Icatibant Acetate HOE-140

Icatibant Acetate, also known as HOE-140 Acetate with CAS number 138614-30-9, is a synthetic decapeptide. It acts as a highly selective, competitive antagonist of the bradykinin B2 receptor. Bradykinin B2 receptor activation triggers inflammatory responses, vasodilation and increased vascular permeability, so Icatibant Acetate is widely used in preclinical research focused on hereditary angioedema (HAE), inflammation, vascular permeability and related pharmacology studies. Supplied as white to off-white amorphous powder, this research peptide is manufactured with strict peptide synthesis and purification processes, delivering stable biological activity and high purity (≥98% by RP-HPLC). It is soluble in water and DMSO, and requires storage at -20°C away from light to prevent peptide degradation.

These similar peptides and receptor modulators are frequently used alongside Icatibant Acetate in hereditary angioedema, inflammation and vascular permeability preclinical research. Researchers often select these compounds for control groups, SAR studies and pathway validation experiments.

1.Preclinical research of hereditary angioedema (HAE), exploring bradykinin-induced edema pathology

2.In vitro & in vivo pharmacology studies for bradykinin B2 receptor signalling pathway

3.Evaluation of vascular permeability, endothelial barrier function and vasodilation

4.Mechanism research of acute inflammation and bradykinin-related pain models

5.Functional assay tool compound for screening B2 receptor modulators

Icatibant Acetate (HOE-140) stands out as a high-performance tool peptide for bradykinin pathway and inflammatory pharmacology research. As a synthetic decapeptide with precise amino acid sequencing, it delivers highly selective and competitive antagonism against the bradykinin B2 receptor, with negligible binding activity to B1 receptors and other off-target targets, ensuring accurate and reliable experimental data. Purified to ≥98% RP-HPLC purity, the product effectively eliminates impurity interference that may affect cell assays and animal model experiments. With stable chemical properties and excellent water solubility, it is easy to prepare homogeneous experimental solutions for in vitro cell tests, isolated tissue experiments and in vivo preclinical studies. Featuring stable batch consistency and retained biological activity, this research-grade peptide guarantees excellent experimental repeatability, making it a reliable standard tool compound for hereditary angioedema (HAE), vascular permeability and inflammatory mechanism research.

Vacuum Sealed Lyophilized Packaging: Independent sterile vial packaging, moisture-proof, light-blocking and anti-oxidation to protect peptide bioactivity

Flexible Lab-Grade Specifications: Multiple sizes available including 10 mg, 50 mg, 100 mg and custom small-batch packaging for diverse research scenarios

Low-Temperature Dry Ice Shipping: Strict cold-chain transportation stabilizes peptide structure and avoids activity loss during long-distance shipping

Export-Grade Protective Package: Shockproof and pressure-resistant outer packaging prevents damage during international logistics

Store unopened Icatibant Acetate lyophilized powder at -20°C under sealed, dry and dark conditions. Avoid frequent temperature changes and repeated freeze-thaw cycles. After reconstitution, aliquot the solution and store at -80°C for long-term use to maintain stable experimental performance.

Disclaimer: For laboratory pre-clinical research only. Not for human clinical use, medical treatment or commercial medication.

You may order research-grade Icatibant Acetate directly through our website or contact us via the methods listed below. Submit your request via the inquiry form, state your required quantity and research purpose, and our sales team will send the quotation and delivery details quickly. Samples and custom small batch sizes are available for preclinical research projects.

1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106

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2.Contact Information：
Name：Alice

Telephone :+8618509260106
Email:alice@xaheshun.com

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