Suzetrigine VX-548 CAS 2649467-58-1

Suzetrigine, previously known as VX-548, is a first-in-class, orally bioavailable small-molecule selective NaV1.8 inhibitor and non-opioid analgesic compound. NaV1.8 voltage-gated sodium channel mainly expresses on peripheral nociceptive sensory neurons and mediates pain signal transmission. Suzetrigine blocks NaV1.8 selectively, suppressing nociceptive signal conduction without affecting central sodium channel subtypes. It has been widely applied in preclinical and pharmacological research for acute pain, offering a novel research alternative to opioid pain agents. This product is supplied as high purity solid powder for laboratory research only, with full analytical documentation including COA, HPLC and SDS available upon request.

Suzetrigine (VX-548) is mainly used in academic and biotech laboratory research focused on non-opioid analgesic drug discovery and pain signaling study. Researchers use this compound to explore NaV1.8 channel function, peripheral nociception pathways, acute postoperative pain models and new pain therapeutic development. It serves as key reference material for sodium channel pharmacology, in-vitro cellular channel assay and animal preclinical pain evaluation. For research use only, not for human administration.

Bullet points：

1)NaV1.8 sodium channel pharmacology assay (in vitro cellular electrophysiology study)

2)Preclinical acute pain animal model research (post-surgical pain study)

3)Non-opioid analgesic new drug discovery & target validation

4)Nociceptive signal transmission mechanism research on peripheral sensory neurons

5)Reference standard for compound screening and pharmacological comparison

Our Suzetrigine (VX-548) research compound features high stereochemical purity and confirmed identity via HPLC, NMR and mass spectrometry, ensuring reliable repeatability for your in-vitro and in-vivo pain research. With high selectivity toward NaV1.8 channel and ultra-low IC50 value, it minimizes off-target activity against other sodium channel isoforms. We provide flexible packing sizes ranging from small lab samples to bulk orders, full traceable batch certificates, stable cold-chain packaging and fast global shipping. Our team supports custom quotation and technical document service for drug discovery and pharmacology research institutes.

Bullet points：

1)High target selectivity: Potent NaV1.8 inhibitor with IC50=0.7 nM, low cross reactivity with other NaV subtypes, reduces off-target interference for pain mechanism research

2)Verified stereochemistry: Absolute stereostructure confirmed, consistent batch-to-batch quality, improves experiment reproducibility

3)Complete QC documentation: COA, HPLC, NMR, MS, SDS supplied for each batch, meets institute procurement & lab audit requirements

4)Flexible packaging: Multiple packing sizes from mg-scale sample to bulk quantity, suitable for early-stage screening & preclinical study

5)Professional cold-protected packaging: Light & moisture sealed packaging to preserve chemical stability during international shipment

6)Technical support available: We support custom order and technical consultation for drug discovery research teams

Bullet points:

Pack form: Amber glass vial, vacuum sealing, light & moisture barrier protection

Shipping condition: Cold shipment (ice pack / dry ice for large bulk)

Storage requirement after receive: Store at -20°C, avoid light and humidity

Shelf life: 3 years when stored properly as powder

Shipping service: Global delivery, tracking number provided, customs document support

If you want to buy high purity Suzetrigine (VX-548) CAS 2649467-58-1 for your lab research, please contact our sales team directly. We offer lab sample and bulk quantity quotation, and all batches come with full COA and analytical documents. Send your inquiry with required quantity to our email, our specialist will reply with quotation, lead time and shipping details quickly.

1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106

Online instant messaging

2.Contact Information：
Name：Alice

Telephone :+8618509260106
Email:alice@xaheshun.com

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