalyst in asymmetric reactions, such as:
Nucleophilic Addition Reactions: Catalyzes the asymmetric addition of aldehydes with alkyl azides, sulfonyl folates, and nitromethane, showing high activity towards alkyl azides.
Amination Reactions: Facilitates asymmetric amination processes, enabling the synthesis of chiral amines with stereoselectivity.
Aldol Reactions: Promotes the asymmetric aldol reaction between alcohols and aldehydes/ketones, yielding chiral aldol or hydroxyketone products.
2. Chiral Resolution and Synthetic Tool
Chiral Scaffold: Functions as a chiral resolving agent due to its inherent stereochemistry, aiding in the separation of enantiomers in organic synthesis.
Pharmaceutical Intermediate: Serves as a building block in the synthesis of complex organic molecules, particularly in pharmaceutical research where chiral purity is critical.
3. Physical and Chemical Properties Supporting Its Functions
Stability: Exhibits good stability under ambient conditions, allowing long-term storage without significant degradation.
Solubility: Shows low solubility in water but high solubility in organic solvents, making it suitable for organic reaction systems.
Structural Features: The adamantyl group enhances lipophilicity and steric hindrance, contributing to its catalytic selectivity, while the proline moiety provides the chiral center essential for asymmetric induction.
4. Limited Biomedical Efficacy
No proven therapeutic effects or biological activities (e.g., cognitive enhancement, memory improvement) are supported by peer-reviewed literature. Claims of neurological benefits in some commercial sources lack scientific validation.
Application of 1-(1-Adamantylcarbonyl) proline
Pharmacological Research: May act as a protease inhibitor, receptor modulator, or enzyme substrate due to the proline scaffold and adamantyl group.
Biomedical Studies: Could serve as a tool compound to investigate proline metabolism or protein-ligand interactions, though no specific biological activity has been documented.
Key Advantages
Rapid Onset & Short Duration: Mydriasis peaks within 20–30 minutes, with cycloplegia lasting 2–6 hours and residual dilation resolving within ~7 hours. This minimizes patient discomfort compared to longer-acting agents like atropine.
Good Ocular Penetration: Low dissociation constant enhances intraocular permeability, ensuring effective action at the iris and ciliary muscle.
Precautions
Contraindications: Angle-closure glaucoma (risk of acute intraocular pressure elevation) and hypersensitivity to anticholinergics.
Adverse Effects: Transient stinging, blurred vision, photophobia, and rarely, systemic effects (dry mouth, flushing) in pediatric patients.
FAQ
Q: What's your MOQ ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount ?
A: Yes, for larger quantity, we always support with better price.
Q: How to confirm the Product Quality before placing orders ?
A: You can get free samples for some proucts, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q: How to start orders or make payments ?
A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How do you treat quality complaint ?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we
will send you free goods for replacement or refund your loss.
Hot Tags: 1-(1-adamantylcarbonyl) proline, China 1-(1-adamantylcarbonyl) proline manufacturers, suppliers, factory, Larazotide for Celiac Disease, Dihydroberberine for Metabolic Support, Yohimbine Hydrochloride for Weight Loss, Povidone Iodine for Skin Protection, ALA Powder for Skin Aging, Pramoxine HCl for Skin Irritation
