| Product Name | Polydeoxyribonucleotide (PDRN) |
| CAS | 100403-24-5 |
| EINECS | 309-566-6 |
| Apperance | white powder |
| MOQ | 10g, please consult for details |
| Sample And Customize | Support |
| Delivery Time | 7-15 days |
| Shipping Time | sea freight,land transport,air transport,express delivery |
| Package | standard packaging |
| Payment Method | ALL |
| Place of Origin | Shandong China |
| Brand | DeShang |
| Production Capacity | 1000 tons/year |
Quality |
Top Quality |
Products Description
What is Polydeoxyribonucleotide (PDRN) Powder?
Polydeoxyribonucleotide (PDRN) is a low‑molecular‑weight linear DNA fragment, mostly extracted from salmon/trout sperm cells (molecular weight: 50–1500 kDa). Its DNA sequence is ~98% homologous to human DNA, ensuring excellent biocompatibility. It acts mainly via adenosine A2A receptor activation and the nucleotide salvage pathway to drive repair, anti‑inflammation, and regeneration.
Product COA
Certificate Of Analysis
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Product Name |
Polydeoxyribonucleotide (PDRN) Powder |
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Chemical Formula |
N/A |
Molecular Weight |
N/A | |
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CAS |
100403-24-5 |
Batch Quantity |
400kg |
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Batch No. |
MLP-PPH-20231114 |
Manufacture Date |
2025.11.14 |
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Report Date |
2025.11.17 |
Retest Date |
2027.11.13 |
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Testing Items |
Specifications | Test Results | |
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BP2010 /EP6 |
Appearance |
crystalline powder |
Conforms |
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Melting point |
About 205°C |
206.4°C~206.7°C |
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Identification |
Meet the requirements |
Conforms |
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Appearance of solution |
Clear, not more intense than Y7 |
Conforms |
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PH |
2.4~3.0 |
2.60 |
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Loss on drying |
≤0.5% |
0.04% |
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Sulphated ash |
≤0.1% |
0.01% |
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Heavy metals |
≤20 ppm |
<20 ppm |
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Related substances |
≤0.25% |
Conforms |
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Assay |
99.0%~101.0% |
99.8% |
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USP32 |
Identification |
Meet the requirements |
Conforms |
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Loss on drying |
≤0.5% |
0.04% |
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Residue on ignition |
≤0.1% |
0.01% |
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Heavy metals |
≤0.003% |
<0.003% |
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Residue solvent - Ethanol |
≤0.5% |
<0.04% |
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Chloride |
16.9%~17.6% |
17.1% |
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Assay |
98.0%~102.0% |
100.0% |
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Conclusion: The product complies with BP2010/USP32/EP6 standard |
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Key Effects of Polydeoxyribonucleotide (PDRN) Powder
Potent Skin Barrier RepairBoosts synthesis of ceramides and keratins, reduces transepidermal water loss (TEWL), and soothes redness/stinging. Ideal for sensitive skin, rosacea, and post‑procedure recovery (e.g., acid peels, laser treatments).
Collagen Regeneration & Anti‑AgingStimulates fibroblast proliferation, accelerates type I/III collagen synthesis, and inhibits collagenase. Improves fine lines, pores, and elasticity; clinical data show >60% fine‑line improvement after 3–4 regular sessions.
Anti‑Inflammatory & Post‑Acne BrighteningSuppresses pro‑inflammatory factors (TNF‑α, IL‑6) and increases anti‑inflammatory IL‑10. Reduces acne redness, post‑inflammatory hyperpigmentation (PIH), and chronic skin inflammation.
Antioxidant & BrighteningInhibits tyrosinase and MITF, reducing melanin production. Evens skin tone, fades dark spots, and dullness.
Angiogenesis & Microcirculation ImprovementUpregulates VEGF, enhances blood flow, delivers oxygen/nutrients to tissues, and speeds wound healing.
Tissue & Follicle RepairInhibits excessive scarring, accelerates chronic wound healing, and aids hair follicle recovery (adjunctive for androgenetic alopecia).
Applications of Polydeoxyribonucleotide (PDRN) Powder
Medical Aesthetics & Dermatology
Post‑laser/peel repair, sensitive skin care, rosacea management.
