Nicotinamide Riboside Chloride: Benefits, Side Effects and Dosage

Product name: Nicotinamide riboside chloride
Other Names: NR-CL
CAS: 23111-00-4
Purity: ≥60%, ≥98%
MF: C11H15N2O5.Cl
MW: 290.7002

Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride which is a nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3,culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.

1.Improvement of energy metabolism

Nicotinamide Riboside Chloride can control the proper digestion and absorption of protein and fat.Nicotinamide riboside promotes oxidative phosphorylation reactions in energy metabolism processes by activating an enzyme called NAD+ within cells. NAD+ is an important coenzyme and plays a key role in energy metabolism. Research has found that the supplementation of nicotinamide ribose can increase the content of NAD+ within cells, thereby promoting the function of mitochondria and the efficiency of energy production. This property makes nicotinamide riboside a potential adjunctive treatment for improving energy metabolism, and it is expected to be used in the treatment of some metabolic diseases, such as obesity and diabetes.

2.Protection of cardiovascular health

Nicotinamide Riboside Chloride can prevent skin diseases.Nicotinamide riboside is also believed to have a protective effect on cardiovascular health. Studies have shown that supplementation with nicotinamide riboside can reduce the risk of cardiovascular diseases and improve some indicators during the course of the disease. One of the important mechanisms of action is through activating the expression of the SIRT1 protein

Play a protective role. SIRT1 is a protein capable of regulating a variety of biological processes within cells, including oxidative stress, inflammatory responses, and apoptosis. Research has found that the supplementation of nicotinamide riboside can increase the expression of SIRT1, thereby protecting the health of the cardiovascular system.

3.The effect of delaying aging

Nicotinamide Riboside Chloride promote the nucleic acid Synthesis, to prevent the aging of tissues and organs.The supplementation of nicotinamide ribose also shows potential effects in delaying aging. Research has found that the supplementation of nicotinamide riboside can enhance the efficiency of DNA repair, reduce the accumulation of DNA damage within cells, and thereby delay the aging process of cells. In addition, nicotinamide riboside can also affect the function of mitochondria and reduce mitochondrial damage caused by oxidative stress, further delaying the aging process of cells and tissues.

4.Other possible functions

In addition to the main functions and effects mentioned above, nicotinamide riboside is also believed to have some other possible functions. For instance, research has found that supplementation with nicotinamide riboside can alleviate fatigue and enhance daily energy and vitality. In addition, nicotinamide riboside also shows certain anti-inflammatory effects, which can alleviate inflammatory responses and pain. These additional effects provide more possibilities for the clinical application of nicotinamide ribose.

Aging is linked to low levels of NAD+, your body needs optimal levels of NAD+ to maintain a healthy body and mind. Nicotinamide Mononucleotide help to boost NAD+, repair damage of the DNA and prolong your youth. Low levels of NAD+ in the body results in feeling tired and groggy. Other benefits of Nicotinamide Mononucleotide are enhance physical performance and brain funtions.

Our Nicotinamide Mononucleotide powder is the rawest form of Nicotinamide Mononucleotide and is what most companies are using to create their Nicotinamide Mononucleotide products.

As a dietary supplement, take 300mg to 400mg daily with meals, or as directed by physician. Do not exceed the recommended dosage.

NMN Powder Puts You In Control. Mix it with yogurt or water, take it raw, or even though not required, take it as a sublingual. The choice is yours.

Daily Health Maintenance: 250-500mg per day, taken 1-2 times after meals (to enhance absorption rate).
Disease Adjuvant Therapy: 500-1000mg per day. It should be used under the guidance of a doctor (such as for metabolic syndrome and neurodegenerative diseases).
Maximum Tolerated Dose: No serious side effects were reported when 2000mg/ day was used in the short term in clinical trials, but its long-term safety remains to be verified.

Gastrointestinal discomfort: such as nausea and abdominal distension (incidence rate about 5%-10%, usually mild and transient).

Headache or fatigue: It may be related to the regulation of NAD+ metabolism and mostly occurs in the initial stage.

High-dose elevated liver enzymes: A very small number of cases have reported long-term high-dose (>2000mg/ day) leading to elevated ALT/AST, which recovered after drug withdrawal.

Cancer risk controversy: NAD+ may promote the metabolism of cancer cells, but there is no clear human evidence yet. Cancer patients should use it with caution.

Pregnant women/lactating women: Insufficient safety data. It is recommended to avoid use.

Patients with autoimmune diseases: Theoretically, there is a risk of immune activation (such as systemic lupus erythematosus).

https://wenku.so.com/d/ee155949cdd5122eb2726eb7a6dc545d

https://www.chemicalbook.com/NewsInfo_15014.htm

https://www.sohu.com/a/820158696_121931847?scm=10001.325_13-109000.0.0.5_32