What are the effects of Nuciferine?

‌Nuciferine is an alkaloid found mainly in the Nymphaea caerulea and Lotus Leaf plants. Nuciferine is an important natural organic substance. Through its special alkaline chemical formula, it can achieve antioxidant effects and improve the flavor and nutrition of food. Therefore, Nuciferine has many important pharmacological effects.

The lotus leaf line provided by Xi 'an Tongze Biology is derived from the lotus leaf, the extracted content is 1%, 2%, 10%, 98%, 98% is the highest purity, the color is white powder. High-purity nuciferine is beige to off-white crystalline powder. The higher the purity, the lighter the color.

1.Regulating metabolism

Reducing dietary fat absorption by inhibiting pancreatic lipase activity. At the same time, it can accelerate the oxidation of fatty acids and reduce fat accumulation.

Taking health supplements containing lotus leaf alkaloids within 30 minutes after meals can effectively manage fat and control weight.

If your blood lipids and blood sugar are abnormal, you can take products containing Nuciferine which needs to be taken together with oatmeal, a food rich in dietary fiber. The content of Nuciferine is 20-40mg/day. After taking it, you need to do aerobic exercise to reduce serum triglyceride and cholesterol levels and assist in weight loss.

2.Antioxidant

Reduce oxidative stress damage by clearing free radicals. If exposed to long-term UV damage, staying up late and insomnia may be a problem. Drinking tea containing low concentrations of lotus leaf alkaloids at night can alleviate insomnia symptoms. With the facial mask containing lotus leaf alkaloid, it can effectively improve the skin from UV damage.

3.Anti-inflammatory

It can alleviate chronic inflammation by inhibiting the expression of NF - κ B, vascular endothelial inflammatory factors .Other inflammatory factors, especially in patients with fatty liver and mild atherosclerosis.

4.Protecting cardiovascular health

By inhibiting excessive platelet aggregation, the risk of venous thrombosis is reduced. Suitable for people who sit for a long time or need high concentration, they can regularly take health products containing lotus leaf alkaloids, and should not be taken together with blood pressure lowering. If your blood pressure is ≥160/100 mmHg, you must seek medical attention and take medication promptly. Because health products containing lotus leaf alkaloids only have the effect of assisting in lowering blood pressure and cannot control hypertension.

1.Common side-effects

Common symptoms include abdominal pain, diarrhea, nausea, and vomiting, which often occur in patients with gastritis/irritable bowel syndrome, as well as those who take lotus leaf alkaloid capsules or high concentration lotus leaf tea on an empty stomach.

If you experience symptoms such as dizziness, fatigue, and darkening of the eyes, you may be a patient with low blood pressure or have used antihypertensive drugs in combination.

2.Special population risk

Pregnant women, breastfeeding women, and children under 12 years old are prohibited from using any form of lotus leaf products. For patients with renal insufficiency, if taking lotus leaf alkaloid products, there may be obstruction of alkaloid excretion, exacerbating kidney damage. It is necessary to reduce the use or follow medical advice.

1.Do not use in combination with antihypertensive drugs, anticoagulants, or sedatives.

2.For Nuciferine health products, the recommended dosage is Nuciferine ≤50mg/day, and it cannot be taken on an empty stomach.

3.Patients with chronic diseases should follow medical advice. Use for no more than 6 months per year.

1.Guo F. et al. (2016). Nuciferine prevents hepatic steatosis by suppressing lipogenesis via AMPK activation. Journal of Agricultural and Food Chemistry, 64(22), 5063-5071.

2.Du H. et al. (2010). Nuciferine inhibits LPS-induced inflammatory response by suppressing NF-κB pathways in macrophages. Biochemical Pharmacology, 79(4), 998-1004.

3.Zhang Y. et al. (2015). Vasodilatory effects of nuciferine in rat aortic rings: Role of calcium channels. European Journal of Pharmacology, 768, 21-28.

4.Case Report: Wang L. et al. (2017). Symptomatic hypotension induced by lotus leaf tea in a hypertensive patient. Journal of Alternative and Complementary Medicine, 23(9), 718-720.

5.Farzin D. & Mansouri N. (2006). Antidepressant-like effect of nuciferine in forced swim test: Involvement of serotonin receptors. Life Sciences, 79(25), 2473-2478.