Buspirone Hydrochloride API CAS 33386-08-2

Buspirone Hydrochloride (Buspirone HCl) is a non-benzodiazepine anxiolytic active pharmaceutical ingredient (API), CAS 33386-08-2. It acts as a partial agonist of the 5‑HT1A serotonin receptor, widely used for generalized anxiety disorder formulation and CNS pharmacology research. Unlike benzodiazepines, it has no obvious sedative, muscle relaxant or anticonvulsant effects, with low dependence risk. We supply buspirone hydrochloride powder complying with USP / EP / Chinese Pharmacopoeia standard, full test documents including COA, HPLC, SDS available for bulk buyers, pharmaceutical factories and CRO labs.

1. Formulation development for generalized anxiety disorder oral tablets

Buspirone Hydrochloride API is mainly applied in the R&D and production of oral immediate-release tablets targeting generalized anxiety disorder (GAD). It serves as the core active ingredient for prescription solid oral dosage forms. Formulation teams test powder blending, granulation, compression and dissolution profiles to meet pharmacopoeia standards such as USP and EP. It is an alternative anxiolytic raw material without benzodiazepine-related sedative and dependence risks.

2.Capsule dosage form research and feasibility study

This API is used for feasibility trials and lab-scale development of hard gelatin capsules. R&D institutes and CROs evaluate powder flowability, compatibility with excipients (lactose, microcrystalline cellulose, croscarmellose sodium), content uniformity and stability under accelerated stability conditions. Capsule formulations are developed for customized dosing requirements in clinical trial batches.

3.Pharmacology & preclinical research for 5-HT1A receptor mechanism study

Widely supplied to university labs, research institutions and CROs for preclinical pharmacological studies. Researchers use Buspirone Hydrochloride as a reference compound to investigate serotonin 1A receptor signaling pathways, central nervous system (CNS) modulation, anxiolytic mechanism, and to compare pharmacological profiles with other azapirone class compounds such as tandospirone and gepirone.

4.Pharmacopoeia reference & analytical method validation

Qualified Buspirone Hydrochloride powder can be adopted as working reference substance for pharmaceutical QC laboratories. It supports HPLC method validation, system suitability test, impurity profiling, limit of quantitation (LOQ) and limit of detection (LOD) verification. QC labs establish and verify in-house testing procedures aligned with USP monograph requirements for incoming raw material inspection.

5.Generic drug registration batch manufacturing & DMF supporting supply

For generic drug manufacturers, bulk Buspirone Hydrochloride API is supplied for registration stability batches and bioequivalence (BE) study batches. Suppliers provide full documentation packages including COA, TDS, SDS, impurity data and stability data to support ANDA or local generic registration submission in different regions. Flexible batch sizes cover small registration batches and later commercial scale-up.

1.High purity Buspirone Hydrochloride raw material, stable batch-to-batch consistency, easy for finished pharmaceutical formulation.

2.Strict impurity control in line with USP/EP reference standards, supports regulatory documentation submission.

3.Good solubility and processability, suitable for tablet and capsule production.

4.Reliable supply chain with flexible MOQ options to meet R&D trial and commercial bulk orders.

5.Complete supporting documents available: COA, TDS, SDS, residual solvent & heavy metal test reports for your registration.

Packing: Aluminium foil bag / aluminium can / 25kg fiber drum, double sealed for moisture proof and light shielding

Shipping: International express for small lab samples; sea / air freight for bulk API. We provide shipping document support.

If you want to purchase high purity Buspirone Hydrochloride (Buspirone HCl)  please contact our sales team directly. We supply lab samples and large bulk quantity, every batch comes with COA and SDS. Send your required quantity and purity grade via email, our specialist will provide quotation, lead time and shipping details quickly.

1.Inquiry methods：
Email:alice@xaheshun.com
Whatspp:+8618509260106

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2.Contact Information：
Name：Alice

Telephone :+8618509260106
Email:alice@xaheshun.com

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