Anti‑aging injections/topicals (e.g., salmon DNA mesotherapy), fine lines, pores, sagging.
Acne, PIH, melasma, and dullness treatment.
Scar revision and chronic wound healing (diabetic foot ulcers, pressure sores).
Hair RestorationAdjunct with laser/PRP for androgenetic alopecia; improves follicle vitality and hair density.
Pharmaceuticals & Regenerative Medicine
Orthopedics: plantar fasciitis, lateral epicondylitis, bone/ cartilage repair.
Dentistry: bone grafts, peri‑implantitis, temporomandibular joint disorders.
Chronic inflammation and tissue injury management.
Cosmetics & SkincareAdded to serums, creams, masks, and toners for barrier repair, anti‑aging, brightening, and soothing.
Safety ProfileWell‑tolerated, non‑toxic to major organs (brain, liver, lung, muscle, heart); minimal adverse reactions.
4. Mechanism Summary
A2A receptor activation: anti‑inflammation, angiogenesis, cell protection.
Nucleotide salvage pathway: provides ready‑to‑use DNA building blocks for damaged cells, bypassing de novo synthesis for faster repair.
Important Notes
Dosage & Safety: Flmodafinil is intended for short-term use. Typical doses range from 50-200mg daily. Side effects may include insomnia, headaches, or increased heart rate at higher doses.
Legal Status: It is not approved for medical use in most countries and is primarily available for research purposes.
Storage: Should be stored in a cool, dry, dark place with a shelf life of up to 24 months when properly preserved.
pharmacological differences between flmodafinil and modafinil
⚗️ Chemical Structural Differences
Flmodafinil is a difluoro derivative of Modafinil, with two fluorine atoms added to the para-position of the diphenylmethyl group in its molecular structure. This modification fundamentally alters the pharmacological properties of the drug:
Modafinil: Molecular formula C₁₅H₁₅NO₂S, molecular weight 273.35
Flmodafinil: Molecular formula C₁₅H₁₃F₂NO₂S, molecular weight 309.33
The high electronegativity of fluorine atoms enhances the binding affinity between the molecule and its target, while improving blood-brain barrier penetration efficiency
🎯 Mechanism of Action Differences
Both compounds increase synaptic dopamine levels by inhibiting the dopamine transporter (DAT), but differ in potency and selectivity:
Binding Affinity:
Flmodafinil has 3-4 times higher affinity for DAT than Modafinil (Ki values of 1.4μM vs 4.5μM respectively)
It shows weaker inhibition of norepinephrine transporter (NET) and serotonin transporter (SERT), reducing cardiovascular side effects
Pathway Specificity:
Modafinil also activates the orexin system and glutamatergic neurons
Flmodafinil acts almost exclusively through the dopamine pathway, with a more precise mechanism of action
📊 Pharmacokinetic Differences
| Parameter | Modafinil | Flmodafinil |
|---|---|---|
| Bioavailability | ~60% (with first-pass metabolism) | ~90% (minimal first-pass metabolism) |
| Time to Peak Plasma Concentration | 2-4 hours | 1-2 hours |
| Half-Life | 10-15 hours | 15-20 hours |
| Metabolic Pathway | Primarily metabolized by CYP3A4 | Primarily metabolized by CYP2C19 |
| Active Metabolite | Modafinil acid (inactive) | Fluoromodafinil acid (weakly active) |
💊 Pharmacodynamic Differences
Potency and Dosage:
Flmodafinil is 2-3 times more potent than Modafinil, with an effective dose range of 50-150mg/day
The conventional therapeutic dose of Modafinil is 200-400mg/day
Duration of Action:
Flmodafinil maintains wakefulness for 12-16 hours
Modafinil's effects last approximately 8-12 hours
Cognitive Enhancement:
Flmodafinil shows superior performance in tests of attention, working memory, and reaction speed
Modafinil provides more balanced mood improvement and anti-fatigue effects
⚠️ Safety and Tolerability Differences
Common Side Effects:
Modafinil: Headache, nausea, insomnia (incidence ~10-15%)
Flmodafinil: Headache, anxiety, insomnia (slightly higher incidence ~15-20%)
Drug Interactions:
Modafinil may induce CYP3A4, affecting metabolism of other drugs
Flmodafinil has minimal impact on CYP enzymes, resulting in lower risk of drug interactions
Abuse Potential:
Flmodafinil's stronger dopamine-releasing effect theoretically gives it slightly higher abuse potential than Modafinil
