Tesofensine is a central nervous system drug derived from structural optimization of Piribedil, a therapeutic drug for Parkinson's disease, aims to enhance the regulatory effects of neurotransmitters. Its structure core is tetrahydroisoquinoline ring (3,4-dihydroisoquinoline), which contains a chiral center (1-position carbon), and the R-isomer is the active form, thus determining its pharmacological effect.
It is mainly produced through chemical synthesis, through complex chiral synthesis, and uses 3,4-dichlorobenzoic acid or tetrahydroisoquinoline as the starting material to produce target molecules through alkylation, reduction and amination, etc.
 

1.It is mainly used in medicine to treat obesity. The common form is oral tablets or capsules once a day, and the dosage needs to be followed by the doctor's advice. At the same time, blood pressure and heart rate should be checked at all times during the use.
Suitable for obese patients with body mass index (BMI) ≥27 kg/m² and metabolic syndrome. If you lose weight through diet and exercise intervention, but the effect is not obvious, you can also take tesofencin capsules or tablets to improve your symptoms.

Tesofensine (formerly known as NS-2330) is a novel triple monoamine reuptake inhibitor (TRI)

Therefore, its effective impact on weight loss has attracted great attention.

Clinical trials demonstrated exceptional weight loss results. A phase II trial showed an average weight loss of ~12.8 kg (28.2 lbs) over 24 weeks at a 0.5 mg/day dose, significantly outperforming the placebo. This has made it a highly sought-after compound in the bodybuilding, biohacking, and weight loss communities despite its experimental status.

It inhibits the reabsorption of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) by neurons, and increases the concentration of monoamine neurotransmitters in the synaptic cleft. Triple monoamine reuptake inhibition achieves the effect mechanism through the following three targets.

1. The norepinephrine (NE) transporter adjusts the norepinephrine concentration in the synaptic cleft by blocking the reabsorption of thyrene NE by neurons, thereby activating the sympathetic nervous system and promoting thermal production and fat decomposition.
2. Dopamine (DA) transporters, by blocking dopamine reabsorption, increase the dopamine concentration in the nucleus accumbens, hypothalamus and other areas, can achieve the appetite suppression center and reduce the food reward effect.
3. Serotonin (5-HT) transporter, by blocking 5-HT reabsorption, increases the 5-HT concentration of the hypothalamus, thereby increasing your sense of fullness and reducing your urge to eat.

If you are an obese patient, you need to go through three stages, short-term, medium-term and long-term when taking tesofencin. In the short term, within 24 hours, it will increase your fullness and reduce your appetite. The medium term requires 4-12 weeks, and the weight will be reduced, and the average weight loss will be 0.4-0.5kg per week, and the body fat will also decrease, thereby indirectly improving insulin sensitivity. It takes about 24-28 weeks in the long run, and the weight will drop significantly. You can lose weight to 10.6kg on average, reduce fat mass by 75%, and reduce triglycerides. For obese patients, weight loss has obvious effects.

1.Packaging:25kg/drum
(25kg net weight,28kg gross weight; Packed in a cardboard-drum with two plastic bags inside; Drum Size: 510mm high, 350mm diameter)
(1kg/Bag net weight, 1.2kg gross weight, packed in an aluminum foil bag; Outer: paper carton; Inner: double-layer PE) OR as per your request.
2.Delivery time: 2~3 days after payment.
3.Storage: Stored in a cool & dry well closed container, keep away from moisture and strong light,high temperature.
4.Shelf life: Two years when properly stored.
5.Delivery: By UPS/DHL/TNT/EMS or by Air/ Sea as per Qty or as your requirement.
 

It is Active Pharmaceutical Ingredient,USP grade.Tesofensine, a triple monoamine reuptake inhibitor, aids in weight loss by suppressing appetite, increasing energy metabolism, and enhancing fat burning.

 

High purity ≥99.0%by HPLC

Moq is 1 gram,we have stock on hand

24 hours online service

We can offer OEM/ODM service

We can provide OEM/ODM customization services, for Tesofensine Powder we can customize capsules. Production according to your formula requirements and custom packaging design.

1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106

Online instant messaging

2.Contact Information：
Name：Alice

Telephone :+8618509260106
Email:alice@xaheshun.com

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