| Product Name | 6-Paradol |
| UNII | BO24ID7E9U |
| Source | Zingiber officinale and Aframomum melegueta |
| Appearance | White or off-white powder |
| Purity | 99% by HPLC |
| CAS Number | 27113-22-0 |
| Molecular formula | C₁₇H₂₆O₃ |
| Solubility | The predicted value is lower, about 0.011 g/L |
| Storage | Low temperature, dry, protected from light and sealed. Because it is a phenolic compound that is waxy solid at room temperature and has certain biological activity, it is easily oxidized or degraded if not stored properly. |
| Long-term storage needs to be sealed and protected from light at -20°C. Solid powder is the most reliable method and the best choice. |
Products Description
What is 6-Paradol?
6-Paradol (6-gingerol) is a natural phenolic compound found in plants of the Zingiberaceae family. It is also one of the key pungent flavors and bioactive components of ginger. It has multiple anti-inflammatory, anti-tumor, antioxidant and neuroprotective activities. It is not only an important member of the gingerol family, but also a potential tool molecule for studying COX-2 inhibition, AKT/mTOR signaling pathway and neuroinflammation. Because its structural stability and bioavailability are superior to other gingerol analogues, 6-Paradol has good application prospects in the field of functional food and drug development.
Natural sources and production processes
6-Paradol occurs naturally in Zingiber officinale and Aframomum melegueta.
In ginger, 6-Paradol belongs to the "gingerol" family, and its production pathway is:6-gingerol (6-gingerol) → (heating/dehydration) → 6-shogaol (6-shogaol) → (hydrogenation) → 6-paradol
Therefore, 6-Paradol is considered to be an important active ingredient produced after ginger is processed or metabolized in the body.
Application of 6-Paradol
According to the latest research literature, the application of 6-Paradol is mainly concentrated in three core areas: clinical treatment and food and cosmetic additives
1.Clinical treatment
Mainly reflected in the treatment of neurodegenerative diseases and adjuvant tumor treatment.
Neuroprotection and treatment of central nervous system diseases are currently the most cutting-edge application research directions of 6-Paradol. Multiple studies published in 2025 confirmed its potential in treating Parkinson's disease (PD) and cerebral ischemia.
In the field of oncology, the main application direction of 6-Paradol is not direct killing, but as an auxiliary sensitizer to reverse the drug resistance of cancer cells.
2. Cosmetic raw materials
Added to cosmetics, it is mainly used in cosmetic products containing unsaturated fatty acids (such as fish oil, nut oil, and skin care products) that are prone to rancidity and produce an unpleasant "hala smell." , low concentrations of 6-Paradol (0.0001% to 1% by weight) can serve as an efficient natural stabilizer.
3.6-Paradol is the main pungent ingredient in Aframomum melegueta and ginger and is used as a seasoning. Extracts standardized to 12.5% 6-Paradol content are already on the market for use in dietary supplements, functional foods and flavored beverages.
Benefits Of 6-Paradol
| Primary Benefit | Key Mechanism / Effect | Application Scenario |
|---|---|---|
| Metabolic Health | Activates AMPK; promotes glucose uptake; lowers blood glucose, cholesterol, and body weight in animal models. | Adjunctive support for controlling blood sugar and weight in metabolic syndrome or T2D risk. |
| Neuroprotection | Suppresses neuroinflammation & necroptosis; protects mitochondria; effects comparable to L-dopa. | Adjunctive treatment/prevention research for Parkinson's disease. |
| Adjuvant Anti-Cancer | Inhibits P-gp efflux pump; increases chemotherapy (Sorafenib) accumulation in cancer cells. | Adjuvant therapy for colorectal cancer, especially for addressing drug resistance. |
| Food Preservation | Prolongs oil oxidation induction time; slows rancidity. | Production/storage of oils and fat-rich foods as a natural preservative. |
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CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
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2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q1: What is the botanical source of your 6-Paradol, and is it naturally derived?
A: Our 6-Paradol is primarily extracted from Grains of Paradise (Aframomum melegueta). We ensure a 100% botanical origin through advanced
Q2 :What are the primary mechanisms of 6-Paradol in weight management?
A: 6-Paradol is a non-stimulant thermogenic agent. It works by activating Brown Adipose Tissue (BAT) and increasing whole-body energy expenditure through the TRPV1 receptor pathway. This allows for fat loss without the "jitters" associated with caffeine.
Q3:What is the stability and shelf life of 6-Paradol powder?
A: 6-Paradol is sensitive to light and heat. Our standardized powder is stable for 24 months when stored in a cool, dry place in its original sealed packaging. We use opaque, vacuum-sealed aluminum foil bags to prevent degradation during international shipping.
Q4:Can 6-Paradol be formulated into different dosage forms like capsules or liquids?
A: We offer both highly concentrated oils and standardized powders. Our powder form is optimized for flowability, making it ideal for encapsulation and tableting. For liquid shots, we provide water-dispersible options.
Q5：What is the MOQ (Minimum Order Quantity) and Lead Time for international air freight?
A: Our standard MOQ is 1kg-5kg for trial orders. For bulk orders (25kg+), the typical lead time is 5-7 working days from payment to dispatch. We provide full documentation for customs clearance (Commercial Invoice, Packing List, CoA, SDS).
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