What is Tianeptine Sodium Salt?

Tianeptine sodium salt is a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Tianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines. Tianeptine (INN) (Stablon, Coaxil, Tatinol) is a SSRE drug used for treating major depressive episodes (mild, moderate, or severe). Tianeptine commonly used for depression. It is also used for pain, asthma, anxiety, and many other conditions, but there is no good scientific evidence to support these other uses.

Tianeptine sodium salt is a tricyclic antidepressant. Its antidepressant mechanism is different from that of traditional tricyclic antidepressants. It can increase the reuptake of 5-HT in the synaptic cleft and may have the effect of improving the conduction of 5-HT neurons. It has no affinity for choline or epinephrine receptors. The antidepressant efficacy is similar to that of tricyclic compounds, but the tolerance is better than that of tricyclic compounds. In animal experiments, it can increase the spontaneous activity of pyramidal cells in the hippocampus and accelerate the recovery of their functions after inhibition. Chemicalbook can enhance the reabsorption of serotonin by neurons in the cerebral cortex and hippocampus. Teneeptin sodium is absorbed rapidly and completely in the digestive tract. It is distributed rapidly, with a PPB as high as 94%. It is completely metabolized in the liver through β -oxidation and N-demethylation. The terminal clearance T1/2 is short, which is 2.5 hours. A very small amount of the original drug (8%) is excreted through the kidneys, mainly its metabolites are excreted through urine. The clearance of T1/2 in patients with renal insufficiency is prolonged for 1 hour.

It is used for the treatment of mild, moderate or severe depression, neurogenic and reactive depression, anxiety and depression caused by physical discomfort, especially gastrointestinal discomfort, and anxiety and depression that occur in alcohol-dependent patients during the withdrawal process. The recommended dose is 12.5mg orally before the main meals of breakfast, lunch and dinner in Chemicalbook, tid. For those with chronic alcoholism, regardless of whether they have liver cirrhosis or not, there is no need to adjust the dosage. For patients over 70 years old and those with renal insufficiency, the dosage is limited to 2 tablets per day.

Common symptoms include dry mouth, nausea, drowsiness, dizziness, headache, insomnia, nightmares, weight gain and constipation. Rare myalgia, back pain, ventricular arrhythmia, orthoorthotic hypotension, palpitations, bradycardia, tremors, anxiety, irritability, hot flashes, facial flushing, bitter taste in the mouth, flatulence, abdominal pain, elevated serum alanine aminotransferase, rash, etc.

1.Use with caution in patients with cardiovascular diseases, gastrointestinal diseases, and severe renal insufficiency.

2.Depressed patients with hereditary suicidal tendencies must be closely monitored when taking this medicine, especially at the beginning of the treatment. 3. If general anesthesia is required, the anesthesiologist should be informed that the patient is taking this medicine and the medication should be stopped 24 or 48 hours before the operation.

3.When emergency surgery is required, there may not be a necessary drug withdrawal period, but preoperative monitoring should be conducted.

4.As with all medications for treating mental disorders, if treatment is interrupted, the dosage should be gradually reduced for more than 7 to 14 days.

5.Some patients may experience a decline in alertness. Drivers or operators of Chemicalbook machines should be aware of the risk of drowsiness when taking this medicine.

6.Before starting treatment with this product, monoamine oxidase inhibitor drugs must be discontinued for 2 weeks. For patients who were originally taking this product and were treated with monoamine oxidase inhibitor drugs, they only need to stop taking this product for 24 hours.

7.Animal experiments have shown that this drug has no adverse effects on reproductive function. Only a very small amount of the drug passes through the placenta, and no accumulation effect in the fetus has been observed. However, there are no relevant clinical research data on humans. This medicine should be avoided during pregnancy.

8. Tricyclic antidepressants can be secreted into breast milk. It is recommended not to breastfeed during the medication period.

McEwen, B. S., et al. (2010)
Mechanism of action of tianeptine: A novel atypical antidepressant.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(7), 1097-1102.
DOI: 10.1016/j.pnpbp.2010.05.021

Kasper, S., & McEwen, B. S. (2008)
Neurobiological and clinical effects of the antidepressant tianeptine.
CNS Drugs, 22(1), 15-26.
DOI: 10.2165/00023210-200822010-00002

Wagstaff, A. J., et al. (2001)
Tianeptine: A review of its use in depressive disorders.
CNS Drugs, 15(3), 231-259.
DOI: 10.2165/00023210-200115030-00006