99% Ru58841 Powder

99% Ru58841 Powder

Product Name:RU58841 Powder
Appearance:White Powder
Specification:99%
CAS:154992-24-2

Product Introduction

Product Full Name

RU58841

CAS Number

154992-24-2

IUPAC Name

4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Molecular Formula

C₁₇H₁₈F₃N₃O₃

Molecular Weight

369.34

Appearance

White to Off-White Fine Crystalline Powder

Purity

≥99% HPLC High Purity

Solubility

Freely soluble in DMSO, Ethanol, Methanol; slightly soluble in water

Grade Standard

Cosmetic Grade / Research Grade

Alias

HMR 3841, PSK-3841

Test Method

High Performance Liquid Chromatography (HPLC)

Storage Temperature

2°C – 8°C (Long-term)

Shelf Life

24 Months

 

Product Overview

 

RU58841 (CAS 154992-24-2) | 99% High Purity Androgen Receptor Antagonist Raw Powder

 

RU58841 (CAS 154992-24-2), also known as HMR 3841 or PSK-3841, is a high-efficiency, tissue-selective non-steroidal anti-androgen compound. Originally developed for targeting androgen-dependent physiological disorders, this premium active ingredient has become a core material in high-end cosmetic formulation, dermatological research, and hair loss intervention studies worldwide. Unlike steroidal anti-androgen ingredients, RU58841 delivers exclusive topical efficacy with zero systemic hormonal interference, ensuring higher safety and wider application compatibility.

As a potent and targeted DHT (Dihydrotestosterone) blocker, RU58841 competitively binds to androgen receptors located in human scalp hair follicles. It effectively blocks the combination of DHT and hair follicle receptors, fundamentally inhibiting DHT-induced hair follicle miniaturization, atrophy, and hair follicle dormancy. This mechanism perfectly targets the root cause of androgenetic alopecia, the most common type of hair loss for both men and women. It can effectively revive dormant hair follicles, improve scalp microcirculation, accelerate hair follicle metabolism, and significantly enhance hair density and thickness.

Compared with traditional hair growth active ingredients such as Minoxidil and Finasteride, RU58841 features stronger receptor affinity, longer biological half-life, more stable topical activity, and no systemic side effects. It does not affect the body's overall hormone balance, making it safer for long-term topical use. At present, it is widely recognized as a top-tier raw material for high-end anti-hair-loss serums, scalp care sprays, and professional dermatological research. We supply factory-direct RU58841 powder with 99% high purity, strict batch-to-batch quality control, complete authoritative certifications, and stable global bulk supply for cosmetic manufacturers, research laboratories, and global distributors.

 

Ru58841

 
 

Product COA

 

Certificate Of Analysis

 

Product Name

RU 58841 Powder

product-402-240

Molecular Formula

C17H18F3N3O3

Cas No.

154992-24-2

Quantity

1400KG

MFG. Date

2025.04. 11

Batch No

MLP-PEA-20250411

Report Date

2025.04. 17

Retest Date

2027.04. 10

 

Testing Items

Specifications

Results

Appearance

Fine white to off-white crystal powder

Conforms

Color

White to Off-white

Conforms

Identification

NMR

Conforms

Loss on Drying

≤ 1.0%

0.24%

Water

≤ 1.0%

0. 17%

Residue on ignition

≤ 0. 10%

0.06%

Purity (HPLC)

≥ 99.0%

99.51%

Heavy metal

Lead(Pb),mg/kg

≤ 0.5

Conforms

Total arsenic(As),

mg/kg

≤ 0. 15

Conforms

Cadmium(Cd),mg/kg

≤ 2.5

Conforms

Total mercury(Hg),

mg/kg

≤ 1.5

Conforms

Solvent residue

Methanol

≤ 0.3%

Not detected

Ethanol

≤ 0.5%

Not detected

 

Ethyl acetate

≤ 0.5%

Not detected

Microbiological control

Total Plate Count

≤ 10,000cfu/g

Conforms

Yeast & Mold

≤ 300cfu/g

Conforms

Coliforms

≤ 10cfu/g

Conforms

E.Coli

Negative/10g

Conforms

Salmonella sp.

Negative/25g

Conforms

Staph Aureus

Negative/10g

Conforms

Pseudomonas

aeruginosa

Negative/25g

Conforms

Conclusion

Conform with the in-house standard

Packing and Storage

Packing

Pack in paper-drums and PE bags inside.

25Kg/Drum

Storage

Store in a well-closed container away from moisture and direct sunlight

 

Working Mechanism of RU58841

 

Androgenetic alopecia is mainly caused by the excessive combination of DHT and hair follicle androgen receptors, which leads to continuous hair follicle shrinkage, shortened hair growth cycle, and progressive hair thinning. RU58841 exerts its anti-hair-loss and hair-regrowth effects through a precise and scientific targeted mechanism.

