Chemical Structure & Technical Specifications
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Item |
Specification |
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Product Name |
HBT1 |
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CAS Number |
489408-02-8 |
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Alternative Name |
YDL223C |
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IUPAC Name |
2-(((5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
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Molecular Formula |
C₁₆H₁₇F₃N₄O₂S |
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Molecular Weight |
386.39 g/mol |
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Appearance |
White to off-white crystalline powder |
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Purity |
≥98% HPLC, optional ≥99% HPLC |
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Solubility |
Soluble in DMSO (2mg/mL), slightly soluble in water |
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SMILES |
O=C(N)C1=C(NC(CN2C(C)=CC(C(F)(F)F)=N2)=O)SC3=C1CCCC3 |
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MDL Number |
MFCD02053612 |
Product Overview
HBT1 CAS 489408-02-8 | High Purity AMPA Receptor Potentiator
HBT1 CAS 489408-02-8 | High Purity AMPA Receptor Potentiator
High-purity HBT1 (CAS 489408-02-8), also known as YDL223C, is a selective AMPA receptor potentiator for neuroscience research, BDNF signaling and neuropsychiatric drug discovery. Factory supply, 98%+ HPLC, complete COA MSDS, global shipping.
Product Specifications
Chemical Properties
IUPAC Name: 2-[2-(5-Methyl-3-trifluoromethyl-1H-pyrazol-1-yl)acetylamino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide
Molecular Formula: C₁₆H₁₇F₃N₄O₂S
Molecular Weight: 386.39 g/mol
Purity: ≥99% (HPLC)
Appearance: White to off-white crystalline powder
Solubility: Soluble in DMSO (≥10 mg/mL)
Quality Control & Analysis
HPLC Purity Analysis: Certificate of Analysis provided with every batch
Mass Spectrometry: Confirmed molecular identity verification
NMR Spectroscopy: Structural integrity validation
Stability Testing: Verified shelf life under recommended storage conditions
Disclaimer: For laboratory research use only. Not for human consumption, clinical diagnosis or therapeutic administration.
HBT1, also referenced as YDL223C, is a novel, highly selective small-molecule positive allosteric modulator (PAM) of AMPA-type glutamate receptors. Unlike traditional AMPA potentiators that exhibit obvious intrinsic agonistic activity and unstable dose-dependent BDNF release, HBT1 features minimal self-agonistic effects and provides a linear, stable BDNF induction curve across a broad concentration range. This unique pharmacological property makes it a superior tool compound for reproducible neuronal experiments and preclinical neuropharmacology studies.
AMPA receptors mediate fast excitatory synaptic transmission in the central nervous system and are critical for synaptic plasticity, learning, memory, and neuronal survival. By selectively potentiating AMPA receptor activity in a glutamate-dependent manner, HBT1 effectively upregulates BDNF expression, making it widely used in research on Alzheimer's disease, cognitive impairment, depression, and other neuropsychiatric disorders. We provide high-purity HBT1 powder with stable batch quality, complete analytical documents, and flexible packaging for global research institutions, pharmaceutical laboratories, and biotech companies.
Product COA
Certificate Of Analysis
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Product Name |
HBT1 Powder |
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Chemical Formula |
C₁₆H₁₇F₃N₄O₂S |
Molecular Weight |
386.39 g/mol | |
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CAS |
489408-02-8 |
Batch Quantity |
400KG |
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|
Batch No. |
MLP-PPH-20231114 |
Manufacture Date |
2025.11.14 |
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Report Date |
2025.11.17 |
Retest Date |
2027.11.13 |
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Testing Items |
Specifications | Test Results | |
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BP2010 /EP6 |
Appearance |
crystalline powder |
Conforms |
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Melting point |
About 205°C |
206.4°C~206.7°C |
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|
Identification |
Meet the requirements |
Conforms |
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Appearance of solution |
Clear, not more intense than Y7 |
Conforms |
|
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PH |
2.4~3.0 |
2.60 |
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Loss on drying |
≤0.5% |
0.04% |
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Sulphated ash |
≤0.1% |
0.01% |
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Heavy metals |
≤20 ppm |
<20 ppm |
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Related substances |
≤0.25% |
Conforms |
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Assay |
99.0%~101.0% |
99.8% |
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USP32 |
Identification |
Meet the requirements |
Conforms |
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Loss on drying |
≤0.5% |
0.04% |
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Residue on ignition |
≤0.1% |
0.01% |
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Heavy metals |
≤0.003% |
<0.003% |
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Residue solvent - Ethanol |
≤0.5% |
<0.04% |
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Chloride |
16.9%~17.6% |
17.1% |
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Assay |
98.0%~102.0% |
100.0% |
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Conclusion: The product complies with BP2010/USP32/EP6 standard |
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Mechanism of Action
HBT1 acts as a potent and selective positive allosteric modulator of AMPA glutamate receptors with unique advantages over conventional analogs:
Glutamate-dependent potentiation: HBT1 binds to the ligand-binding domain (LBD) of AMPA receptors, enhancing channel opening and synaptic response only in the presence of endogenous glutamate, without causing undesired receptor over-activation.
