| Parameter | Abacavir (Free Base) | Abacavir Sulfate |
| CAS Number | 136470-78-5 | 188062-50-2 |
| Molecular Formula | C₁₄H₁₈N₆O | C₁₄H₁₈N₆O·½H₂SO₄ |
| Molecular Weight | 286.33 g/mol | 335.35 g/mol |
| Appearance | White to off-white powder | Solid powder |
| Purity (Research Grade) | ≥98% (HPLC) | ≥98% (HPLC) |
| Melting Point | 155-161°C | - |
| Specific Rotation | -56° to -51° (c=1, MeOH) | -53.0° to -57.0° (c=0.15, MeOH) |
| Development Code | 1592U89 | 1592U89 |
| Storage Conditions | -20°C or room temperature, protected from light | Long-term stable |
| Solvent | Abacavir (Free Base) | Abacavir Sulfate |
| DMSO | 57 mg/mL (199.07 mM) | Insoluble |
| Water | Insoluble | 36-67 mg/mL |
| Ethanol | 14 mg/mL (48.89 mM) | Insoluble |
Products Description
What Is Abacavir?
Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside analogue belonging to the nucleoside reverse transcriptase inhibitor (NRTI) class of antiretroviral drugs -1-6. It is used in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children.
CAS Number (free base): 136470-78-5
CAS Number (sulfate salt): 188062-50 -2
Molecular Formula: C₁₄H₁₈N₆O
Molecular Weight: 286.33 g/mol
Development Code: 1592U89
FDA Approval Year: 1998
Available Forms:
Free base (research grade, ≥98% purity)
Sulfate salt (clinical formulation, water-soluble)
Oral solution: 20 mg/mL
Tablets: 300 mg (scored)
Applications Of Abacavir
1.Core Therapeutic Application (FDA Approved)
Primary Indication: Abacavir is indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection .
Pharmacological Class: Nucleoside analogue HIV-1 reverse transcriptase inhibitor (NRTI).
2.Research Applications (Preclinical)
Abacavir has been validated in preclinical efficacy studies using chimeric HIV-1 (EcoHIV)-infected mouse models -2:
Key Findings from Mount Sinai Study (AIDS Journal, 2007):
Dosage tested: 100 mg/kg/day.
Efficacy: 96% inhibition of viral DNA synthesis in spleen.
Effect: Almost completely abolished viral spliced RNA synthesis in spleen and macrophages.
Application Value: This mouse model system permits rapid, statistically powerful, and inexpensive evaluation of antiretroviral drugs in vivo.
3.Immunomodulatory & Other Research
1)According to research product data, Abacavir hydroxyacetate exhibits:
Anti-HIV activity (nucleoside analog reverse transcriptase inhibitor)
2)Immunomodulatory activity：
Research applications including psoriasis model studies (demonstrated reduction in skin lesions in SCID mouse models).
4.Hypersensitivity Reaction (HSR) – Critical Safety Application
Black Box Warning: Serious and sometimes fatal hypersensitivity reactions have occurred with abacavir
Key Clinical Features:
Multi-organ clinical syndrome
Usually occurs during first few weeks of therapy
Symptoms: fever, rash, nausea, vomiting, malaise/fatigue, loss of appetite, respiratory symptoms (cough, shortness of breath)
Benefits Of Abacavir
1.Effective HIV-1 Viral Load Suppression
1.1The primary benefit of Abacavir is its ability to significantly reduce the amount of HIV in the blood (viral load) when used as part of combination antiretroviral therapy.
1.2 Immune System Restoration
Abacavir helps increase the number of CD4 cells in the blood, which are essential for fighting off other infections.
| Immune Benefit | Clinical Impact |
|---|---|
| CD4 Cell Increase | Improves immune system function |
| Reduced OI Risk | Lowers chance of opportunistic infections |
| Reduced Cancer Risk | Decreases risk of HIV-related cancers |
| Improved Quality of Life | Enhances overall health outcomes |
Reducing the amount of HIV and increasing CD4 cells may reduce the risk of death or getting opportunistic infections (OIs) that can happen when the immune system is weakened.
| Benefit Category | Key Advantage | Supporting Data |
|---|---|---|
| Viral Suppression | Reduces HIV viral load | Demonstrated in treatment-naïve adults -9 |
| Immune Restoration | Increases CD4 cell count | Helps fight opportunistic infections -6 |
| Dosing Flexibility | Once-daily or twice-daily options | Noninferiority demonstrated in clinical trial -3-7 |
| Pediatric Use | Approved from 3 months of age | Weight-band dosing established -9 |
| Generic Availability | Lower cost options | PEPFAR-approved generics -6 |
| FDC Options | Simplified regimens | ABC/3TC, Triumeq combinations |
Packing & Shipping
Customer Feedback
CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q: Have you performed Nitrosamine Risk Assessment for Abacavir manufacturing?
A:Yes, a comprehensive Nitrosamine Risk Assessment has been conducted across our entire synthetic route in compliance with FDA and EMA mandates. Our process utilizes raw materials and solvents that eliminate the risk of forming nitrosamine drug substance-related impurities (NDSRIs), guaranteeing compliance for international market distribution.
Q: What are the standard packaging, storage, and retest period for your bulk Abacavir?
A: Our Abacavir Sulfate is packed in primary double-layer LDPE bags, sealed with plastic ties, and protected inside a secure cardboard outer drum. It is stable when stored below 30°C, protected from light and moisture. Under these recommended conditions, we offer a verified retest period of 36 months, ensuring exceptional shelf-life stability for international shipping.
Q: How soluble is Abacavir, and what solvents should I use?
A: For maximum solubility: Use DMSO at 100 mg/mL with ultrasonic assistance.
For aqueous solutions: Expect limited solubility (~2 mg/mL).
Storage: Stock solutions can be stored at -20°C for several months.
Q: What is the most critical safety warning for Abacavir?
A: Black Box Warning – Hypersensitivity Reactions: Abacavir can cause serious and sometimes fatal hypersensitivity reactions, typically occurring within the first 6 weeks of treatment (median onset: 9 days).
Q: What is the mechanism of action of Abacavir?
A: Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI)
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