Neither compound is currently classified as a controlled substance, but rational use is advised
📈 Clinical Application Differences
Sleep Disorder Treatment:
Modafinil is FDA-approved for the treatment of narcolepsy, sleep apnea, and shift work sleep disorder
Flmodafinil is currently in clinical research stages and has not received approval for medical use
Cognitive Enhancement:
Flmodafinil demonstrates more significant cognitive improvement in healthy individuals, often used for academic and workplace performance enhancement
Modafinil is more commonly used for medical wakefulness maintenance
Neuropsychiatric Disorders:
Modafinil has been studied as an adjunct therapy for depression, ADHD, and Parkinson's disease
Research on Flmodafinil focuses primarily on cognitive impairment and neuroprotection
Other Nootropics Raw Material Also Available
| Tianeptine sodium salt | 99% | 30123-17-2 |
| Tianeptine Acid | 99% | 66981-73-5 |
| Noopept | 99% | 157115-85-0 |
| Alpha-gpc | 99%/50% | 28319-77-9 |
| 5-HTP | 99% | 56-69-9 |
| CDP-Choline | 99% | 987-78-0 |
| Oxiracetam | 99% | 62613-82-5 |
| NSI-189 | 99% | 1270138-40-3 |
| Sunifiram | 99% | 314728-85-3 |
| Unifiram | 99% | 272786-64-8 |
| Pramiracetam | 99% | 68479-62-1 |
| Piracetam | 99% | 7491-74-9 |
| Agomelatin | 99% | 138112-76-2 |
Packaging & Shipping
Delivery Time:Around 3-5 workdays after your payment.
Package:1kg/aluminium foil bag;25Kgs in fiber-drums with two-plastic bags inside
Net Weight:25kgs/Drum/Gross Weight:28kgs/Drum
Drum Size & Volume:I.D.42cm × H52cm,0.08 m³/Drum
Storage:Stored in dry and cool place,keep away from strong light and heat.
Shelf Life:Two years when properly stored.
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Package |
1kg/bag ,25kg/bag;25kg/drum; customize as customer's equirements. |
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Transit |
Fedex, TNT,DHL,EMS,and so on. |
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Shipping port |
Shanghai/Tianjin/Dalian/Beijing/Xi'an |
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Lead Time |
1-2 working days upon received the payment |
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For mass orders, it will be delivered by air or sea. |
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FAQ
Q: 1. I want to know more details about the product, how can I contact you?
A: You can send us an email inquiry at any time. For more accurate quotes, I need the following information: product name, order quantity, receipt country, quality requirements, etc.
Q: 2. How do I know if your products are real or fake?
A: We will inspect every shipment. I can provide test reports including HPLC, MS and HNMR if you want. Please find a professional chemist to help you confirm the authenticity of the test report.
Of course, you can also purchase samples to take you around your trust.
Q: 3. How do you ensure the safety of the package I receive?
A: I want to receive the package safely, I first need to know your delivery address, do you have a preferred courier method, did you buy it from China?
Why do you want to know?
Because each country has different requirements for imported packages, especially chemical products, you need to know the basic information to provide you with the safest choice.
At present, we have professional customs clearance agents in EU countries, the United States, the United States, Canada, and Southeast Asia. We have professional customs clearance agents to ensure the safety of packages.
Q: 4. How to pay?
A: Our payment channels include bittoin, bank card, Western Union, Allegitudes, etc.
It is usually recommended that customers pay with Bitcoin, because the fee is low, the entry speed is fast, and the security is guaranteed.
Q: 5. How long does it take to receive the package?
A: This will vary according to the delivery method you choose. I will briefly introduce our commonly used special lines.
Usually European countries 10-15 days after sending you the tracking number.
In the United States and Canada, it usually takes 7-10 days.
Southeast Asian countries are 3-7 days.
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