Chemical Structure & Technical Specifications
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Item |
Specification |
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Product Name |
Nooglutyl |
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Alternative Names |
Nooglutil, ONK-10 |
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CAS Number |
112193-35-8 |
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IUPAC Name |
(2S)-2-[(5-hydroxypyridine-3-carbonyl)amino]pentanedioic acid |
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Molecular Formula |
C₁₁H₁₂N₂O₆ |
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Molecular Weight |
268.22 g/mol |
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Appearance |
White to off-white crystalline powder |
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Purity Grade |
≥98% HPLC, ≥99% HPLC Optional |
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Solubility |
Soluble in water and DMSO, slightly soluble in ethanol |
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SMILES |
C1=C(C=NC=C1O)C(=O)N[C@@H](CCC(=O)O)C(=O)O |
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Shelf Life |
24 months under sealed and proper storage conditions |
Product Overview
Nooglutyl CAS 112193-35-8 | High Purity Nootropic Cognitive Research Powder
High-purity Nooglutyl (CAS 112193-35-8), also known as Nooglutil/ONK-10, is a potent nootropic compound for cognitive enhancement, neuroprotection and glutamatergic pathway research. Factory supply 98%/99% HPLC, complete COA MSDS, global shipping.
Disclaimer: For laboratory research use only. Not for human consumption, clinical diagnosis, therapeutic administration, food, feed or cosmetic applications.
Nooglutyl, also commonly named Nooglutil or ONK-10, is a classic synthetic nootropic and neuroprotective compound first developed for neurological and cognitive functional research. As a high-efficiency glutamatergic modulator, it exhibits superior cognitive regulation activity compared with conventional nootropic analogs, featuring stable pharmacological properties and low experimental toxicity. Widely adopted in global neuroscience laboratories and pharmaceutical R&D institutions, Nooglutyl serves as a core tool compound for exploring learning and memory mechanisms, cerebral ischemia injury protection, and neurocognitive disorder intervention.
Distinct from common nootropic reagents, Nooglutyl dual-regulates central nervous system excitatory signaling pathways. It effectively modulates AMPA and glutamate receptor activity, promotes acetylcholine release in brain tissues, improves neuronal energy metabolism, and enhances memory formation and information retention. Meanwhile, it exerts prominent neuroprotective effects against ischemic brain damage, oxidative stress and neuronal apoptosis, making it an essential research material for preclinical studies on brain injury repair, cognitive decline and neurodegenerative diseases. We supply premium-grade Nooglutyl powder with strict HPLC purity control, consistent batch-to-batch stability, complete certification documents and flexible packaging solutions to support global academic research and pharmaceutical drug development projects.
Product COA
Certificate Of Analysis
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Product Name |
Nooglutyl Powder |
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Chemical Formula |
C11H12N2O6 |
Molecular Weight |
268.22 | |
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CAS |
112193-35-8 |
Batch Quantity |
400KG |
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Batch No. |
MLP-PPH-20231114 |
Manufacture Date |
2025.11.14 |
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Report Date |
2025.11.17 |
Retest Date |
2027.11.13 |
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Testing Items |
Specifications | Test Results | |
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BP2010 /EP6 |
Appearance |
crystalline powder |
Conforms |
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Melting point |
About 205°C |
206.4°C~206.7°C |
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Identification |
Meet the requirements |
Conforms |
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Appearance of solution |
Clear, not more intense than Y7 |
Conforms |
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PH |
2.4~3.0 |
2.60 |
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Loss on drying |
≤0.5% |
0.04% |
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Sulphated ash |
≤0.1% |
0.01% |
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Heavy metals |
≤20 ppm |
<20 ppm |
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Related substances |
≤0.25% |
Conforms |
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Assay |
99.0%~101.0% |
99.8% |
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USP32 |
Identification |
Meet the requirements |
Conforms |
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Loss on drying |
≤0.5% |
0.04% |
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Residue on ignition |
≤0.1% |
0.01% |
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Heavy metals |
≤0.003% |
<0.003% |
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Residue solvent - Ethanol |
≤0.5% |
<0.04% |
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Chloride |
16.9%~17.6% |
17.1% |
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Assay |
98.0%~102.0% |
100.0% |
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Conclusion: The product complies with BP2010/USP32/EP6 standard |
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Mechanism of Action & Pharmacological Characteristics
Chemical Properties & Quality Specifications
Technical Parameters
IUPAC Name: N-(5-Hydroxynicotinoyl)-L-glutamic acid
Molecular Formula: C₁₁H₁₂N₂O₆
Molecular Weight: 268.23 g/mol
CAS Number: 112193-35-8
Synonyms: Nooglutil, ONK-10, L-Glutamic acid, N-[(5-hydroxy-3-pyridinyl)carbonyl]-
Purity: ≥99% (HPLC)
Appearance: White to off-white crystalline powder
Solubility: Soluble in water (10 mg/mL), DMSO, and ethanol
Nooglutyl (CAS 112193-35-8) is a multifunctional neuroactive small molecule with dual nootropic and neuroprotective properties, featuring unique pharmacological advantages over conventional cognitive research compounds:
Potent Glutamatergic Modulation: Nooglutyl targets and regulates central glutamate receptors and AMPA receptor signaling pathways, effectively optimizing excitatory synaptic transmission in the brain. Its regulatory activity on cognitive-related receptors is significantly stronger than many mainstream nootropic compounds, enabling more efficient induction of synaptic plasticity and laying a foundation for learning and memory improvement research.