As a selective non-steroidal androgen receptor antagonist, RU58841 possesses extremely high receptor binding affinity. When applied topically to the scalp, it preferentially binds to androgen receptors in hair follicle cells, occupying the binding sites of DHT. It effectively blocks DHT from attaching to hair follicle receptors, terminates the adverse biological reaction caused by DHT, and stops hair follicle atrophy and damage.

Furthermore, RU58841 can improve scalp blood microcirculation, supplement nutrient supply for hair follicles, activate dormant hair follicle stem cells, prolong the anagen phase of hair growth, and shorten the telogen phase. Different from systemic anti-androgen substances, RU58841 only acts locally on the scalp without entering the systemic circulation in large quantities, so it will not interfere with human endocrine and hormone levels, ensuring high safety for long-term topical application.

 

Core Competitive Advantages

99% Ultra-High Purity & Strict Impurity Control: Our RU58841 powder is produced through multi-stage chemical synthesis, repeated recrystallization and high-precision purification technology. The HPLC purity is stably above 99%, with ultra-low organic impurities and zero heavy metal residues. All products comply with EU cosmetic raw material standards and international research chemical specifications, fully meeting the strict requirements of high-end cosmetic formula development and academic laboratory precision experiments.

Superior Targeted DHT Blocking Efficacy: RU58841 has stronger androgen receptor affinity than conventional anti-hair-loss ingredients. It can efficiently and competitively block DHT-induced hair follicle damage, reverse follicle miniaturization, activate atrophic hair follicles, and promote healthy hair regrowth. The effect is more stable, lasting and obvious for hereditary hair loss, androgenetic alopecia and hormone-induced hair thinning.

Long-Lasting Stable Topical Activity: Featuring stable chemical molecular structure, RU58841 is not easy to decompose in conventional cosmetic solvents and liquid formulas. Its effective topical activity can last up to 48 hours, greatly improving the durability of product efficacy. It perfectly adapts to long-acting scalp care products and reduces the frequency of repeated use, bringing better user experience.

High Safety & Excellent Formula Compatibility: Adopting non-steroidal molecular structure, RU58841 completely avoids systemic hormone side effects. It is mild and non-irritating to scalp skin, without sensitization, redness or swelling risks. It has high compatibility with ethanol, DMSO, plant extracts and various cosmetic base materials, with simple formula matching and stable long-term storage performance.

Complete Authoritative Documents & Traceable Quality: Every batch of our RU58841 is accompanied by complete formal documents, including COA quality inspection report, HPLC spectrum analysis report, MSDS safety data sheet, and technical datasheet. All product quality is fully traceable, supporting global customer customs clearance, product registration, brand filing and laboratory audit work.

Flexible MOQ & Stable Global Supply Capacity: We support diversified order modes including sample testing, small-batch trial customization and large-tonnage bulk orders. Sufficient raw material inventory ensures fast delivery, and we provide customized packaging solutions according to customer demands, serving global cosmetic manufacturers, scientific research institutions and distributors efficiently.

Wide Application Fields

RU58841 (CAS 154992-24-2) is a high-value multifunctional active ingredient, widely applied in commercial cosmetic production and professional biomedical scientific research, with mature and reliable application scenarios covering multiple fields:

High-End Anti-Hair Loss & Hair Regrowth Cosmetics: As the core functional active ingredient, it is widely used in premium hair regrowth serums, scalp repair sprays, anti-alopecia lotions and scalp conditioning essences. It is specially developed for male and female androgenetic alopecia, hereditary hair loss, post-hormone-imbalance hair thinning and diffuse hair loss problems, helping users improve hair density and restore healthy scalp state.

Professional Dermatological & Biomedical Research: It serves as a key research reagent for global university laboratories, pharmaceutical R&D centers and biomedical research institutions. It is mainly used for in-depth research on androgen receptor signaling pathways, hair follicle growth metabolism, androgen-dependent alopecia intervention, as well as auxiliary research on hirsutism and hormonal acne intervention mechanisms.

Customized High-End Scalp Care Formulas: Applied in customized private-label scalp care products, it can effectively improve fine and soft hair, reduce intermittent hair shedding, repair damaged scalp microenvironment, and maintain long-term scalp and hair health, which is favored by high-end personal care customization brands.

 

Storage & Handling Guidelines

Professional Storage Conditions: Store RU58841 powder in a fully sealed, moisture-proof container, placed in a cool, dry, dark and well-ventilated indoor environment. Long-term stable storage is recommended at 2–8°C. Strictly avoid direct sunlight, high temperature environment and humid air to prevent moisture absorption, oxidation and structural deterioration, so as to ensure the stability of product purity and biological activity.

