| Product Name | Polyquaternium‑1 |
| Synonym | Polidronium Chloride, PQ‑1, Polyquad, Onamer M |
| CAS No. | 75345‑27‑6 |
| Appearance | Off‑white to amber / light‑brown solid, highly hygroscopic |
| Molecular Formula | C₇H₈N₄O₂ |
| Molecular Weight | 180.16 g/mol |
| Purity | ≥98% HPLC |
| Package | Cold‑pack / ice‑pack transportation, light‑proof required |
| Storage | Sealed, cool and dry place, ‑20 °C recommended for long‑term storage |
| Shelf-Life | 24Months |
Products Description
What Is Polyquaternium‑1?
Polyquaternium‑1, also known as PQ‑1 or Polidronium Chloride (CAS:75345‑27‑6), is a cationic polymeric quaternary ammonium compound. It appears as amber‑brown highly hygroscopic solid material. As an antimicrobial polymeric preservative, it interacts with microbial cell membranes via polycationic properties. It is widely used for ophthalmic formulation R&D, contact‑lens care solution research and cosmetic preservative screening. For Research Use Only. Not for direct human application without complete regulatory validation.
Below are other common polyquaternium cationic polymer analogs besides Polyquaternium‑1. They are widely applied in ophthalmic preservative research, cosmetic conditioning, film‑forming and anti‑static formulation development. COA, SDS and bulk‑supply service are available for these items.
| Product Name | CAS No | Key Features & Main R&D Application |
| Polyquaternium‑1 (PQ‑1, Polidronium Chloride) | 75345‑27‑6 | Cationic polymeric preservative; ophthalmic & contact‑lens solution formulation research, low‑cell‑toxicity antimicrobial screeningPMC |
| Polyquaternium‑7 | 26062‑79‑3 | DADMAC‑acrylamide copolymer; hair‑care conditioning, anti‑static agent, shampoo & body‑wash formulation R&D |
| Polyquaternium‑10 | 68610‑92‑4 | Cation‑modified hydroxyethyl cellulose; hair conditioning, film‑forming agent for transparent cosmetic formulas |
| Polyquaternium‑11 | 53633‑54‑8 | VP‑DMAEMA copolymer; styling film‑former, anti‑static for hair‑care & styling‑product prototyping |
| Polyquaternium‑22 | 53694‑17‑0 | DADMAC‑acrylic acid amphoteric polymer; wide‑pH‑range conditioner for hair‑dye & relaxer formula research |
| Polyquaternium‑16 | 95144‑24‑4 | Vinylpyrrolidone‑vinylimidazole quaternary copolymer; hair‑fixing, antistatic for cosmetic R&D |
| Polyquaternium‑37 | 26161‑33‑1 | Cross‑linked cationic acrylic polymer; thickener & conditioning agent for skin‑care & hair‑care systems |
Applications of Polyquaternium‑1
1.Ophthalmic Formulation R&D Preservative screening for contact‑lens multipurpose solution prototypes, artificial tear formula research, multi‑dose eye‑drop formulation development; evaluated as alternative to benzalkonium chloride (BAK) for reduced ocular‑irritation profile.
2.In‑vitro Antimicrobial & Biocide Research Laboratory testing for bacteriostatic / fungicidal performance, cytotoxicity assessment against corneal epithelial cells, preservative‑effectiveness method validation for pharmaceutical excipient projects.
3.Pharmaceutical Excipient Compatibility Study Compatibility testing with buffers, surfactants and other ophthalmic excipients; stability evaluation of multi‑component aqueous ophthalmic systems.
4.Cosmetic Preservative Screening R&D screening for low‑irritation aqueous cosmetic formulas; limited real‑world cosmetic adoption, mainly focused on ophthalmic‑adjacent cosmetic‑raw‑material evaluation.
Benefits Of Polyquaternium‑1
1.Enables low‑irritation preservative‑system prototyping Offers a viable polymeric alternative to BAK; helps formulators develop multi‑dose ophthalmic prototypes with reduced in‑vitro cytotoxic risk for ocular‑cell‑based screening.
2.Stable antimicrobial performance within ophthalmic pH window Retains preservative efficacy across common formulation pH, reduces extra adjustment work for aqueous ophthalmic systems.
3.Friendly compatibility with mainstream ophthalmic excipients Good compatibility with typical buffers and solubilizers, cuts workload for compatibility‑validation experiments.