No bell-shaped BDNF curve: Unlike traditional AMPA potentiators that show decreased BDNF induction at high concentrations, HBT1 maintains stable and continuous BDNF upregulation, greatly expanding the effective experimental concentration window.
Low intrinsic agonism: Minimal independent activation of AMPA receptors ensures low background noise, significantly improving the accuracy and repeatability of cell-based assays.
Activates neurotrophic pathways: Steady AMPA signaling enhancement promotes BDNF synthesis, supporting neuronal survival, synaptic repair, and cognitive function-related signal pathways.
Research Applications
Basic Neuroscience Research: Study AMPA receptor gating kinetics, synaptic transmission, synaptic plasticity, and BDNF-dependent neuronal signaling pathways.
Neurodegenerative Disease Research: Applied in in vitro and preclinical studies of Alzheimer's disease, memory loss, and cognitive dysfunction for neuroprotection mechanism exploration.
Psychiatric Pharmacology: Research on depression, anxiety, and mood disorders related to glutamatergic system dysfunction.
Drug Discovery & SAR Study: Serve as a standard tool compound and reference molecule for screening and optimizing new-generation AMPA receptor modulators.
Stable Cell Assay Development: Ideal for building high-stability neuronal screening platforms due to its linear dose-response performance.
Storage, Stability & Shipping
Our Product Advantages
High Purity & Stable Batch Consistency: 98%+ HPLC purity, strict impurity control, batch-to-batch stability for academic and industrial R&D.
Complete Supporting Documents: Provide COA, HPLC, NMR, MSDS for customs clearance and laboratory filing.
Flexible Packaging: 10mg, 50mg, 100mg, 500mg, 1g and bulk KG packaging available.
Factory Direct Supply: Professional production of neuro tool compounds, fast lead time and competitive price.
Global Export Service: Rich experience in international shipping, complete export documents, worldwide delivery.
Professional Technical Support: Provide solubility data, dissolution guidance and storage suggestions.
Inquiry & Quotation
If you are looking for high-quality HBT1 (CAS 489408-02-8), please contact us with your required quantity and purity specification. We will provide a formal quotation, product documents and customized packing solutions within working hours. Free COA sample is available for your evaluation.
SEO Keywords
HBT1 CAS 489408-02-8, YDL223C, HBT1 AMPA Receptor Potentiator, HBT1 98% HPLC, HBT1 Neuroscience Research Compound, BDNF Inducer, Neuro Drug Discovery Tool Compound
Applications in Neuroscience Research
HBT1 serves as an indispensable tool for investigating fundamental neurobiological processes and developing disease-modifying therapies:
Basic Neurobiology Research
Study of long-term potentiation (LTP) and memory formation mechanisms
Investigation of synaptic plasticity in physiological and pathological states
Characterization of AMPA receptor subtype-specific functions
Analysis of BDNF-dependent neuronal survival and differentiation pathways
Disease Modeling & Therapeutic Development
Alzheimer's disease: Restoration of synaptic function and cognitive enhancement
Parkinson's disease: Neuroprotective effects through BDNF upregulation
Depression: Rapid-acting antidepressant potential via AMPA modulation
Stroke: Neuroprotection and functional recovery after ischemic injury
Chronic pain: Modulation of central sensitization pathways
Research Protocols & Technical Resources
In Vitro Applications
Neuronal Culture Treatment:
Typical concentration range: 0.1-10 μM
Incubation time: 24-72 hours for BDNF expression studies
Optimize based on specific cell type and experimental endpoint
Electrophysiology Experiments:
Patch-clamp recording solutions: 1-5 μM HBT1 in extracellular buffer
Fast perfusion protocols for kinetic studies of receptor modulation
Biochemical Assays:
Western blotting: Detect BDNF, pCREB, and AMPA receptor subunit expression
ELISA kits: Quantify BDNF release in cell culture supernatants
In Vivo Administration Guidelines
Routes of Administration:
Intraperitoneal (IP): 1-10 mg/kg body weight
Intracerebroventricular (ICV): 0.1-1 μg per animal
Oral gavage: 5-20 mg/kg (formulated in corn oil or cyclodextrin)
Pharmacokinetic Profile:
Brain penetration: ~20% of plasma concentration
Half-life: 4-6 hours in rodent models
Metabolic pathway: Hepatic cytochrome P450-mediated clearance
Why Choose Our HBT1 Powder?
