| Product Name | Indomethacin |
| CAS Number | 53-86-1 |
| Molecular Formula | C₁₉H₁₆ClNO₄ |
| Appearance | White to light yellow to light orange powder or crystal |
| Molecular Weight | 357.79 g/mol |
| IUPAC Name | 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid |
| Purity | ≥98% (HPLC/Titration) |
| Solubility | Soluble in chloroform, ether, acetone, ethanol, methanol ; Insoluble (0.937 mg/L at 25°C) |
| Storage Conditions | Short-term (days–weeks): 0–4°C; Long-term (months): –20°C |
Products Description
what IS Indomethacin?
Indomethacin is a potent nonsteroidal anti-inflammatory drug (NSAID) with broad therapeutic applications. It works by inhibiting the synthesis of prostaglandins-critical mediators of inflammation, fever, and pain-through the blockade of cyclooxygenase (COX) enzyme.So It is a potent, non-selective cyclooxygenase (COX) inhibitor.
Hot Product
Applications Of Indomethacin
Indomethacin is FDA-approved for the following conditions:
| Indication | Description |
|---|---|
| Moderate to severe rheumatoid arthritis | Including acute flares of chronic disease |
| Moderate to severe ankylosing spondylitis | Inflammatory arthritis primarily affecting the axial skeleton |
| Moderate to severe osteoarthritis | Degenerative joint disease |
| Acute painful shoulder | Bursitis and/or tendinitis |
| Acute gouty arthritis | Urate crystal deposition in joints |
| Patent ductus arteriosus (IV only) | Non-cyanotic heart defect in premature infants |
Benefits of Indomethacin
Indomethacin is a potent nonsteroidal anti-inflammatory drug (NSAID) with broad therapeutic applications. Its benefits extend far beyond traditional anti-inflammatory and analgesic effects, encompassing FDA-approved indications (rheumatoid arthritis, gout, ankylosing spondylitis, osteoarthritis, bursitis, patent ductus arteriosus), emerging research applications (oncology, virology, neurology, nerve regeneration), and unique clinical utilities such as treating specific headache disorders and preventing post-ERCP pancreatitis.
1.Core Clinical Benefits (FDA-Approved Indications)
Indomethacin is FDA-approved for multiple inflammatory and pain conditions. The medication has antipyretic, anti-inflammatory, and analgesic properties that treat various conditions.
2.Neonatal Indication – Patent Ductus Arteriosus (PDA)
Indomethacin (IV formulation only) is FDA-approved for closing a patent ductus arteriosus in premature infants .
Mechanism: Prostaglandin E2 (PGE2) relaxes smooth muscle and inhibits ductus arteriosus closure. In preterm infants, relatively high PGE2 concentration prevents closure. Indomethacin aids closure by inhibiting PGE2 synthesis.
3.Distinct from Other NSAIDs
Indomethacin is unique among NSAIDs in its ability to treat specific headache disorders. In fact, a positive response to indomethacin is a defining diagnostic criterion for certain conditions.
| Headache Disorder | Benefit |
|---|---|
| Paroxysmal Hemicrania | Essential diagnostic criterion is response to therapeutic indomethacin dosage |
| Hemicrania Continua | Same diagnostic criterion applies |
| Primary Cough Headache | Indomethacin-responsive |
| Exercise Headache | Indomethacin-responsive |
| Hypnic Headache | Indomethacin-responsive |
| Headache Associated with Sexual Activity | Indomethacin-responsive |
| Stabbing Headache | Indomethacin-responsive |
| Refractory Post-COVID Headache | Preliminary evidence suggests efficacy |
Important Disclaimer
Indomethacin is an FDA-approved prescription medication. NSAIDs, including indomethacin, carry serious risks of cardiovascular thrombotic events and gastrointestinal bleeding . Use only under medical supervision for approved indications. Research-grade indomethacin is intended for research use only and not for clinical diagnostic or therapeutic purposes without appropriate regulatory authorization . Emerging applications (oncology, antiviral, neuroprotection) remain under investigation and are not FDA-approved for these indications.
Packing & Shipping
Signature Record
CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q: Can this Indomethacin product be used for both human formulations and veterinary applications?
A: Yes, our Indomethacin is suitable for a wide range of pharmaceutical applications.
Q: What is the purity level and particle size specification of your Indomethacin powder?
A: Our Indomethacin API (CAS No. 53-86-1) features a high purity assay of 98.5% to 102.0% (on a dried basis), strictly meeting USP/EP testing specifications.
Q: What are the shipping and storage conditions required for global transit of Indomethacin?
A: Indomethacin is sensitive to light. It must be stored in tight, light-resistant containers at controlled room temperature . For international transport, we use climate-controlled, light-shielded logistics. It is classified under standard chemical shipping regulations, and we handle all customs clearance documentation, including Dangerous Goods declaration if applicable in specific regions.
Q: Can you offer OEM service?
A: Yes,We supply it as an Active Pharmaceutical Ingredient (API) for human finished dosage forms (such as capsules, sustained-release tablets, suppositories, and injections). Additionally, we provide high-quality grades suitable for veterinary non-steroidal anti-inflammatory drug (NSAID) formulations.
Q: How should Indomethacin be stored?
A: For powder :Room temperature, cool and dark place, protect from light.
For Solution:Aliquot and store at -20°C; avoid repeated freeze-thaw cycles.
Hot Tags: indomethacin research, China indomethacin research manufacturers, suppliers, factory, Berberine for Blood Sugar Support, Clotrimazole Antifungal Powder Bulk, Dihydroberberine for Fat Metabolism, High Purity Pantethine, Povidone Iodine for Infection Prevention, Yohimbine Hydrochloride for Erectile Dysfunction