Cholinergic System Activation: The compound can promote the endogenous release of acetylcholine in neuronal tissues, enhance brain energy metabolism and information transmission efficiency, improve neuronal activity and anti-fatigue ability, and support in-depth research on focus regulation, information processing and memory consolidation mechanisms.
Excellent Neuroprotective Effect: It effectively resists neuronal damage caused by cerebral ischemia, hypoxia and oxidative stress, inhibits neuronal apoptosis, and repairs damaged synaptic structures. This core property makes it a key tool for preclinical research on stroke-induced brain injury and secondary cognitive dysfunction.
High Biosafety & Stable Dose Response: Nooglutyl has low intrinsic cytotoxicity and a wide safe experimental concentration window. It maintains stable pharmacological activity in long-term cell and animal experiments without obvious drug resistance or side effects, ensuring high repeatability and accuracy of experimental data.
Improve Cognitive Retention Ability: Different from single-function cognitive enhancers, it can simultaneously optimize memory formation, consolidation and recall processes, providing reliable experimental support for exploring intervention schemes for age-related cognitive decline.
Core Research Applications
As a high-value nootropic tool compound and pharmaceutical intermediate, Nooglutyl is widely used in multiple fields of neuroscience research and drug development:
Cognitive Function Research: Applied in basic research on learning ability, memory formation, information retention and attention regulation; used to explore the molecular mechanism of cognitive aging and brain functional metabolism.
Neuroprotection & Brain Injury Research: Core material for in vitro and in vivo experiments on cerebral ischemia injury, hypoxic brain damage and oxidative neuronal injury, supporting the development of neuroprotective candidate drugs.
Neurodegenerative Disease Study: Used in preclinical research on Alzheimer's disease, vascular dementia and mild cognitive impairment, exploring effective intervention targets and therapeutic pathways for cognitive disorders.
Glutamatergic Signaling Pathway Research: Serve as a standard modulator for studying AMPA receptor and glutamate receptor activation mechanisms, synaptic transmission and neuronal signal transduction networks.
Pharmaceutical Intermediate Development: As a key synthetic intermediate for new neuroactive drugs and nootropic pharmaceutical ingredients, supporting SAR (structure-activity relationship) research and new drug lead compound optimization.
Neurological Pharmacological Assay Development: Used to build stable cognitive drug screening models and neuronal functional detection platforms for high-throughput screening of new neuroprotective and nootropic compounds.
Storage, Stability & International Shipping Instructions
Long-term Storage Conditions: Store in a tightly sealed container at low temperature (2-8°C for short-term, -20°C for long-term storage), keep dry, dark and away from moisture and high temperature environment. The valid shelf life is 24 months under standard sealed storage.
Solution Stability: Aqueous and DMSO stock solutions are freshly prepared for optimal experimental results. Avoid repeated freeze-thaw cycles. The diluted solution is recommended to be used within 7 days for stable activity.
Daily Handling Notes: Avoid direct exposure to strong light and humid air. Wear professional experimental protective equipment during weighing and sample preparation to prevent dust inhalation and contact irritation.
Professional Export Packaging: Adopt vacuum aluminum foil bag sealed packaging for small batches, and food-grade drum packaging for bulk orders. All products are protected from light and moisture, with ice pack constant temperature transportation for international shipments to ensure product activity and purity stability during transit.
Important Notice: Nooglutyl (CAS 112193-35-8) is strictly limited to scientific laboratory research use only. It is not approved for clinical treatment, human and animal feeding, food additives, cosmetics or civilian use. Buyers shall confirm the local import regulatory policies and compliance requirements before placing orders.
Our Product & Supply Advantages
High Purity & Strict Quality Control: Provide 98%/99% high-purity Nooglutyl powder, with strict control of heavy metals, residual solvents and impurities. Batch HPLC testing ensures stable and consistent product quality, fully meeting academic and industrial R&D standards.
Complete Official Documents: Free provision of COA, HPLC detection report, MSDS safety data sheet, technical data sheet and other supporting documents, which can be directly used for laboratory filing and global customs clearance.
Flexible Custom Packaging: Support multiple specifications including 10mg, 50mg, 100mg, 500mg, 1g laboratory small packages and kilogram-level bulk wholesale. Support customized vacuum sealing and labeling services.
Factory Direct Supply & Fast Delivery: Independent production workshop and sufficient spot inventory, eliminate intermediate dealers, ensure competitive ex-factory price and short production lead time, support urgent order delivery.
Professional Global Export Service: Rich experience in cross-border chemical raw material export, complete export declaration documents, support multi-country logistics delivery and diversified payment methods, safe and efficient global shipping.