Production Process
Our HBT1 is manufactured through a state-of-the-art synthesis process featuring:
GMP-compliant production facilities
Advanced purification technologies (HPLC, recrystallization)
Stringent quality control at every stage
Traceable raw material sourcing
Certifications & Compliance
ISO 9001:2015 certified quality management system
REACH and TSCA compliance for international shipping
Custom regulatory documentation support for academic and industrial customers
Important Product Statement
CMS121 Powder (CAS 1353224-53-9) is only for scientific laboratory research and experimental study. It is not suitable for human consumption, clinical medical application, food, drug or cosmetic addition and daily use.
Get Free Sample & Latest Wholesale Quotation
If you are looking for a reliable and stable supplier of high-purity CMS121 Powder CAS 1353224-53-9 ACC1 inhibitor compound, welcome to contact us for free product samples, detailed COA test reports, customized specifications and the latest factory wholesale price. We will provide you with the most competitive price and professional one-stop service, and look forward to establishing long-term win-win cooperative relations with global partners!
Case Studies & Scientific Validation
Preclinical Research Highlights
Memory Enhancement in Animal Models
Study published in Journal of Pharmacology and Experimental Therapeutics demonstrated that HBT1 administration significantly improved spatial memory performance in Morris water maze tests, with effects lasting up to 72 hours post-treatment.
Neuroprotection in Ischemic Stroke Models
Research conducted at leading neuroscience institutions showed that HBT1 reduced infarct volume by 42% when administered 6 hours after transient middle cerebral artery occlusion in mice.
Antidepressant-like Effects
In forced swim test and tail suspension test paradigms, HBT1 exhibited rapid-acting antidepressant effects comparable to ketamine, but with reduced psychotomimetic side effects.
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Packaging & Shipping
Delivery Time:Around 3-5 workdays after your payment.
Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside
Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum
Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum
Storage:Stored in dry and cool place,keep away from strong light and heat.
Shelf Life:Two years when properly stored.
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Package |
1kg/bag ,25kg/bag;25kg/drum; customize as customer's equirements. |
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Transit |
Fedex, TNT,DHL,EMS,and so on. |
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Shipping port |
Shanghai/Tianjin/Dalian/Beijing/Xi'an |
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Lead Time |
1-2 working days upon received the payment |
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For mass orders, it will be delivered by air or sea. |
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FAQ
Q: 1. I want to know more details about the product, how can I contact you?
A: You can send us an email inquiry at any time. For more accurate quotes, I need the following information: product name, order quantity, receipt country, quality requirements, etc.
Q: 2. How do I know if your products are real or fake?
A: We will inspect every shipment. I can provide test reports including HPLC, MS and HNMR if you want. Please find a professional chemist to help you confirm the authenticity of the test report.
Of course, you can also purchase samples to take you around your trust.
Q: 3. How do you ensure the safety of the package I receive?
A: I want to receive the package safely, I first need to know your delivery address, do you have a preferred courier method, did you buy it from China?
Why do you want to know?
Because each country has different requirements for imported packages, especially chemical products, you need to know the basic information to provide you with the safest choice.
At present, we have professional customs clearance agents in EU countries, the United States, the United States, Canada, and Southeast Asia. We have professional customs clearance agents to ensure the safety of packages.
Q: 4. How to pay?
A: Our payment channels include bittoin, bank card, Western Union, Allegitudes, etc.
It is usually recommended that customers pay with Bitcoin, because the fee is low, the entry speed is fast, and the security is guaranteed.
Q: 5. How long does it take to receive the package?
A: This will vary according to the delivery method you choose. I will briefly introduce our commonly used special lines.
Usually European countries 10-15 days after sending you the tracking number.
In the United States and Canada, it usually takes 7-10 days.
Southeast Asian countries are 3-7 days.
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