Valid Shelf Life: Under standard sealed low-temperature storage conditions, the product maintains stable chemical properties and effective activity for 24 months. It is recommended to seal and store in batches after opening to avoid long-term exposure to air.

Safe Operating Instructions: Professional protective gloves and goggles must be worn during material taking and experimental operation to avoid direct skin and eye contact, as well as dust inhalation. The operating environment should be kept ventilated. After each use, the container must be tightly sealed immediately to isolate air and moisture. Waste materials need to be disposed of in accordance with chemical safety specifications.

Quality Assurance System

We implement a strict full-process quality management system for all RU58841 products, from raw material screening, synthetic reaction, purification and filtration to finished product packaging and delivery. Every production link is strictly monitored and tested. Each batch of products will undergo HPLC purity detection, impurity analysis, solubility test and appearance inspection before leaving the factory to ensure that the product indicators fully meet the standard requirements.

We insist on batch-to-batch quality consistency, eliminate unqualified products from delivery, and provide complete quality traceability reports. Whether it is small-batch laboratory research samples or large-batch industrial production raw materials, we maintain the same high-quality standards, providing reliable raw material guarantee for customers' product development and scientific research projects.

FAQ

Q1: What is the core advantage of RU58841 compared with other hair growth ingredients? A1: RU58841 is a targeted local DHT blocker with no systemic hormonal side effects. It has higher receptor affinity, longer efficacy duration and better safety than traditional ingredients, and will not affect human endocrine balance during long-term use.

Q2: Is RU58841 suitable for cosmetic formula development? A2: Yes. Our 99% high-purity RU58841 is cosmetic-grade, with low irritation and good compatibility with various cosmetic solvents and base materials. It is very suitable for the development of various scalp care and anti-hair-loss finished products.

Q3: What kinds of packaging and delivery services do you provide? A3: We support multiple packaging specifications from gram-level samples to kilogram-level bulk goods, and support customized packaging. We have sufficient inventory all year round, support global fast shipping, and provide professional after-sales tracking service.

Q4: Can you provide technical support for formula application? A4: Yes. Our professional technical team can provide customers with formula matching suggestions, solubility guidance and application technical support to help customers quickly complete product development and trial production.

Professional Global Services

 

We are a reliable professional global supplier focusing on high-purity cosmetic active ingredients and biochemical research raw materials. With standardized production workshops, complete testing equipment and mature supply chain system, we guarantee stable quality and sufficient inventory of RU58841 (CAS 154992-24-2) all year round. We provide one-stop professional services covering free sample testing, personalized formula technical guidance, customized packaging, factory competitive wholesale prices and flexible order solutions.

Our 24/7 online professional support team provides efficient product consultation, technical problem solving, order tracking and perfect after-sales guarantee services for global cosmetic manufacturers, scientific research laboratories, brand operators and industry distributors. We adhere to the service tenet of quality first and customer priority, and strive to create maximum value for every customer.

Contact us today to get the latest RU58841 (CAS 154992-24-2) wholesale quotation, full set of certified test documents, and professional technical support!

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Packaging & Shipping

 

Weight

Packing method

1kg

bag/kg, box outside (double plastic bag + Aluminum foil bag inside)

10kgs,25kg or more

by Drums or carton (3 layers plastic bag inside)

 

Weight

Delivery mothod

Delivery time

1kg-25kgs

EMS,DHL,UPS,Fedex,TNT

3-7days

25kgs-100kgs

DHL,FedEx,by Air

3-7days

more than 100kgs

by Air

3-7days

by Sea

10-35days

 

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FAQ

 

Q: 1. Who are we?

A: We are based in Shandong, China, start from 2020,sell to Domestic Market(45.00%),Western Europe(10.00%),Eastern Asia(10.00%),North America(10.00%),Africa(5.00%),Central America(5.00%),Southeast Asia(5.00%),South America(5.00%),Mid East(5.00%). There are total about 51-100 people in our office.

Q: 2. How can we guarantee quality?

A: Always a pre-production sample before mass production; Always final Inspection before shipment;

Q: 3. What can you buy from us?

A: Fluorescent whitening agents, pigments and dyes, pharmaceutical intermediates, paint decoration, pharmaceutical impurities and other products.

Q: 4.Why should you buy from us not from other suppliers?

A: RD &marketing experience products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Q: 5.What services can we provide?

A: Accepted Delivery Terms: FOB,CFR,CIF,EXW,FAS,CIP,CPT,DDU,Express Delivery; Accepted Payment Currency:USD,EUR,CNY; Accepted Payment Type: T/T,L/C,D/P D/A,Western Union,Cash; Language Spoken:English,Chinese.

 

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