Capsaicin, also known as capsaicin or capsaicin alkaloid, namely trans-8-methyl-N-vanillyl-6-nonenoamide, is the active component of the red pepper, a plant of the Capsaicaceae genus.It is irritating to mammals, including humans, and can cause a burning sensation in the mouth.

Xi'an Tongze can provide two specifications of capsaicin. One kind Natural, which is extracted from the fruit of cayenne pepper. And synthetic, which is produced in a laboratory.

Capsaicin, as a natural extract, conforms to the trend of clean labels and can replace chemically synthesized capsaicin to synthesize chili oil resin

1.Used in the field of Functional body and hair products

Promoting metabolism through the thermogenic effect can be used in weight loss products. Capsaicin is added to some slimming creams.

Stimulating the microcirculation of the scalp can also be used in skin care products and may help improve hair loss, but more evidence is needed for this.

2. Used the field of Food Additive

1)Basic seasoning

Capsaicin, as a natural pungent component, can endow food with a rich and layered spiciness. Capsaicin is used in chili sauce, hot pot base, spicy snacks (such as potato chips and bean curd), and pickled foods (such as kimchi). When consuming these products, the capsaicin has to go through an extraction process, and the bioavailability of capsaicin is not high. Therefore, extracting and separating capsaicin from chili peppers as an additive in the food processing is conducive to the control of spiciness and the full absorption and utilization of capsaicin.

2)Food preservation and anti-corrosion

Capsaicin has inhibitory effects on Gram-positive bacteria (such as Staphylococcus aureus) and some fungi, and can extend the shelf life of meat products and condiments. At the same time, it can be compounded with vinegar, salt or other natural preservatives to enhance the preservative effect.

3. Used in the field of Health care product

Activate the TRPV1 receptor, stimulate the sympathetic nerve, promote the secretion of adrenaline, and increase the basal metabolic rate and fat breakdown. It is often used in meal replacement powders/tablets or sports supplements, when compounded with dietary fiber and CLA (conjugated linoleic acid), to enhance satiety and fat-burning effects. It can also be added to L-carnitine and caffeine formulas to enhance energy expenditure during exercise.

By depleting substance P to inhibit pain transmission, it alleviates osteoarthritis and muscle soreness after exercise. When combined with curcumin and Omega-3, it works synergistically to reduce inflammation and is used in joint health care capsules.

4.Used In the field of Agriculture and Environmental Protection

It can be used as a natural insecticide and is suitable for organic agriculture. It has a repellent effect on pests such as aphids and mites. It can also be used as an animal repellent to prevent rodents, deer and other animals from damaging crops or gnawing on cables.

The efficacy of capsaicin is mainly based on its interaction with the human TRPV1 receptor and biological activity, covering multiple effects such as analgesia, metabolic regulation, anti-inflammation, and antioxidation. For more details, please refer to the following

1.Analgesia and anti-inflammation

Capsaicin binds to the TRPV1 receptor at the pain nerve endings, initially causing a burning sensation, and then leading to the depletion of substance P (a pain signal transmitter), blocking the transmission of pain. Inhibit the NF-κB pathway and reduce the release of pro-inflammatory factors (such as IL-6, TNF-α). It is often manifested in the relief of arthritis and postherpetic neuralgia

2.Promote metabolism

Activate brown adipose tissue (BAT), increase energy expenditure, and raise the basal metabolic rate by approximately 4-5%. It is recommended to consume 6-10mg of capsaicin daily.

Promote fat breakdown through the adrenergic pathway and reduce visceral fat accumulation

3.Improve cardiovascular health

Stimulate endothelial cells to release nitric oxide (NO), dilate blood vessels and lower blood pressure. Inhibit the synthesis of thromboxane A2 and reduce the risk of thrombosis. Lipid regulation, promoting LDL cholesterol metabolism, and increasing HDL levels.

4.Antioxidant and anti-aging

It can eliminate free radicals and directly neutralize reactive oxygen species.

Up-regulate the expression of antioxidant enzymes SOD and glutathione, and reduce mitochondrial damage caused by oxidative stress. It is often manifested in the fact that topical preparations reduce ultraviolet damage and delay skin photoaging. Reduce oxidative damage caused by chronic inflammatory disease diabetes.

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