What is hexapeptide 9?

Hexapeptide-9 is composed of 6 amino acids and the sequence is acetyl-glutamate-glutamate-methionine-glutamine-arginine-arginine-amide (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂). It is not naturally occurring peptide and is prepared completely by chemical synthesis.

It is easily soluble in water and cosmetic solvents such as glycerin and propylene glycol. Stable in pH 4-7 formulations to avoid strong acid/alkali environments. No irritation to the skin or is not sensitized. It is often combined with other anti-aging components (such as palmitoyl tripeptide-5, hyaluronic acid) to enhance its effectiveness.

Hexapetide-9 (Hexapetide-9/Argireline) is mainly used to resist wrinkles and improve wrinkles in skin care. By simulating the SNAP-25 protein fragment, the formation of the SNARE complex is competitively blocked, while reducing the release of acetylcholine, thereby sootheing excessive contraction of facial muscles, achieving the effect of delaying wrinkle formation and deepening. It is specifically reflected in the following scenarios.

1. Improve the periophthalmic area

To improve the crow's feet in the corners of the eye and fine lines in the lower eyelid, it requires continuous use for 2-4 weeks, and the dynamic streak reduction rate is about 30%.

For skin care products that have used hexapeptide-9, when you laugh or squint, the folds at the corners of your eyes will become lighter and the number of lines will decrease.

When applying makeup, the smoothness of the skin around the eyes will increase under static conditions, and the powder trap will be reduced, making the makeup more appropriate.

2. Between forehead and eyebrows

Improve the forehead raising and horizontal lines, as well as the vertical lines and Sichuan characters between the eyebrows. Especially in medical beauty, using hexapeptide-9 can avoid stiff expressions caused by injection of botulinum to maintain a natural expression.

You have been using hexapeptide-9 skin care products for a long time. When you frown or raise your eyebrows, the tightness of the forehead muscles will decrease and the depth of the lines will become lighter.

3. Assist in improving nasolabial folds

By inhibiting frequent contraction of the nose wing to the corners of the mouth, the upper part of the nasolabial folds on both sides of the nasolabial wings are delayed. At this time, combined with palmitoyl pentapeptide-4, it can enhance the support of the dermis, so that the collagen on both sides of the nose is more abundant and without depression. Makes you look younger and your skin tighter.

4. Improve neck fine lines

By reducing muscle pulling when bowing and turning, this can prevent the formation of crease-type wrinkles. This improves the neckline pattern or the chest fine lines.

It is necessary to use it in combination with hyaluronic acid and panthenol containing moisturizing ingredients. In order to enhance the hydration of the skin, it helps to improve the generation of dry fine lines.

1. Only improve dynamic streaks, which are ineffective against static streaks. hexapeptide 9 need to be combined with palmitoyl tripeptide-5 to stimulate collagen regeneration.

2. The transdermal rate is low, and the bioavailability may be insufficient. Due to the large molecular weight, the absorption rate is low. You can use lecithin or select liposome wrapping technology products such as liposome raw materials to improve bioavailability.

3. The cost is high, and it is necessary to choose high concentrations to be effective. The unit price is high, and it can be effective for long-term use.

4. Avoid using neuromuscular diseases and sensitive muscle intolerance, which may interfere with nerve signals, especially those with myasthenia gravis and Parkinson's.

1.Blanes-Mira, C. et al. (2002). A synthetic hexapeptide (Argireline) with anti-wrinkle activity.
International Journal of Cosmetic Science, 24(5), 303–310.

2.Wang, Y. et al. (2014). Comparison of botulinum neurotoxin and peptide inhibitors.
Journal of Pharmacological Sciences, 125(1), 17–24.

3.Lombardi Borgia, S. et al. (2005). Liposomal encapsulation of peptides for skin delivery.
European Journal of Pharmaceutics and Biopharmaceutics, 60(3), 479–487.

4.Zhang, L. & Falla, T.J. (2010). Cosmeceuticals and peptides.
Clinics in Dermatology, 28(5), 505–513.