What is L-ergothioneine good for?

1)A naturally occurring rare amino acid, usually biosynthesized by bacteria and fungi, first isolated from the fungus Claviceps purpure in 1909. It was later found to be present in human tissues and organs. It acts as a protective agent and antioxidant for cells in the human body.

But our bodies can't make it themselves and must get it from the outside world, so eating mushrooms is thought to increase the level of ergothioneine in the body.

2)For natural source

It is extract from the mushroom.The specification of L-ergothioneine can be reach 0.5%-1%.L-ergothioneine powder is a natural antioxidant, which can protect cells in human body and is an important active substance in the body.

Compared to vitamin C and glutathione, two old-school antioxidants, ergothioneine is safer, gentler, more stable, and has stronger antioxidant power.

1.Super antioxidant capacity

Directly eliminate free radicals (such as hydroxyl radicals and peroxynitrite), protect cells from oxidative damage, while stabilizing other antioxidants like glutathione and prolonging its action time. Therefore, ergot sulfur is not easily metabolized and consumed, and can exist in cells for a long time, exerting strong antioxidant capacity.

Therefore, the health product industry takes advantage of this by adding it to beverages, energy bars, and capsules to enhance antioxidant capacity. Targeting populations with high antioxidant needs, such as the elderly, chronic disease patients, or those who lack mushrooms in their diet.

2.Protecting cells and anti-inflammatory effects

By reducing the production of inflammatory factors, chronic inflammation can be alleviated. Simultaneously protecting mitochondrial function and maintaining cellular energy metabolism efficiency.

It can combined with physical/chemical sunscreen agents to enhance anti photoaging effects and reduce UV induced DNA damage in skin cells. Used for repairing skincare products after sun exposure.

3.Anti-aging

By delaying the progression of cellular aging markers, we can inhibit the degradation of skin collagen and elastin fibers, thereby reducing wrinkles. It is often added to anti-aging skin care products such as essence and face cream. The representative products are Elizabeth Arden's "Orange" series and Estee Lauder's high-energy small brown bottle.

4.neuroprotection

By penetrating the blood-brain barrier, it protects neurons from oxidative damage. For potential neurodegenerative diseases, the risk of this disease can be reduced.

5.Support mitochondrial health

Mitochondria are the main targets of many drug toxicity reactions, and the physiological function and homeostasis of cells are closely related to the functional health of mitochondria to a large extent.

When mitochondria are injured, ROS produced by them cannot be effectively removed, which will lead to a malignant positive feedback mechanism, exacerbating the damage of mitochondria and cells until the loss of cell function or apoptosis occurs.

L-Ergothioneine has a protective effect on mitochondria, which can resist damage caused by natural, disease processes or exogenous factors.

1.Different forms of suggestions

1)Oral supplements, such as capsules, gummies, and drops, should be taken with meals or in combination with low-fat foods such as milk and nuts.

2)If it is a skincare product, it can be used in the morning and evening, and daytime use can better exert anti-aging effects. At the same time, combined with sunscreen, it has a better effect.

3)For exercise supplements, it is necessary to take them one hour before exercise to reduce oxidative damage during exercise; Or take it with a recovery meal after exercise.

2.special populations

1) For those with gastrointestinal sensitivity, it is recommended to take it with meals first or choose a liposome encapsulated formulation to reduce irritation to the gastrointestinal tract.

2) The elderly or those who are not well absorbed can take it together with foods rich in mushrooms, such as oatmeal and mushroom Congee, which can improve the utilization rate

Summary: It can be taken once a day at a fixed time, without the need for segmented supplementation like vitamin C. The daily dosage is 3-10mg, not exceeding 30mg.Taking it with breakfast or Lunch at the same time and pairing it with a small amount of fat is the best choice.

Ergothioneine (EGT) has high safety, with very few and mild side effects. Common effects include gastrointestinal discomfort, mild nausea, and bloating. People who are allergic to fungal products may experience rash and itching.

For special populations such as pregnant/lactating women, those with autoimmune diseases, and those with severe renal insufficiency, it is necessary to follow medical advice.

1.Safety of Synthetic L-Ergothioneine (ERGONOVA®) as a Novel Food (2021)

2.Ergothioneine Attenuates Exercise-Induced Oxidative Stress and Muscle Damage Redox Biology (2020)

3.Ergothioneine in Skin Protection: Molecular Mechanisms and Cosmetic Applications Cosmetics (2022)

4.Ergothioneine, a Unique Antioxidant: Cellular Distribution and Metabolic Pathways Free Radical Biology and Medicine (2012)

5.Ergothioneine Levels in Alzheimer's Disease Patients: A Possible Link to Cognitive Function Journal of Alzheimer's Disease (2020)