One-stop Technical Support: Provide professional technical guidance including product solubility parameters, dissolution methods, experimental dosage reference and storage schemes to solve customers' experimental application problems.
Inquiry & Quotation
If you need high-purity Nooglutyl (CAS 112193-35-8) for your laboratory research or pharmaceutical R&D projects, please feel free to contact us with your required purity grade, quantity and destination country. We will provide you with a formal detailed quotation, complete product documents and customized packaging solutions within working hours. Free COA sample evaluation service is available for bulk order customers.
SEO Keywords
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Applications & Therapeutic Potential
Cognitive Enhancement
Improves memory retention and learning capabilities
Enhances focus, mental clarity, and concentration
Supports cognitive performance in academic and professional settings
May help age-related cognitive decline
Neuroprotection
Protects against ischemic neuronal damage and brain injury
Exhibits antihypoxic and antiamnesic properties
Potential for treating neurodegenerative diseases (Alzheimer's, Parkinson's)
Supports recovery from stroke and traumatic brain injury
Research Applications
Investigating glutamate and dopamine receptor interactions
Studying synaptic plasticity and memory formation mechanisms
Developing novel treatments for cognitive disorders
Exploring neuroprotective strategies in animal models
Scientific Research & Clinical Studies
Preclinical Research Highlights
Memory Enhancement
Studies demonstrate significant improvement in memory creation and retention in animal models, with enhanced cognitive processes observed across multiple learning paradigms.
Neuroprotection
Nooglutyl exhibits potent antihypoxic properties, protecting against ischemic neuronal damage and reducing brain injury in stroke models.
Anxiolytic Effects
Modulation of dopamine D2 receptors in the striatum results in significant anti-anxiety effects without sedation or motor impairment.
Anti-Amnesic Properties
Prevents memory impairment caused by various amnesic agents, showing promise for treating memory disorders.
Published Research References
Voronina TA, et al. "Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum." Bull Exp Biol Med. 2002 Nov;134(5):448-50.
Additional preclinical studies available upon request
Quality Assurance & Analysis
HPLC Purity Analysis: Certificate of Analysis (COA) provided with every batch
Mass Spectrometry: Confirmed molecular identity verification
NMR Spectroscopy: Structural integrity validation
Elemental Analysis: C, H, N, O content verification
Stability Testing: 24-month shelf life under recommended storage conditions
Mechanism of Action
Nooglutyl exerts its effects through two primary mechanisms:
AMPA Receptor Modulation
Acts as a positive allosteric modulator of AMPA-type glutamate receptors
Enhances fast excitatory neurotransmission and synaptic plasticity
Improves memory formation and learning capabilities
Promotes neuroprotection against ischemic and hypoxic brain damage
Dopamine D2 Receptor Regulation
Modulates dopamine D2 receptor function in the striatum
Reduces anxiety and improves emotional regulation
Enhances cognitive flexibility and executive function
Potentially useful in treating certain psychiatric disorders
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Packaging & Shipping
Delivery Time:Around 3-5 workdays after your payment.
Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside
Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum
Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum
Storage:Stored in dry and cool place,keep away from strong light and heat.
Shelf Life:Two years when properly stored.
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Package |
1kg/bag ,25kg/bag;25kg/drum; customize as customer's equirements. |
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Transit |
Fedex, TNT,DHL,EMS,and so on. |
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Shipping port |
Shanghai/Tianjin/Dalian/Beijing/Xi'an |
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Lead Time |
1-2 working days upon received the payment |
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For mass orders, it will be delivered by air or sea. |
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FAQ
Q: 1. I want to know more details about the product, how can I contact you?
A: You can send us an email inquiry at any time. For more accurate quotes, I need the following information: product name, order quantity, receipt country, quality requirements, etc.
Q: 2. How do I know if your products are real or fake?
A: We will inspect every shipment. I can provide test reports including HPLC, MS and HNMR if you want. Please find a professional chemist to help you confirm the authenticity of the test report.
Of course, you can also purchase samples to take you around your trust.
Q: 3. How do you ensure the safety of the package I receive?
A: I want to receive the package safely, I first need to know your delivery address, do you have a preferred courier method, did you buy it from China?
Why do you want to know?
Because each country has different requirements for imported packages, especially chemical products, you need to know the basic information to provide you with the safest choice.
At present, we have professional customs clearance agents in EU countries, the United States, the United States, Canada, and Southeast Asia. We have professional customs clearance agents to ensure the safety of packages.
Q: 4. How to pay?
A: Our payment channels include bittoin, bank card, Western Union, Allegitudes, etc.
It is usually recommended that customers pay with Bitcoin, because the fee is low, the entry speed is fast, and the security is guaranteed.
Q: 5. How long does it take to receive the package?
A: This will vary according to the delivery method you choose. I will briefly introduce our commonly used special lines.
Usually European countries 10-15 days after sending you the tracking number.
In the United States and Canada, it usually takes 7-10 days.
Southeast Asian countries are 3-7 days.
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