Fluorene Myristate Powder

Fluorene Myristate is an organic compound that is a fatty acid ester formed from fluorenic acid and myristic acid. Its molecular formula is C27H36O2, and its properties are white to light yellow solid, usually in powder form, with a waxy smell. Its heavy myristic acid (also known as myristic acid, is a saturated fatty acid. The scientific name is fluorenyl myristate (myristic acid), It is white to yellowish white hard solid, occasionally shiny crystalline solid, or white to yellowish white powder, odorless. In nature, myristic acid exists in vegetable oils such as cardamom oil, palm oil, and coconut oil in the form of glyceride. It is mainly used as a raw material for the production of surfactants, for the production of sorbitan fatty acid esters, glycerin fatty acid esters, ethylene glycol glycol fatty acid esters, etc., and can also be used for the production of isopropyl myristate. It is also used as defoamer and flavor enhancer. According to GB2760-89, it can be used to prepare various edible spices.

Fluorene Myristate, chemically named 9H-fluoren-9-yl tetradecanoate, CAS No. 2595050-21-6, is a synthetic lipophilic ester compound formed by the esterification reaction between fluorene and myristic acid. It is commercially supplied as fine crystalline powder.

Basic Physical Characteristics

Fluorene Myristate powder appears as white to off-white or pale yellow crystalline solid. It has low water solubility and excellent solubility in various lipophilic media, including medium-chain triglycerides, vegetable oils, ethanol, acetone and other common organic solvents. The substance features relatively stable chemical properties under normal ambient conditions, with good thermal stability within conventional processing temperature ranges. It is not prone to rapid hydrolysis in neutral lipid systems and demonstrates favorable compatibility with most oil-phase raw materials used in cosmetics and laboratory formulations.

Chemical Structure Feature

Its molecular structure combines the fluorene aromatic ring moiety and a long-chain myristate alkyl group. The fluorene skeleton endows the compound with antioxidant potential and biological activity related to neuronal research, while the long-chain myristate group provides lipophilicity, emollient properties and good affinity with lipid biomembranes. This unique structural combination distinguishes it from ordinary simple fatty acid esters.

Core Profile Overview

Fluorene Myristate is classified as a high-purity fine chemical research material. It is widely used as a research compound for central nervous system related studies, cosmetic functional additive, organic synthetic intermediate and auxiliary penetration agent in lipid delivery systems. It should be emphasized that this product is mainly intended for laboratory research, formulation feasibility tests and preclinical study. Any application involving direct oral administration or human commercial consumption needs to comply fully with local food, dietary supplement and pharmaceutical regulatory requirements.

Supplementary Formulation Property

When incorporated into emulsion or anhydrous oil formulas, it brings silky spreading texture without heavy greasiness. It can form a breathable thin film on lipid interfaces, help reduce water evaporation, and synergistically boost the antioxidative performance of other active ingredients in the system.

Short condensed version (for front page brief introduction)

Fluorene Myristate (9H-fluoren-9-yl tetradecanoate, CAS 2595050-21-6) is a lipophilic crystalline ester powder synthesized from fluorene and myristic acid. Owning to its integrated aromatic fluorene structure and long-chain fatty ester group, it combines antioxidative activity and outstanding oil solubility. It serves as a multi-purpose research raw material for cognitive-related laboratory studies, cosmetic emollient additive, organic synthesis intermediate and mild penetration enhancer in lipid formulations. The material is primarily offered for research use, and relevant regulatory verification is mandatory prior to commercial human consumption applications.

Fluorene Myristate is a lipophilic synthetic ester formed by fluorene and myristic acid, appearing as white to pale yellow crystalline powder. It is a multifunctional raw material applicable to cosmetic formulations, research-grade pharmaceutical intermediates and nootropic dietary supplement raw materials.

1. Nootropic & Cognitive Support Functions

Fluorene Myristate acts as a cognitive enhancer for healthy individuals. It helps improve mental alertness, sustain attention span and strengthen concentration. It supports working memory, enhances learning efficiency and lifts mental motivation, which benefits people facing heavy intellectual workloads. In addition, it contributes to improving thinking clarity and creativity by regulating neuronal oxidative balance.

