Loratadine Effects & Side Effects Guide

Loratadine is a second-generation antihistamine drug. It is highly selective for peripheral nerve H1 receptors and has a long-lasting effect. Compared with first-generation antihistamine drugs such as astemizole, loratadine has no obvious drowsiness effect.
Loratadine was launched in 1988 and quickly became the world's best-selling antihistamine. It was approved by the FDA as an over-the-counter drug in 2002.

1.Widely used for allergy symptoms

Loratadine can relieve systemic symptoms caused by various allergic reactions, allergic rhinitis, skin allergies, seasonal pollen allergies, drugs or food allergies.

2.Anti-inflammatory

It is mainly involved in the auxiliary anti-inflammatory effect. In allergic diseases (such as urticaria, rhinitis), it can reduce edema and itching, inhibit the release of potential anti-inflammatory factors, and synergistically inhibit chronic inflammation, but it is not the main role.

3.Safety and long-term efficacy

Compared with first-generation antihistamines (such as chlorpheniramine), loratadine has less effect on the central nervous system and does not cause obvious drowsiness. If headache or dry mouth occurs, you can stop taking the drug and it will be relieved on its own.

Loratadine is taken after a single oral dose and only needs to be taken once a day. The effect can last for 24 hours, and the metabolite descarboxyethoxyloratadine is still active.

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1.Common mild side effects

As a second-generation antihistamine, loratadine has a relatively high overall safety, but its potential side effects still need to be paid attention to.

2. Risks for special groups

Pregnant women, lactating women, the elderly and those with impaired liver and kidney function.

1)Pregnant women, breastfeeding women, and those with impaired liver and kidney function should use it with caution and follow the doctor's advice

2)Elderly people should be careful not to use it with antiarrhythmic drugs, as it may cause palpitations.

Recommended dosage: Especially for patients with a history of heart disease, you can take 5 mg at a time, and monitor your electrocardiogram at all times.

3)Children aged 2 to 12 years old should use syrup, which is easy to control the amount of consumption. After taking it, monitor whether the child is overexcited or sleepy.

1.It is recommended not to take it continuously for more than 2-4 weeks. If you need to use it for a long time, you must follow the doctor's advice.

2.Avoid using with ketoconazole, erythromycin and other liver enzyme inhibitors, as this may aggravate the side effects.

1.Loratadine: A non-sedating antihistamine. Review of its effects on histamine-induced wheal, flare, and pruritus.

Annals of Allergy, Asthma & Immunology (1994)

2.Pharmacokinetics and pharmacodynamics of loratadine in children with seasonal allergic rhinitis.

Clinical Pharmacology & Therapeutics (2001)

3.Anti-inflammatory effects of loratadine on human eosinophils.

International Archives of Allergy and Immunology (2002)

4.Cardiac safety of second-generation antihistamines.

American Journal of Rhinology & Allergy (2013)

5.U.S. Food and Drug Administration (FDA) LORATADINE- loratadine tablet