What is acetyl tetrapeptide 3 used for?

Acetyl Tetrapeptide-3 is considered to be a moisturizer or hygroscopic agent, which can help reduce eye edema, improve skin elasticity and overall smoothness. It uses the hygroscopicity of this compound to absorb moisture deep in the skin. The outermost layer of the skin (the stratum corneum), which reduces edema. Its moisturizing function makes it effective for treating dry skin (abnormal dry skin).

Commonly known as: Acetyl Tetrapeptide-3, Acetyl-KGHK peptide.

I.N.C.I. list name: Acetyl Tetrapeptide-3.

Extraction process: Acetylation reaction of tetrapeptide-3.

Source: Synthetic.

Botanical name: /

Family: /

Part of the plant extracted: /

Provenance, origin: china.

Chemical characteristics: A peptide of 4 amino acids (Ac-Lys-Gly-His-Lys-NH2); Molecular weight: 509.6 g/mol; Optimal pH: 4.0 - 8.0; Soluble in DMSO.

Characteristics: Aqueous true solution, emulsion.

Dosage required in cosmetic products: Recommended dosage for preventive care: between 0.5 and 2.5%; Recommended dosage for intensive treatments: between 2.5 and 5%.

Function: Skin protective agent.

Properties: Anti-inflammatory, hair strengthening, hair densifying, hair regenerating.

Benefits: Recommended for preventing and combating the process of hair loss.

1.This ingredient is most often found in eye creams it is also found in shampoo, conditioner, frizz serums, lotions, creams, lip treatments, cleansers, after-sun lotion, soap and body lotions.

2.Acetyl Tetrapeptide-3 has clinically proven anti-edema (reduces fluid build-up) properties and also improves the circulation in the under eye area, reduces puffy eyebags. When applied topically, this ingredient helps prevent and visibly reduces puffiness.

Acetyl Tetrapeptide-3 is the product obtained by the acetylation of Tetrapeptide-3. It's most often found in eye creams. Acetyl tetrapeptisde-5 is a known humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity and overall smoothness.

3.Acetyl tetrapeptide-3 has been shown to reduce puffiness and swelling by changing the micro-circulation in the skin in this area, making it less permeable to fluid,regular use of 0.001% E-yeseryl can reduce the leaking of interstitial fluid into the eye by up to 50% - meaning your eyes have far less swelling and puffing.

4.Science has proven that peptides can help manage wrinkles in your skin and reverse the signs of aging. Human skin is comprised mostly of collagen. Collagen is a protein comprised of long segments of amino acids arranged like a chain. Collagen provides a foundation and thickness for skin. Women under 30 have ample collagen, which results in smooth, tight skin. The rest of us have less collagen - skin tends to be thinner, revealing more wrinkles. When collagen breaks down, short segments of amino acids are formed. These are the tiny proteins and active molecules known as peptides. Peptides in skin care can provide significant anti-aging benefits.

Signal transduction: As an extracellular matrix signal peptide, it activates the ERK/MAPK pathway through Integrin receptors, triggering collagen synthesis.

Gene regulation: Up-regulate genes related to barrier repair (such as FLG, LOR), and enhance epidermal differentiation function.
Anti-glycation: Inhibits the formation of AGEs (Advanced glycation end products) and alleviates the dullness of the skin caused by glycation.

Suitable skin types: dry skin, sensitive skin, early aging skin, and post-medical art repair.
Optimal concentration: 0.01%-0.1% (common addition amount in skin care products).
Synergistic components:
Ceramide: Enhances barrier repair effect.
Hyaluronic acid: Enhances Moisturizing synergy.
Vitamin C/E: Strengthens the antioxidant network.
Avoid pairing: High-concentration acids (such as acids, salicylic acid) may weaken its stability.

A study on patients with dry eczema showed that after using a cream containing 0.05% acetyl tetrapeptidy-3 for 4 weeks, skin moisture loss decreased by 32% and the integrity of the stratum corneum improved (Journal of Cosmetic Dermatology, 2020).

In a double-blind controlled trial, when 0.1% acetyltetrapeptide-3 was used in combination with vitamin C for 8 weeks, the depth of crow's feet decreased by 18% and skin elasticity increased by 23% (Clinical, Cosmetic and Investigational Dermatology, 2021).

In vitro experiments have shown that this component can reduce the release of inflammatory factors induced by LPS by up to 45% (International Journal of Molecular Sciences, 2019).