2. Broad-Spectrum Antioxidant Activity

This compound possesses notable free radical scavenging capacity. It mitigates oxidative stress caused by reactive oxygen species, protects cell membranes and biomolecules from peroxidation damage. Antioxidant effects slow down cell aging processes, support long-term neural cell health, and reduce oxidative damage triggered by environmental stressors.

3. Cosmetic Functions (Topical Application)

Skin Conditioning & Emollient: It works as a lightweight emollient. When incorporated into creams, lotions and serums, it delivers soft, smooth skin feel without heavy greasiness.

Moisturization & Barrier Protection: It forms a uniform, breathable protective film on the skin surface to reduce transepidermal water loss, relieve dry and flaky skin, and reinforce the integrity of the skin barrier.

Improve Formulation Performance: It improves the spreadability of finished cosmetic products and shows good compatibility with various oils, waxes and lipophilic active ingredients. It can also stabilize lipid-based formulas and delay ingredient oxidation.

4. Respiratory Support (Reported Activity)

Fluorene Myristate exhibits expectorant properties. It helps thin accumulated mucus in the respiratory tract, facilitating mucus clearance and easing congestion and discomfort associated with cough.

5. Formulation Advantages

The powder features excellent liposolubility, good thermal stability and favorable biocompatibility. It can be used as a lipophilic carrier auxiliary material to assist the penetration of other lipophilic active components. It is insoluble in water and freely soluble in common organic solvents such as ethanol, acetone and medium-chain oils, bringing great flexibility for formula development.

High Purity: Produced through natural extraction and precision manufacturing, ensuring excellent bioavailability

Safety: Derived from natural compounds with low risk of irritation or allergic reactions

Stability: Maintains activity across various environmental conditions and storage scenarios

Antioxidant Properties: Helps protect cells and tissues from oxidative damage

Fluorene Myristate (9H-fluoren-9-yl tetradecanoate) is a lipophilic crystalline ester powder with unique amphipathic properties, excellent lipid solubility and stable chemical structure. It has versatile application prospects in cognitive research materials, cosmetic raw materials, pharmaceutical intermediates and lab formulation development.

1. Nootropic Research Raw Material

Fluorene Myristate is widely adopted as a research compound for cognitive function studies. It is used in laboratory trials exploring agents for supporting attention, working memory and mental clarity. Researchers utilize it to investigate mechanisms related to neuronal oxidative balance and central nervous system comfort. It serves as a core test substance in preclinical research focusing on healthy cognitive maintenance.

Reminder: This material is primarily for laboratory research purposes. Any oral human consumption application must comply with local food supplement and pharmaceutical regulatory standards.

2. Cosmetic & Personal Care Industry

As a lipophilic cosmetic active additive, Fluorene Myristate can be incorporated into various oil-based and emulsion formulations:

Facial creams, moisturizing lotions, facial serums and repair balms;

Body moisturizers, massage oils and anhydrous skincare sticks;

Lip care products and leave-on hair conditioning formulations.

Its functions in cosmetics include acting as a lightweight emollient, forming a breathable protective film on the skin surface to reduce transepidermal water loss, improving product spreadability, and enhancing the antioxidative performance of cosmetic systems. It displays good compatibility with plant oils, esters, waxes and other lipophilic actives. It helps deliver a non-greasy, silky skin feel without creating heavy residue.

3. Pharmaceutical Intermediate & Synthesis Building Block

The fluorene ester skeleton of Fluorene Myristate makes it a valuable synthetic intermediate. It can participate in further organic synthesis reactions to produce other fluorene-derivative compounds with targeted biological activity. It is commonly stocked in chemical laboratories and fine chemical factories for custom synthesis projects targeting new drug candidates and bioactive molecules.

4. Auxiliary Penetration Enhancer in Formulation Systems

Thanks to its moderate lipophilicity, Fluorene Myristate acts as a mild penetration aid in lipid formulations. It assists other lipophilic active ingredients to pass through lipid barriers. It is applied in research formulations of transdermal test preparations and liposomal carrier systems to optimize the delivery efficiency of hydrophobic actives.