4.Valuable property for contact‑lens care solution R&D Exhibits mild substantivity on lens‑material surfaces, supporting development of multi‑purpose lens‑care formula prototypes.
5.Consistent batch quality reduces R&D uncertainty Low‑impurity, well‑characterized raw material minimizes batch‑driven experimental variation, speeds‑up your formulation iteration.
6.Broad reference basis for preservative‑comparison studies Well‑documented reference compound, convenient for side‑by‑side benchmarking against other quaternary‑type preservatives in your lab projects.
Polyquaternium-1 vs Traditional Preservatives (BAK) Comparison
In ophthalmic and multi-dose aqueous formulation research, Benzalkonium Chloride (BAK) has long been the mainstream preservative benchmark. Polyquaternium-1 (PQ-1) is widely studied as a low-irritation polymeric alternative. The following comparison shows core differences in molecular characteristics, safety profile, and formulation applicability to support R&D screening.
|
Item |
Polyquaternium-1 (PQ-1) |
Benzalkonium Chloride (BAK) |
|
Molecular Type |
High-molecular polymeric quaternary ammonium |
Small-molecule quaternary ammonium salt |
|
Ocular Cytotoxicity (In-vitro) |
Low cytotoxicity; rarely penetrates corneal cell membranes |
Higher cytotoxic risk; easy cell penetration at conventional doses |
|
Irritation Profile |
Mild irritation profile, suitable for sensitive ocular formula R&D |
Potential ocular irritation with long-term repeated exposure |
|
Antimicrobial Mechanism |
Surface adsorption & membrane disruption (bacteriostatic) |
Deep cell penetration & rapid bactericidal effect |
|
Compatibility |
Incompatible with anionic surfactants and anionic polymers |
Compatible with most common excipients |
|
Application Focus |
Contact lens solutions, multi-dose eye drops, low-irritation ophthalmic prototypes |
General eye drops, cosmetic and industrial antiseptic formulas |
|
Residual Stimulation Risk |
Low residual stimulation after lens rinsing |
Easy residue accumulation on lens surface |
|
Formula Upgrade Value |
Ideal for next-generation safe ophthalmic formulation iteration |
Cost-effective but limited in high-standard sensitive formulas |
Packaging & Shipping
Packaging feature: Nitrogen‑purged vacuum aluminium foil inner bag with desiccant against moisture absorption (critical for this hygroscopic material)
Sample sizes: 100 mg / 1 g / 5 g, packed in carton.
Bulk sizes: Custom nitrogen‑sealed bulk packaging; custom packing available on request.
Shipping condition: Standard room‑temperature delivery; cold‑chain shipment optional upon request.
Lead time: In‑stock goods ship within 1‑3 working days after order confirmation.
Transport modes: International express for samples; air freight / sea freight for bulk orders.
Documents supplied: COA, SDS‑MSDS, Packing List, Commercial Invoice.
Custom note: Recipient undertakes responsibility for local import tax, duty and regulatory requirements.
Customer Feedback
CONTACT PAGE
If you are searching for a reliable supplier of Polyquaternium‑1 (PQ‑1, Polidronium Chloride, CAS 75345‑27‑6), we offer various pack sizes from small lab samples to bulk raw‑material orders. Special nitrogen‑flushed anti‑moisture packaging is adopted for this highly hygroscopic material. COA, SDS‑MSDS and customs‑related documents can be provided. Kindly send your inquiry to my inforation, our technical‑sales team will respond promptly.
1.Inquiry methods：
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FAQ
Q: What are its solubility characteristics?
A: Slightly soluble in water and DMSO; sparingly soluble in heated methanol; practically insoluble in ethanol and acetone.
Q:What storage conditions should I follow?
A: Keep tightly sealed and avoid moisture. Short‑term storage at 2‑8 °C; long‑term storage recommended at ‑20 °C. Unopened shelf‑life is 2 years.
Q: What technical documents can you provide?
A:COA, SDS‑MSDS are available. HPLC test report can be supplied on customer request.
Q: Is Polyquaternium‑1 compatible with anionic excipients?
A: No. It is incompatible with anionic polymers and anionic surfactants, which will cause precipitation and loss of preservative performance. Compatibility testing is strongly advised for every formula.
Q: What storage conditions should I follow?
A: Keep tightly sealed and avoid moisture. Short‑term storage at 2‑8 °C; long‑term storage recommended at ‑20 °C. Unopened shelf‑life is 2 years.
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