|
Product Name |
Leuprorelin |
|
Appearance |
White to off-white crystalline powder |
|
Assay |
99% by HPLC |
|
Molecular Formula |
C59H84N16O12 |
|
CAS Number |
53714-56-0 |
|
Solubility |
Easy soluble in organic solvents (e.g., DMSO, ethanol). Low solubility in aqueous solutions; typically requires preparation of stock solutions in DMSO. |
|
Storage |
Cool dry place( Store at -20°C, away from the light) Wear appropriate personal protective equipment during operation to avoid inhalation or direct skin contact. |
Products Description
What is Leuprorelin API?
Leuprorelin Acetate is a synthetic gonadotropin-releasing hormone (GnRH) analogue and a GnRH agonist. Its chemical structure significantly enhances the biological activity and stability and extends the half-life by replacing the 6th amino acid (glycine is replaced by D-leucine) and the 10th amino acid (glycinamide is replaced by acetamide) of natural GnRH.
Xi 'an Tongze can provide other peptide products, the catalog is as follows, welcome to consult!
|
Product Name |
CAS No. |
|
Goralatide |
127103-11-1/120081-14-3 |
|
ARA-290(Cibinetide) |
1208243-50-8 |
|
N-acetyl Semax Amidate |
2920938-90-3 |
|
N-AC-selank-amidate |
N/A |
|
Aviptadil Acetate |
40077-57-4 |
|
GLP-1(1-37) |
87805-34-3 |
|
GIP (huMan) |
100040-31-1 |
|
N-Acetyl-Semax |
N/A |
|
N-Acetyl Selank |
N/A |
|
S-Phenylacetyl Larazotide |
N/A |
|
Dermorphin |
77614-16-5 |
|
PEG-MGF |
N/A |
|
Met-enkephalin |
58569-55-4 |
|
Pramlintide Acetate |
196078-30-5 |
|
Dalargin |
81733-79-1 |
|
Abaloparatide |
247062-33-5 |
|
N-Acetyl Larazotide |
N/A |
|
Humanin |
330936-69-1 |
|
Adamax |
N/A |
Storage & Handling OF Leuprorelin API
Shipping Control: "All Goserelin Acetate orders are shipped via Cold Chain (Dry ice or Blue ice) with temperature monitoring to ensure potency."
Stability Testing: "Our stability data shows that the purity remains >99% after 24 months of storage at -20°C."
Packaging: "Triple-layer protection: Vacuum-sealed aluminum foil bags with desiccants inside."
Applications of Leuprorelin API
The core application of this product is mainly clinical application (Therapeutic Domains), which is specifically reflected in the following fields:
1.Oncology: Prostate Cancer: Palliative treatment of advanced prostate cancer, or in combination with radiotherapy/anti-android therapy in locally advanced cases.
2.Breast Cancer: For the treatment of advanced breast cancer in premenopausal and perimenopausal women.
3.Gynecology-Endometriosis: Reduce pain and reduce damage.
Uterine Fibroids: Reduce the size of fibroids and improve anemia before surgery.
Endometrial Thinning: Pretreatment before endometrial ablation.
4..Assisted Reproduction: Used for pituitary downregulation during controlled ovarian stimulation.
benefit of Leuprorelin API
1.Precise hormone regulation: As a powerful GnRH agonist, it can quickly reduce male testosterone or female estrogen levels to castrate levels (Castrate levels) through pituitary desensitization.
2. Multiple indications covered: * Tumor fields: advanced prostate cancer (palliative care), premenopausal breast cancer.
3. Gynecology field: The only widely recognized gold standard drug for endometriosis pain relief and preoperative reduction of uterine fibroids.
4. Rapid onset of action: Hormone levels usually reach stable suppression within 2-4 weeks after administration.
Adverse reactions - mainly due to low sex hormone status:
Men: hot flashes, loss of libido, erectile dysfunction, osteoporosis (long-term use), injection site pain.
Women: hot flashes, vaginal dryness, mood swings, decreased bone density (monitoring required after treatment for more than 6 months).
Initial "ignition" effect: It may aggravate symptoms (such as bone pain, spinal cord compression, uterine bleeding), so patients with prostate cancer can be combined with anti-androgens (such as bicalutamide) for 7-14 days in the early stage of treatment; in patients with endometriosis or uterine fibroids, the ignition effect may cause short-term pelvic pain or increased bleeding.
Long-term risks: Osteoporosis, risk of cardiovascular events may be slightly increased.
Why Choose our Leuprorelin API?
Beyond being a potent GnRH agonist for oncology, our Goserelin Acetate stands out for its exceptional purity (≥99.5%) and low endotoxin levels, making it the ideal candidate for high-end sustained-release microspheres and implants. With a robust DMF filing and GMP compliance, we empower your drug development process from pilot studies to global commercial launch, ensuring the highest stability and therapeutic efficacy.
Packing & Shipping
Customer Feedback
CONTACT PAGE
1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106
Online instant messaging
2.Contact Information：
Name：Alice
Telephone :+8618509260106
Email:alice@xaheshun.com
FAQ
Q: Can we offer Related products of Goserelin API?
A: Yes, We can provide other peptides,welcome to consult.
Q: What is the purity standard of your Goserelin API ?
A:We provide Goserelin Acetate with a purity of ≥99.0% as determined by HPLC. Our product strictly adheres to USP and EP standards, ensuring that single impurities are controlled below 0.5%. A detailed Certificate of Analysis (CoA) is provided with every batch to guarantee consistent quality for your formulation needs.
Q:What is the typical lead time for bulk orders of Goserelin API?
A:For standard R&D quantities (gram-level), we maintain a ready stock of Goserelin API for immediate dispatch. For commercial-scale bulk orders (kilogram-level), the typical lead time is 4-6 weeks, depending on our current production schedule and your specific quality requirements.
Q:Is a sample of Goserelin API available for pre-clinical lab testing?
A:Yes, we offer high-quality samples of Goserelin API for laboratory evaluation and pre-clinical trials. This allows your R&D team to verify the purity and compatibility of our API before proceeding to large-scale procurement. Please contact our sales team to request a sample pack and technical data sheet.
Q:How do you control the impurity profile, specifically D-isomer levels, in Goserelin API?
A:: Quality control is our priority. During the synthesis of Goserelin API we use advanced Solid-Phase Peptide Synthesis (SPPS) and rigorous purification steps to minimize racemization. We specifically monitor D-isomer and other related substances to ensure they remain well within the stringent limits required for injectable grade peptides.
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