What is Tetrahydrocurcumin used for？

Tetrahydrocurcumin is a Curcumin found in Curcuma longa and is produced by the reduction of curcumin.

Tetrahydrocurcumin is a white crystalline powder that is soluble in organic solvents such as methanol, ethanol, and DMSO.Such a solubility property enables it to play an important role in chemical reactions.

Tetrahydrocurcumin, as a natural source of cosmetic whitening raw material, is mostly used in middle and high-end whitening cosmetics, tetrahydrocurcumin liposomes after liposome.

And unlike yellow curcumin,tetrahydrocurcumin has a white appearznce and is widely used in various skin care products such as whitening,freckle removal and anti-oxidation.

Tetrahydrocurcumin (THC) is one of the main metabolites of curcumin. Compared with curcumin, its stability and bioavailability may be higher,Its main uses are as follows.

1.Used for Cosmetic raw materials

1)Tetrahydrocurcumin can inhibit tyrosinase activity and reduce melanin production, and is often used in whitening essences and face creams.

2)Tetrahydrocurcumin can neutralize free radicals, reduce skin photodamage induced by ultraviolet (UV) rays, and delay the formation of wrinkles. It is added to high-end brand sunscreens.

3)Tetrahydrocurcumin can promote the synthesis of collagen, repair sensitive or damaged skin, and is commonly found in repair products such as essences and masks.

2.Used for health care product

Tetrahydrocurcumin (THC) is often used as a functional component in dietary supplements due to its high bioavailability and various biological activities, such as antioxidation, liver protection, and blood sugar regulation. For more details, please refer to the following explanation.

1)Strong antioxidant and anti-aging effects

It has antioxidant effects, eliminates free radicals, activates antioxidant enzymes such as SOD and glutathione peroxidase, and prevents oxidative damage caused by chronic diseases such as cardiovascular diseases and diabetes. Supplements used to delay cellular aging and assist in anti-aging.

2)Protect liver health

Reduce the toxicity of acetaldehyde produced by alcohol metabolism and inhibit lipid peroxidation in hepatocytes. Reduce the levels of liver enzymes (ALT, AST), inhibit the activation of hepatic stellate cells, and decrease liver fibrosis. Common products include alcohol-relieving and liver-protecting tablets.

3)Regulate blood sugar

Activate the AMPK pathway and enhance glucose uptake. Inhibit α -glucosidase and slow down the decomposition and absorption of carbohydrates. It can prevent complications of diabetes.

4)Support cardiovascular health

Reduce the oxidation of low-density lipoprotein (LDL) and inhibit the formation of atherosclerotic plaques. Improve vascular endothelial function and regulate the level of nitric oxide (NO). It can regulate blood lipids, lower triglycerides and total cholesterol, and also assist in controlling hypertension and preventing thrombosis.

5)Improve cognition and protect nerves

Reduce β -amyloid protein deposition and inhibit excessive phosphorylation of tau protein. Protecting neurons from oxidative stress and inflammatory damage can help prevent neurodegenerative diseases such as Alzheimer's and Parkinson's, and improve memory decline.

6)Regulate immunity and have anti-inflammatory effects

Inhibit the NF-κB pathway and reduce the release of pro-inflammatory factors. Regulate immune balance and alleviate chronic inflammation. It is often applied to relieve the symptoms of inflammatory diseases such as arthritis and enteritis.

7)Protect the muscles

It can alleviate oxidative stress and muscle inflammation after exercise, accelerate lactic acid metabolism, and relieve exercise fatigue. It is often used in sports nutritional supplements to delay muscle soreness.

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1. Common mild side effects

A small number of people may experience bloating, diarrhea, nausea or a burning sensation in the stomach, especially when taken on an empty stomach or in high doses.

Relief methods: Take with meals or reduce the dosage.

2. Risks of drug interaction (Three Prohibitions)

Tetrahydrocurcumin should not be taken together with anticoagulant/antiplatelet drugs, as it may inhibit platelet aggregation and increase the risk of bleeding.

It should not be used together with hypoglycemic drugs, as it may enhance the hypoglycemic effect and lead to hypoglycemia

It should not be used together with antidepressants either, as it may interfere with the activity of liver metabolic enzymes and affect the drug concentration.

3. Risks for special groups

Pregnant or lactating women should avoid using it.

Patients with biliary tract diseases should not use tetrahydrocurcumin products, as it may stimulate bile secretion and increase the risk of gallstones or bile duct blockage.

4.Tetrahydrocurcumin should not be used for a long time or in high doses. Excessive use will increase the burden on the liver and raise metabolic pressure.

1.Dosage control: The common dosage of dietary supplements is 50-200 mg per day. Follow the product instructions or the advice of your doctor.

2. Avoid taking with medication: especially anticoagulants and hypoglycemic drugs, with an interval of more than 2 hours.

3. Monitor reactions: Start with a small dose for the first use and observe if there is any allergic reaction or discomfort.

4. Choose regular products: Ensure there is no heavy metal pollution or illegal additives.

Tetrahydrocurcumin is regarded as an optimized alternative to curcumin due to its enhanced bioavailability and shows broad prospects in the fields of beauty and health. Tetrahydrocurcumin has good tolerance for short-term low-dose use, but potential risks need to be evaluated in combination with individual health conditions. If long-term or high-dose use is required (such as for disease treatment), it is recommended to do so under the guidance of a doctor or nutritionist.

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3.Tetrahydrocurcumin inhibits UVB-induced oxidative stress and melanogenesis in human melanocytes.
Photochemistry and Photobiology, 92(6), 794-804.

4.Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats.
Life Sciences, 79(18), 1720-1728.

5.Tetrahydrocurcumin ameliorates cognitive deficits and attenuates oxidative stress in a β-amyloid-induced Alzheimer's disease rat model.
Neurochemical Research, 43(3), 702-710.

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