5. Laboratory Research Reagent

It is supplied as high-purity powder for academic institutions, biotechnology labs and pharmaceutical R&D teams. Typical lab uses include cell culture related tests, antioxidant activity evaluation, compound solubility research and formulation feasibility experiments for novel lipid-based delivery systems.

Key Formulation Notes

Insoluble in water; freely soluble in ethanol, medium-chain triglycerides, acetone and other organic solvents;

Suitable for low-to-medium temperature production processes; avoid prolonged exposure to strong ultraviolet light;

Recommended addition ratio depends on final product category and targeted effect; formulation screening is required before mass production.

Dosage & Safety: Flmodafinil is intended for short-term use. Typical doses range from 50-200mg daily. Side effects may include insomnia, headaches, or increased heart rate at higher doses.

Legal Status: It is not approved for medical use in most countries and is primarily available for research purposes.

Storage: Should be stored in a cool, dry, dark place with a shelf life of up to 24 months when properly preserved.

⚗️ Chemical Structural Differences

Flmodafinil is a difluoro derivative of Modafinil, with two fluorine atoms added to the para-position of the diphenylmethyl group in its molecular structure. This modification fundamentally alters the pharmacological properties of the drug:

Modafinil: Molecular formula C₁₅H₁₅NO₂S, molecular weight 273.35

Flmodafinil: Molecular formula C₁₅H₁₃F₂NO₂S, molecular weight 309.33

The high electronegativity of fluorine atoms enhances the binding affinity between the molecule and its target, while improving blood-brain barrier penetration efficiency

🎯 Mechanism of Action Differences

Both compounds increase synaptic dopamine levels by inhibiting the dopamine transporter (DAT), but differ in potency and selectivity:

Binding Affinity:

Flmodafinil has 3-4 times higher affinity for DAT than Modafinil (Ki values of 1.4μM vs 4.5μM respectively)

It shows weaker inhibition of norepinephrine transporter (NET) and serotonin transporter (SERT), reducing cardiovascular side effects

Pathway Specificity:

Modafinil also activates the orexin system and glutamatergic neurons

Flmodafinil acts almost exclusively through the dopamine pathway, with a more precise mechanism of action

📊 Pharmacokinetic Differences

💊 Pharmacodynamic Differences

Potency and Dosage:

Flmodafinil is 2-3 times more potent than Modafinil, with an effective dose range of 50-150mg/day

The conventional therapeutic dose of Modafinil is 200-400mg/day

Duration of Action:

Flmodafinil maintains wakefulness for 12-16 hours

Modafinil's effects last approximately 8-12 hours

Cognitive Enhancement:

Flmodafinil shows superior performance in tests of attention, working memory, and reaction speed

Modafinil provides more balanced mood improvement and anti-fatigue effects

⚠️ Safety and Tolerability Differences

Common Side Effects:

Modafinil: Headache, nausea, insomnia (incidence ~10-15%)

Flmodafinil: Headache, anxiety, insomnia (slightly higher incidence ~15-20%)

Drug Interactions:

Modafinil may induce CYP3A4, affecting metabolism of other drugs

Flmodafinil has minimal impact on CYP enzymes, resulting in lower risk of drug interactions

Abuse Potential:

Flmodafinil's stronger dopamine-releasing effect theoretically gives it slightly higher abuse potential than Modafinil

Neither compound is currently classified as a controlled substance, but rational use is advised

📈 Clinical Application Differences

Sleep Disorder Treatment:

Modafinil is FDA-approved for the treatment of narcolepsy, sleep apnea, and shift work sleep disorder

Flmodafinil is currently in clinical research stages and has not received approval for medical use

Cognitive Enhancement:

Flmodafinil demonstrates more significant cognitive improvement in healthy individuals, often used for academic and workplace performance enhancement

Modafinil is more commonly used for medical wakefulness maintenance

Neuropsychiatric Disorders:

Modafinil has been studied as an adjunct therapy for depression, ADHD, and Parkinson's disease

Research on Flmodafinil focuses primarily on cognitive impairment and neuroprotection

Other Nootropics Raw Material Also Available

Delivery Time:Around 3-5 workdays after your payment.

Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside

Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum

Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum

Storage:Stored in dry and cool place,keep away from strong light and heat.

Shelf Life:Two years when properly stored.

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