What is the best form of spermidine to take?

Spermidine is a naturally occurring polyamine compound. It is mainly found in natural foods such as wheat germ and beans, and can also be synthesized by the human body. Xi'an Tongze Biological can provide below specifications,welcome to consult!

The best form can be explained according to its form in various fields and the way people can accept it most. The following content will explain this in detail.

1.It has anti-aging effects. It maintains cell stability by removing "garbage" such as aging proteins and damaged mitochondria in cells, thereby delaying skin cell aging and reducing wrinkle formation. This effect can be better reflected in dietary supplements and anti-aging skin care products.

It is often added to dietary supplements in capsules, tablets, oral liquids, and powders compounded with zinc and vitamins, and is widely accepted by people.

In skin care products, it can reduce wrinkles by stimulating fibroblasts to synthesize collagen. It is added to essences and creams at a concentration of 0.1%-1%.

2.It's neuroprotective effect can reduce the risk of neurodegenerative diseases by inhibiting neuroinflammation, reducing excessive activation of microglia, promoting the expression of memory-related proteins, enhancing synaptic plasticity, and improving cognitive function. This effect can be better reflected in prescription drugs, and it is necessary to follow the doctor's advice when taking it.

3.It can protect cardiovascular health, improve cardiovascular elasticity and reduce the risk of arteriosclerosis by regulating the nitric oxide pathway. It is compounded with fish oil, coenzyme Q10, etc. to make soft capsules as a vascular protection preparation.This vascular protective agent is widely used in the elderly population.

4.It can regulate metabolism, activate the AMPK pathway, enhance mitochondrial fatty acid oxidation capacity, and thus promote fat metabolism. Adding it to high-fiber cereal meal replacement products can achieve both metabolic regulation and satiety. It is very popular in the Japanese market.

5.In sports science, it can enhance physical fitness. By improving mitochondrial function, it can prolong exercise endurance. It can also reduce muscle damage and accelerate lactic acid clearance during exercise. It is often compounded with creatine and beta-alanine to make endurance enhancers suitable for marathon runners.

Spermidine has various applications, covering health care, disease prevention, functional products and other fields. When choosing, you need to choose according to your own requirement.

1.Common side effects include nausea, bloating, diarrhea, and metabolic abnormalities in patients with liver dysfunction or urea cycle disorders. Long-term high-dose use may interfere with endogenous polyamine balance.

2.Potential risks for special groups, including cancer patients or high-risk groups, pregnant and lactating women, and patients with kidney disease, all of whom may face unpredictable risks. These groups should follow the doctor's advice when using this product.

1.Eisenberg, T., et al. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, 22(12), 1428-1438.

2.Wirth, A., et al. (2018). Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease model. Journal of Neuroinflammation, 15(1), 172.

3.Nowotarski, S. L., et al. (2013). Polyamines in cancer: implications for chemotherapy. Biochemical Journal, 473(14), 2247-2261.

4.Jing, Y. H., et al. (2021). Spermidine improves insulin sensitivity in high-fat diet-induced obese mice. Diabetes, 70(3), 589-602.

5.Schwarz, C., et al. (2018). Spermidine intake is associated with reduced mortality in humans. Aging Cell, 17(1), e12715.