What is L-alanyl L-glutamine used for?

L-alanyl L-glutamine is an artificially synthesized dipeptide that does not have a direct source in nature. -Molecules made by bonding two separate amino acids: L-alanine and L-glutamine.

Why combine them together? Although L-glutamine itself is a very beneficial amino acid, it is well known that it is unstable in liquid form and can easily break down upon exposure to heat or stomach acid. By immobilizing it on L-alanine, we created a stable, highly parenteral nutritional supplement. This means your body can absorb and use it more effectively than standard glutamine powder.

Its appearance is a white crystalline powder and is odorless. It is easily soluble in water (about >500 g/L at 25℃), and is almost insoluble in ethanol. The solubility is significantly higher than glutamine, which is suitable for high concentration infusion. Avoid degradation of free glutamine during sterilization.

Think of it as a protected delivery system that ensures that the precious glutamine reaches exactly where it is needed in the body.

Now, let's explore the core reasons people use this powerful supplement.

1. Intestinal health and intestinal integrity

It can be said that this is the most prominent and most carefully studied purpose of L-alanyl L-glutamine. Your intestinal wall is the body's first line of defense against toxins and pathogens. The cells that make up the lining use glutamine as their primary fuel source.

Its working principle: L-alanyl L-glutamine provides an easy-to-access fuel supply to intestinal cells. Intestinal cells directly use glutamine to provide energy (70% of the required energy) to maintain villous structural integrity. This helps maintain a strong and tight intestinal wall. Uneliminated particles and toxins can be leaked into the bloodstream, causing inflammation, bloating and other problems.

Suitable for people suffering from digestive discomfort, irritable bowel syndrome (IBS), food-sensitive, or those who wish to enhance their gut after an antibiotic course have drug resistance.

2. Improve athletic performance and recovery

If you are a fitness enthusiast, maybe glutamine is your staple food. However, L-alanyl L-glutamine takes these benefits to the next level.

Often intense physical exercise can drain glutamine levels in muscle and blood. This inclination is associated with muscle soreness, fatigue and weak immune system after exercise. By quickly supplementing glutamine storage, blood sugar can be maintained and ammonia accumulation can be reduced, thus delaying fatigue.

Support Hydration: Helps pull water and electrolytes into muscle cells, thereby promoting optimal function and recovery.

Enhance immune function: Provide energy to lymphocytes and macrophages, and improve anti-infection ability.

3. Antioxidant and detoxification

L-alanyl L-glutamine is hydrolyzed into glutamine and alanine in vivo, and glutamine is further converted into glutamate, which is a key precursor for the synthesis of glutathione (GSH). It can directly eliminate free radicals, reduce vitamin C/E and thioredoxin, and form an antioxidant circulation network. In order to prevent lipid peroxidation, maintain mitochondrial membrane stability, and achieve the effect of protecting cell structure.

Glutamine releases ammonia under the action of glutaminease, and ammonia is converted into urea through the urea cycle and excreted from the body. Alanine participates in the glucose-alanine cycle, transporting the amino groups in the muscles to the liver to synthesize urea, further enhancing the detoxification efficiency. So L-alanyl L-glutamine in the detoxification process of ammonia and reduces the burden on the liver and kidneys.

It is suitable for people who drink alcohol for a long time and stay in heavy metal areas for a long time. They can take L-alanyl L-glutamine related products, which need to be carried out under the guidance of a doctor.

4.Clinical treatment support

Suitable for adjuvant tumor radiotherapy, metabolic support in intensive care patients, and digestive fistula/postoperative healing.

For adjuvant tumor radiotherapy, glutamine can be provided to repair mucosal DNA and upregulate heat shock proteins to protect epithelial cells. By inhibiting the NF-κB pathway, radioactive inflammatory factor storm is alleviated. Because chemoradiotherapy damages mucosal cells that divide rapidly, this action can repair the mucosal, which has an auxiliary effect on the treatment process.

For digestive fistula/postoperative healing, the rapamycin target protein pathway is activated by promoting intestinal epithelial cell migration. It can increase intestinal mucin secretion to strengthen the physical barrier. Through this effect, anastomotic fistula can be performed after gastrointestinal surgery, which can reduce the chance of abdominal infection caused by leakage in the intestine. Therefore, after gastrointestinal surgery, the wound can be healed faster.

L-alanyl L-glutamine is usually found in the following ways:

Powder Form: Easily blend into water, juice or post-workout shake. It has a neutral to a little sweet taste.

Capsules/Tablets: A convenient choice for travelers.

Ready-to-shelf supplements: usually included in advanced formulas for gut health or recovery.

Typical doses for general health range from 2-5 grams per day, while athletes may use 5-10 grams after exercise. As always, it is best to consult a healthcare professional to determine the correct dose that suits your specific needs.

Xi'an Tongze Bio can provide OEM/ODM customization. We have our own formula, or we can customize the formula and have professional laboratory personnel to conduct the test. The following product forms are products we designed ourselves (for reference only). Welcome to consult.

1.Common side effects

Intestinal discomfort such as abdominal discomfort, diarrhea, nausea, etc.

Metabolic alkalosis, such as hypokalemia

Recommendation: Dosage adjustment is required and taken with the meal, consult a doctor

2.Severe side effects

If you experience headaches, tremors, worsening hepatic encephalopathy, and risk of kidney damage, it is best not to use such products

3.Special group of people

Pregnant women, children (<12 years old) and cancer patients need to follow the doctor's advice and avoid intravenous injections.

Note: Under standard doses, the overall safety of L-alanyl L-glutamine

is good (severe adverse reaction rate <0.1%), but medical uses need to be carried out under clinical monitoring to avoid patients' overdose.

1.Effect of L-alanyl-L-glutamine on ICU mortality and infectious complications in severe sepsis: REDOXS trial
Journal: Crit Care Med. 2011;39(6):1263-8.

2.Intestinal permeability and systemic infections in critical illness: Effect of glutamine
Journal: Crit Care Med. 2005;33(5):1125-35.

3.Glutamine and glutathione in ammonia detoxification
Journal: Metab Brain Dis. 2018;33(1):21-30.

4.Nonnutritive effects of glutamine
Journal: J Nutr. 2007;137(10):259S-263S.

5.Glutamine metabolism in lymphocytes
Journal: Biochem J. 2005;386(Pt 1):1-11.